Results 21 to 30 of about 318,025 (287)

Timing of maternal exposure and fetal sex determine the effects of low-level chemical mixture exposure on the fetal neuroendocrine system in sheep [PDF]

open access: yes, 2016
We have shown that continuous maternal exposure to the complex mixture of environmental chemicals (ECs) found in human biosolids (sewage sludge), disrupts mRNA expression of genes crucial for development and long-term regulation of hypothalamo-pituitary ...
Bellingham, M.   +7 more
core   +2 more sources

Notch signalling and proneural genes work together to control the neural building blocks for the initial scaffold in the hypothalamus

open access: yesFrontiers in Neuroanatomy, 2014
The vertebrate embryonic prosencephalon gives rise to the hypothalamus, which plays essential roles in sensory information processing as well as control of physiological homeostasis and behaviour.
Michelle eWare   +2 more
doaj   +1 more source

Transcriptomics analysis unveils key potential genes associated with brain development and feeding behavior in the hypothalamus of L-citrulline-fed broiler chickens

open access: yesPoultry Science, 2023
: High ambient temperature is a major environmental stressor affecting poultry production, especially in the tropical and subtropical regions of the world. Nutritional interventions have been adopted to combat thermal stress in poultry, including the use
Victoria Anthony Uyanga   +9 more
doaj   +1 more source

Distribution and characterisation of Glucagon-like peptide-1 receptor expressing cells in the mouse brain. [PDF]

open access: yes, 2015
© 2015 The Authors.Objective: Although Glucagon-like peptide 1 is a key regulator of energy metabolism and food intake, the precise location of GLP-1 receptors and the physiological relevance of certain populations is debatable.
Cork, SC   +5 more
core   +2 more sources

Transcriptome analysis of Shank3-overexpressing mice reveals unique molecular changes in the hypothalamus

open access: yesMolecular Brain, 2018
Various mutations in the SH3 and multiple ankyrin repeat domains 3 (SHANK3) gene are associated with neurodevelopmental and neuropsychiatric disorders.
Chunmei Jin   +6 more
doaj   +1 more source

Identification of sex hormone-binding globulin in the human hypothalamus [PDF]

open access: yes, 2005
Gonadal steroids are known to influence hypothalamic functions through both genomic and non-genomic pathways. Sex hormone-binding globulin ( SHBG) may act by a non-genomic mechanism independent of classical steroid receptors.
Becchis M   +35 more
core   +1 more source

Huntingtin-Associated Protein 1 in Mouse Hypothalamus Stabilizes Glucocorticoid Receptor in Stress Response

open access: yesFrontiers in Cellular Neuroscience, 2020
Huntingtin-associated protein 1 (Hap1) was initially identified as a brain-enriched protein that binds to the Huntington’s disease protein, huntingtin. Unlike huntingtin that is ubiquitously expressed in the brain, Hap1 is enriched in the brain with the ...
Xingxing Chen   +13 more
doaj   +1 more source

It takes two to tango: NAD+ and sirtuins in aging/longevity control [PDF]

open access: yes, 2016
The coupling of nicotinamide adenine dinucleotide (NAD+) breakdown and protein deacylation is a unique feature of the family of proteins called ‘sirtuins.’ This intimate connection between NAD+ and sirtuins has an ancient origin and provides a ...
Guarente, Leonard, Imai, Shin-ichiro
core   +2 more sources

Maternal glucose intolerance during pregnancy affects offspring POMC expression and results in adult metabolic alterations in a sex-dependent manner

open access: yesFrontiers in Endocrinology, 2023
IntroductionGestational diabetes (GDM) is associated with negative outcomes in mothers and their offspring, including greater risks of macrosomia at birth and the development of metabolic disorders.
Marina Galleazzo Martins   +8 more
doaj   +1 more source

Hypothalamic Microinflammation: New Paradigm In Obesity And Metabolic Disease

open access: yesIndonesian Biomedical Journal, 2020
BACKGROUND: Hypothalamus is the master regulator of body’s systemic homeostasis including energy balance, body temperature, sleep, blood pressure, and circadian rhythms.
Anna Meiliana   +2 more
doaj   +1 more source

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