Results 21 to 30 of about 245,222 (354)

Novel human pluripotent stem cell-derived hypothalamus organoids demonstrate cellular diversity

iScience, 2023
Summary: The hypothalamus is a region of the brain that plays an important role in regulating body functions and behaviors. There is a growing interest in human pluripotent stem cells (hPSCs) for modeling diseases that affect the hypothalamus.
Lily Sarrafha, Drew R. Neavin, Gustavo M. Parfitt, Ilya A. Kruglikov, Kristen Whitney, Ricardo Reyes, Elena Coccia, Tatyana Kareva, Camille Goldman, Regine Tipon, Gist Croft, John F. Crary, Joseph E. Powell, Joel Blanchard, Tim Ahfeldt   +14 more
doaj  

Notch signalling and proneural genes work together to control the neural building blocks for the initial scaffold in the hypothalamus

Frontiers in Neuroanatomy, 2014
The vertebrate embryonic prosencephalon gives rise to the hypothalamus, which plays essential roles in sensory information processing as well as control of physiological homeostasis and behaviour.
Michelle eWare, Houda eHamdi-Rozé, Valérie eDupé   +2 more
doaj   +1 more source

Complex negative emotions induced by electrical stimulation of the human hypothalamus

Brain Stimulation, 2022
Background: Stimulation of the ventromedial hypothalamic region in animals has been reported to cause attack behavior labeled as sham-rage without offering information about the internal affective state of the animal being stimulated.
Josef Parvizi, Michael J. Veit, Daniel A.N. Barbosa, Aaron Kucyi, Claire Perry, Jonathon J. Parker, Rajat S. Shivacharan, Fengyixuan Chen, Jennifer Yih, James J. Gross, Robert Fisher, Jennifer A. McNab, Jessica Falco-Walter, Casey H. Halpern   +13 more
doaj  

Transcriptome analysis of Shank3-overexpressing mice reveals unique molecular changes in the hypothalamus

Molecular Brain, 2018
Various mutations in the SH3 and multiple ankyrin repeat domains 3 (SHANK3) gene are associated with neurodevelopmental and neuropsychiatric disorders.
Chunmei Jin, Hyojin Kang, Shinhyun Kim, Yinhua Zhang, Yeunkum Lee, Yoonhee Kim, Kihoon Han   +6 more
doaj   +1 more source

A hypothalamus-habenula circuit controls aversion

Molecular Psychiatry, 2019
Encoding and predicting aversive events are critical functions of circuits that support survival and emotional well-being. Maladaptive circuit changes in emotional valence processing can underlie the pathophysiology of affective disorders.
I. Lazaridis, Ourania Tzortzi, M. Weglage, Antje Märtin, Yang Xuan, M. Parent, Yvonne Johansson, J. Fuzik, Daniel Fürth, L. Fenno, C. Ramakrishnan, G. Silberberg, K. Deisseroth, M. Carlén, K. Meletis   +14 more
semanticscholar   +1 more source

Hypothalamic Microinflammation: New Paradigm In Obesity And Metabolic Disease

Indonesian Biomedical Journal, 2020
BACKGROUND: Hypothalamus is the master regulator of body’s systemic homeostasis including energy balance, body temperature, sleep, blood pressure, and circadian rhythms.
Anna Meiliana, Nurrani Mustika Dewi, Andi Wijaya   +2 more
doaj   +1 more source

Vasopressin modulates hypothalamo-pituitary activity by paracrine action during acute and chronic immobilization stress in rats [PDF]

Archives of Biological Sciences, 2011
The aim of the study was to examine changes in corticotropin releasing hormone (CRH), vasopressin (VP), adrenocorticotropin (ACTH) as well as VP3 receptor protein concentration in the hypothalamus and the pituitary of rats exposed to acute (3 h) and ...
Lakić Iva, Vujović P., Jasnić N., Đurašević S., Cvijić Gordana   +4 more
doaj   +1 more source

Esr1+ cells in the ventromedial hypothalamus control female aggression

Nature Neuroscience, 2017
As an essential means of resolving conflicts, aggression is expressed by both sexes but often at a higher level in males than in females. Recent studies suggest that cells in the ventrolateral part of the ventromedial hypothalamus (VMHvl) that express ...
Koichi Hashikawa, Y. Hashikawa, R. Tremblay, Jiaxing Zhang, James E. Feng, Alexander Sabol, Walter T. Piper, Hyosang Lee, B. Rudy, Dayu Lin   +9 more
semanticscholar   +1 more source

Identification of targets of leptin action in rat hypothalamus.

Journal of Clinical Investigation, 1996
The hypothesis that leptin (OB protein) acts in the hypothalamus to reduce food intake and body weight is based primarily on evidence from leptin-deficient, ob/ob mice.
M. Schwartz, R. Seeley, L. Campfield, P. Burn, D. Baskin   +4 more
semanticscholar   +1 more source

An Integrated Event-Driven Real-Time Tactical–Operational Optimization Framework for Smart Port Operations Planning

Logistics
The ongoing issues in global supply chain disruptions have raised many concerns of port productivity, among which port congestion is a key issue.
Danilo Abril, Carlos D. Paternina-Arboleda, Jesus Velasquez-Bermudez   +2 more
doaj   +1 more source