Results 81 to 90 of about 323,717 (308)

Peripheral and central mechanisms involved in hormonal control of male and female reproduction [PDF]

, 2016
Reproduction involves the integration of hormonal signals acting across multiple systems togenerate a synchronized physiological output. A critical component of reproduction is the luteinizinghormone (LH) surge, which is mediated by estradiol (E2) and ...
Bentley, G. E., Calandra, Ricardo Saul, Micevych, P. E., Paredes, A. H., Rudolph, L. M., Tesone, Marta, Wu, T. J.   +6 more
core   +1 more source

Gut Bacteria Improve Depressive Symptoms by Degrading Cortisol into Androgen

Advanced Science, EarlyView.
Chronic stress is an important risk factor for stress‐related disorders such as depression. Stress hormone cortisol is essential for the pathogenesis of stress‐related disorders such as depression. Some gut microbiota degraded cortisol, and improve depressive symptoms.
Xiong Wang, Qing Wu, Hao‐Long Zeng, Yin Shen, Hong‐Han Zhang, Jun Gong, Qi Zhang, Jia‐Zhao Xie, Da‐Wei Ye, Zi‐Yong Sun, Zhong‐Chun Liu, Li‐Ming Cheng, Di Li   +12 more
wiley   +1 more source

Charge Characteristics of Agouti-Related Protein Implicate Potent Involvement of Heparan Sulfate Proteoglycans in Metabolic Function. [PDF]

, 2019
The endogenous melanocortin peptide agouti-related protein (AgRP) plays a well-known role in foraging, but its contribution to metabolic regulation is less understood.
Chen, Jihuan, Chen, Valerie, Hoang, Ivy, Kawamura, Tomoya, McBride, Ryan, Millhauser, Glenn L, Repunte-Canonigo, Vez, Sanna, Pietro Paolo, Wong, Ashley Tess, Yang, Yang   +9 more
core   +1 more source

Early life stress decreases cell proliferation and the number of putative adult neural stem cells in the adult hypothalamus [PDF]

, 2021
Pascal Bielefeld, Maralinde R. Abbink, Anna R. Davidson, Niels Reijner, Oihane Abiega, Paul J. Lucassen, Anikó Kőrösi, Carlos P. Fitzsimons   +7 more
openalex   +1 more source

Taurocholic Acid Is Associated With Disturbed Functional Connectivity in the Hippocampus of Patients With Depression

Advanced Science, EarlyView.
This study identifies elevated taurocholic acid (TCA) in Major Depressive Disorder patients. Gut microbiome‐associated TCA impairs hippocampal neurogenesis, triggers microglia activation, and elicits depression‐like behavior in mice via the S1PR2. In patients, functional neuroimaging reveals that serum TCA levels correlate with altered functional ...
Xiaoying Cai, Taipeng Sun, Mengzhen Feng, Gang Chen, Junchi Zhou, Hong Zhuang, Dan Wang, Ying Chen, Zhen Cheng, Zhi Xu, Xiao Zheng, Xueli Zhang, Yonggui Yuan   +12 more
wiley   +1 more source

Oxytocin is implicated in social memory deficits induced by early sensory deprivation in mice [PDF]

, 2016
Acknowledgements We thank Miss Jia-Yin and Miss Yu-Ling Sun for their help in breading the mice. Funding This work was supported by grants from the National Natural Science Foundation of China (81200933 to N.-N. Song; 81200692 to L.
Chen, Ling, Ding, Yu-Qiang, Huang, Ying, Lang, Bing, Lv, Zhu-Man, Niu, Xue-Yuan, Pruski, Michal, Qi, Cong-Cong, Shao, Can-Can, Song, Ning-Ning, Zhang, Chan, Zhang, Jin-Bao   +11 more
core   +2 more sources

Mechanisms Driving Palmitate-Mediated Neuronal Dysregulation in the Hypothalamus [PDF]

, 2021
Calvin V. Lieu, Neruja Loganathan, Denise D. Belsham   +2 more
openalex   +1 more source

Exclusive Breastfeeding Drives AMPK‐Dependent Thermogenic Memory in BAT and Promotes Long‐Term Metabolic Benefits in Offspring

Advanced Science, EarlyView.
Exclusive breastfeeding establishes a thermogenic memory in brown adipose tissue by activating the HIF1AN/AMPK/α‐ketoglutarate axis via milk‐derived extracellular vesicles enriched in miR‐125a‐5p. This programming preserves metabolic health, while αKG supplementation restores BAT function under mixed feeding, offering strategies to mitigate the ...
Ningxi Wu, Anwen Yin, Xiang Yu, Mingxin Wang, Jiahui Zhang, Kerong Liu, Yutong Hou, Minkai Cao, Yiting Zhang, Xiaoxiao Zhang, Yao Gao, Xirong Guo, Le Zhang, Yun Li   +13 more
wiley   +1 more source

Identification and Characterization of Hypothalamic Alternative Splicing Events and Variants in Ovine Fecundity-Related Genes

Animals, 2020
Previous studies revealed that alternative splicing (AS) events and gene variants played key roles in reproduction; however, their location and distribution in hypothalamic fecundity-related genes in sheep without the FecB mutation remain largely unknown.
Zhuangbiao Zhang, Jishun Tang, Xiaoyun He, Ran Di, Xiaosheng Zhang, Jinlong Zhang, Wenping Hu, Mingxing Chu   +7 more
doaj   +1 more source

Nurr1 Orchestrates Claustrum Development and Functionality

Advanced Science, EarlyView.
Nurr1 (Nr4a2) is the master transcription factor to control claustrum morphogenesis and cell fate decision postmitotically by inhibiting intracellular G‐protein signaling. Nurr1 deficiency alters the transcriptomic profiles of subcortical claustral neurons into neocortical insular neurons, resulting in defected claustrum development, impaired axonal ...
Kuo Yan, Andrew G. Newman, Pauline Lange, Susanne Müller, Marco Foddis, Stefan Paul Koch, Philipp Böhm‐Sturm, Maron Mantwill, Carsten Finke, Penghui Deng, Melissa Long, Dietmar Schmitz, Victor Tarabykin   +12 more
wiley   +1 more source