Neuroprotection by Therapeutic Hypothermia
Frontiers in Neuroscience, 2019 Hypothermia therapy is an old and important method of neuroprotection. Until now, many neurological diseases such as stroke, traumatic brain injury, intracranial pressure elevation, subarachnoid hemorrhage, spinal cord injury, hepatic encephalopathy, and
Ying-Jian Sun +3 more
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Effect of Trans-Nasal Evaporative Intra-arrest Cooling on Functional Neurologic Outcome in Out-of-Hospital Cardiac Arrest : The PRINCESS Randomized Clinical Trial [PDF]
, 2019 © 2019 American Medical Association. All rights reserved.Importance: Therapeutic hypothermia may increase survival with good neurologic outcome after cardiac arrest.
Abella +43 more
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Facts and Fiction: The Impact of Hypothermia on Molecular Mechanisms following Major Challenge
Mediators of Inflammation, 2012 Numerous multiple trauma and surgical patients suffer from accidental hypothermia. While induced hypothermia is commonly used in elective cardiac surgery due to its protective effects, accidental hypothermia is associated with increased posttraumatic ...
Michael Frink +4 more
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Comparison between Gel Pad Cooling Device and Water Blanket during Target Temperature Management in Cardiac Arrest Patients [PDF]
Acute and Critical Care, 2018 Background: Target temperature management (TTM) improves neurological outcomes for comatose survivors of out-of-hospital cardiac arrest. We compared the efficacy and safety of a gel pad cooling device (GP) and a water blanket (WB) during TTM. Methods: We
Yoon Sun Jung +3 more
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Moderate hypothermia within 6 h of birth plus inhaled xenon versus moderate hypothermia alone after birth asphyxia (TOBY-Xe): a proof-of-concept, open-label, randomised controlled trial [PDF]
, 2015 Background Moderate cooling after birth asphyxia is associated with substantial reductions in death and disability, but additional therapies might provide further benefit.
Azzopardi, D +17 more
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Effect of hypothermia on haemostasis and bleeding risk: a narrative review
Journal of International Medical Research, 2019 It must be remembered that clinically important haemostasis occurs in vivo and not in a tube, and that variables such as the number of bleeding events and bleeding volume are more robust measures of bleeding risk than the results of analyses.
Thomas Kander, Ulf Schött
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Mechanisms of hypothermia-induced cell protection in the brain
Molecular and Cellular Pediatrics, 2014 Therapeutic hypothermia is an effective cytoprotectant and promising intervention shown to improve outcome in patients following cardiac arrest and neonatal hypoxia-ischemia.
K. Schmitt, G. Tong, F. Berger
semanticscholar +1 more source
Neuroprotective Properties of Xenon. [PDF]
, 2020 Xenon is a rare noble gas that was introduced into clinical practice more than 70 years ago. Xenon's clinical properties are predicated by its ability to fit into preformed cavities of macromolecules thereby altering their biological functions.
Laitio, Timo, Maze, Mervyn
core
Hypothermia-Induced Thrombocytopenia [PDF]
Journal of the Royal Society of Medicine, 1988 M A, Vella +3 more
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PD149163 induces hypothermia to protect against brain injury in acute cerebral ischemic rats
Journal of Pharmacological Sciences, 2017 Therapeutic hypothermia is a promising strategy for acute cerebral ischemia via physical or pharmacological methods. In this study, we pharmacologically induced hypothermia on Sprague Dawley rats by intraperitoneally injecting PD149163.
Teng-Fei Xue +7 more
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