Involvement of orexin neurons in fasting- and central adenosine-induced hypothermia [PDF]
Scientific Reports, 2018 We examined whether orexin neurons might play a protective role against fasting- and adenosine-induced hypothermia. We first measured body temperature (BT) in orexin neuron-ablated (ORX-AB) mice and wild-type (WT) controls during 24 hours of fasting.
Takahiro Futatsuki +6 more
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Hypothermia Induced Impairment of Platelets: Assessment With Multiplate vs. ROTEM-An In Vitro Study. [PDF]
Front Physiol, 2022 Introduction: This experimental in vitro study aimed to identify and characterize hypothermia-associated coagulopathy and to compare changes in mild to severe hypothermia with the quantitative measurement of rotational thromboelastometry (ROTEM) and ...
Wallner B +7 more
europepmc +2 more sources
Effect of Lonicerae japonicae Flos Carbonisata-Derived Carbon Dots on Rat Models of Fever and Hypothermia Induced by Lipopolysaccharide. [PDF]
Int J Nanomedicine, 2020 Introduction A correlation is established between the efficacy of Chinese herbal medicine and its charcoal drugs. Lonicerae japonicae Flos (LJF) is commonly used to treat fever, carbuncle, and tumors, among others.
Wu J +8 more
europepmc +2 more sources
Hypothermia-Induced Electrocardiographic Changes. [PDF]
Arq Bras Cardiol, 2020 This is an open-access article distributed under the terms of the Creative Commons Attribution License.
Marques A +4 more
europepmc +4 more sources
Integrated transcriptomics and metabolomics confirms the oxidative stress mechanism of hypothermia-induced neuronal necroptosis [PDF]
Cellular & Molecular Biology LettersAbnormal climate change seriously endangers the safety of outdoor work and life, often causing hypothermia-induced coma or death. As the underlying mechanism has not been fully elucidated, a targeted treatment for hypothermia-triggered neuronal injury ...
Song-Jun Wang +7 more
doaj +2 more sources
Treatment of acute carbon monoxide poisoning with induced hypothermia [PDF]
Clinical and Experimental Emergency Medicine, 2016 Objective The effect of induced hypothermia on severe acute carbon monoxide (CO) poisoning remains to be addressed further. We investigated the effect of induced hypothermia on severe acute CO poisoning.
Byoung-Joon Oh +4 more
doaj +2 more sources
Hypothermia-Induced Ubiquitination of Voltage-Dependent Anion Channel 3 Protects BV2 Microglia Cells From Cytotoxicity Following Oxygen-Glucose Deprivation/Recovery [PDF]
Frontiers in Molecular Neuroscience, 2020 Background: Hypothermia attenuates microglial activation and exerts a potential neuroprotective effect against cerebral ischemic-reperfusion (I/R) injury. However, the underlying mechanism remains to be elucidated.
Shen Zhao +12 more
doaj +2 more sources
Induced Hypothermia Does Not Harm Hemodynamics after Polytrauma: A Porcine Model
Mediators of Inflammation, 2015 Background. The deterioration of hemodynamics instantly endangers the patients’ life after polytrauma. As accidental hypothermia frequently occurs in polytrauma, therapeutic hypothermia still displays an ambivalent role as the impact on the ...
Matthias Weuster +10 more
doaj +2 more sources
Phenothiazines Enhance Mild Hypothermia-induced Neuroprotection via PI3K/Akt Regulation in Experimental Stroke. [PDF]
Sci Rep, 2017 Physical hypothermia has long been considered a promising neuroprotective treatment of ischemic stroke, but the treatment’s various complications along with the impractical duration and depth of therapy significantly narrow its clinical scope.
An H +12 more
europepmc +2 more sources
The RNA-binding protein RBM3 is involved in hypothermia induced neuroprotection
Neurobiology of Disease, 2011 Induced hypothermia is the only therapy with proven efficacy to reduce brain damage after perinatal asphyxia. While hypothermia down-regulates global protein synthesis and cell metabolism, low temperature induces a small subset of proteins that includes ...
Sophorn Chip +6 more
doaj +2 more sources