Role of hypothalamus function in metabolic diseases and its potential mechanisms [PDF]
PeerJThe hypothalamus, a crucial neuroendocrine regulatory center, plays a significant role in the occurrence and development of metabolic diseases. Recent advances in molecular biology and imaging technology have facilitated a better understanding of the ...
Xinyu Zhang +4 more
doaj +2 more sources
Exogenous spermidine affects polyamine metabolism in the mouse hypothalamus
Open Life Sciences, 2021 Spermidine is important for the hypothalamic control of pituitary secretion of hormones involved in neuroendocrine functions in mammals. In this study, the effect of exogenous spermidine on the expression of genes and proteins related to polyamine ...
Jiang Dongmei +3 more
doaj +1 more source
GABA\u3csub\u3eA\u3c/sub\u3e and excitatory amino acid receptors in dorsomedial hypothalamus and heart rate in rats [PDF]
, 1991 We have previously shown that microinjection of drugs that interfere with the function of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA) into the hypothalamus produces cardiorespiratory and behavioral changes resembling those seen in ...
DiMicco, Joseph A., Soltis, Robert P.
core +2 more sources
Inhibition of Food Intake by PACAP in the Hypothalamic Ventromedial Nuclei is Mediated by NMDA Receptors [PDF]
, 2014 Central injections of pituitary adenylate cyclase-activating polypeptide (PACAP) into the ventromedial nuclei (VMN) of the hypothalamus produce hypophagia that is dependent upon the PAC1 receptor; however, the signaling downstream of this receptor in the
Choi, Sujean +3 more
core +2 more sources
A Molecular Census of Arcuate Hypothalamus and Median Eminence Cell Types
Nature Neuroscience, 2017 The hypothalamic arcuate–median eminence complex (Arc-ME) controls energy balance, fertility and growth through molecularly distinct cell types, many of which remain unknown. To catalog cell types in an unbiased way, we profiled gene expression in 20,921
John N. Campbell +12 more
semanticscholar +1 more source
Cellular and molecular properties of neural progenitors in the developing mammalian hypothalamus
Nature Communications, 2020 The neuroendocrine hypothalamus is the central regulator of vital physiological homeostasis and behavior. However, the cellular and molecular properties of hypothalamic neural progenitors remain unexplored.
Xin Zhou +10 more
semanticscholar +1 more source
Identification of sex hormone-binding globulin in the human hypothalamus [PDF]
, 2005 Gonadal steroids are known to influence hypothalamic functions through both genomic and non-genomic pathways. Sex hormone-binding globulin ( SHBG) may act by a non-genomic mechanism independent of classical steroid receptors.
Becchis M +35 more
core +1 more source
Interaction of hypothalamic GABA\u3csub\u3eA\u3c/sub\u3e and excitatory amino acid receptors controlling heart rate in rats [PDF]
, 1991 We have previously shown that microinjection of drugs that impair gamma-aminobutyric acid (GABA)-mediated synaptic inhibition into the dorsomedial hypothalamus (DMH) of rats generates cardiovascular and behavioral changes that mimic the response to ...
DiMicco, Joseph A., Soltis, Robert P.
core +2 more sources
Distribution and characterisation of Glucagon-like peptide-1 receptor expressing cells in the mouse brain. [PDF]
, 2015 © 2015 The Authors.Objective: Although Glucagon-like peptide 1 is a key regulator of energy metabolism and food intake, the precise location of GLP-1 receptors and the physiological relevance of certain populations is debatable.
Cork, SC +5 more
core +2 more sources
Feeding Stimulates Sphingosine-1-Phosphate Mobilization in Mouse Hypothalamus. [PDF]
, 2019 Previous studies have shown that the sphingolipid-derived mediator sphingosine-1-phosphate (S1P) reduces food intake by activating G protein-coupled S1P receptor-1 (S1PR1) in the hypothalamus.
Misto, Alessandra +3 more
core +1 more source