Results 221 to 230 of about 205,945 (302)

The gut microbiome and drug‐resistant epilepsy: Microbiome–antiseizure medication interactions and implications for pharmacoresistance

Epilepsia Open, EarlyView.
Abstract Drug‐resistant epilepsy (DRE) affects approximately one‐third of patients with epilepsy and represents a major unmet clinical need. While traditional hypotheses of pharmacoresistance have focused on alterations in drug targets, efflux transporter overexpression, and intrinsic disease severity, the gut microbiome has recently emerged as a ...
Khaled Zammar, Majd A. AbuAlrob, Musab Ali, Simona Lattanzi, Boulenouar Mesraoua   +4 more
wiley   +1 more source

Sleep and stress as modifiable drivers of Alzheimer's disease. [PDF]

NPJ Dement
Wear D, Hussaini SA, Yu WH.
europepmc   +1 more source

Structural morphometry distinguishes vagus nerve stimulation outcomes in individuals with epilepsy

Epilepsia Open, EarlyView.
Abstract Objective Vagus nerve stimulation (VNS) is a commonly used treatment for drug‐resistant epilepsy. However, response to VNS is variable, while understanding of this response variability is limited. The vagus afferent network (VagAN), the neural circuits thought to be involved in response to vagal afferents, has been implicated in response ...
Harry J. Clifford, Sonja Fenske, Yujiang Wang, Tiago da Silva Costa, Rhys H. Thomas, Sabahat Iqbal, Cameron A. Elliott, Davide Giampiccolo, John S. Duncan, Peter N. Taylor   +9 more
wiley   +1 more source

Whole-Transcriptome Sequencing and ceRNA Network Analysis of the Hypothalamus During the Follicular Phase in High- and Low-Fecundity Xinjiang Goats. [PDF]

Int J Mol Sci
Wu Y, Dong W, Xing W, Saimaiti S, Xu Y, Zhang M, Lv X, Zheng W.   +7 more
europepmc   +1 more source

Efficacy and safety of fenfluramine in Dravet syndrome: The impact of patient clinical characteristics

Epilepsia Open, EarlyView.
This graphical abstract provides an overview of the content from this post hoc analysis evaluating the efficacy and safety of fenfluramine in patients with Dravet syndrome stratified by age, number of previously attempted antiseizure medications, and SCN1A pathogenic variant status using data pooled from the three pivotal randomized controlled trials ...
Rima Nabbout, Joseph Sullivan, Stéphane Auvin, J. Helen Cross, Orrin Devinsky, Antonio Gil‐Nagel, Renzo Guerrini, Kelly G. Knupp, M. Scott Perry, Rocío Sánchez‐Carpintero, An‐Sofie Schoonjans, Ingrid E. Scheffer, Nicola Specchio, Adam Strzelczyk, James Wheless, Elaine C. Wirrell, Diego Morita, Patrick Healy, Mélanie Langlois, Amélie Lothe, Lieven Lagae   +20 more
wiley   +1 more source

Amylin: A Multi-Functional Pancreatic Hormone-A Review. [PDF]

Diabetes Obes Metab
Le Foll C, Lutz TA.
europepmc   +1 more source

Rare genetic variation in adults with surgically treated temporal lobe epilepsy: An exome sequencing study

Epilepsia Open, EarlyView.
Abstract Objective To determine the frequency of monogenic variants and pathogenic copy number variants (CNVs) in adults with surgically treated temporal lobe epilepsy (TLE). Methods We performed exome sequencing (ES), including CNV analysis, in 45 adults with TLE who had previously undergone epilepsy surgery.
Antonia P. Pirker, Margot Ernst, Matias Wagner, Silvia B. Bonelli, Karin Trimmel, Judith Jud, Elisabeth Graf, Christian Dorfer, Karl Rössler, Susanne Aull‐Watschinger, Ekaterina Pataraia, Fritz Zimprich, Martin Krenn   +12 more
wiley   +1 more source

Identification of candidate genes and ceRNA networks of HPG axis in regulating sexual precocity of roosters by whole transcriptomic sequencing. [PDF]

BMC Genomics
Xiang H, Li X, Sun X, Zhang Z, Wei J, Liu Z, Ma Z, Chen S, Gou J, Ye F, Li H.   +10 more
europepmc   +1 more source

Resumption of Menses and Normalisation of Body Weight in Adolescents Undergoing Specialised Treatment for Anorexia Nervosa Inpatient or Outpatient Treatment

European Eating Disorders Review, EarlyView.
ABSTRACT Objective To predict resumption of menses (ROM) in patients with anorexia nervosa (AN). Method Females aged 9–17 years with AN, receiving inpatient multimodal treatment (IMT) or family‐based treatment (FBT) underwent assessments at baseline, 6‐month and 12‐month follow‐up (12FU).
Annika Woltmann, Linus Imken, Vivien Kaiser, Johanna L. Keeler, Daniel Le Grange, Christoph U. Correll, Verena Haas   +6 more
wiley   +1 more source

The transcriptional cortical response to daily torpor in <i>Phodopus sungorus</i>. [PDF]

Life Sci Alliance
Bal LC, Woo MS, Rothammer N, Haugg E, Mayer C, Herwig A, Friese MA.   +6 more
europepmc   +1 more source