Results 91 to 100 of about 16,203 (292)

Comparison Comparison of Isotonic Versus Hypotonic Fluids in Neonates on Maintenance Fluid Therapy

Introduction:  In neonates, the use of hypotonic fluids is a widely accepted practice to maintain hydration and electrolyte balance, particularly after surgery.
Fatima, Mehak, Gondal, Dr Mudassir Fiaz, Shahwar, Ameena, Ahmed, Waqas, Aslam, Hasnain, Rasool, Laraib   +5 more
core   +1 more source

Membrane Fusion‐Mediated Cytosolic Delivery of Threose Nucleic Acids via Homotypic Nanoparticles Overcomes Drug Resistance in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
This study introduces a biomimetic “nanofusion” platform that integrates the biostability of threose nucleic acids (TNA) with homotypic cell‐membrane cloaking to combat drug‐resistant TNBC. By leveraging a non‐canonical membrane‐fusion pathway for direct cytosolic delivery, the platform bypasses endosomal sequestration. To achieve potent AKT2 silencing
Wei Zheng, Tristan Juin Han Chang, Xinchao Li, Zhongqi Zhou, Chung Tin, Kenward Vong, Pierre Karam, Pik Kwan Lo   +7 more
wiley   +1 more source

Hypotonic enteral electrolyte solutions administered by nasoesophageal tube in continuous flow in dogs dehydrated by water restriction: Part 1

, 2019
The present study assessed and compared the effects of hypotonic enteral electrolyte solutions administered by nasoesophageal tube in continuous flow in dogs submitted to water restriction on packed cell volume; total serum protein and serum osmolarity ...
J.D. Ribeiro Filho (5551319), E.S. Favarato (6825386), L.C. Monteiro (6825374), W.M.F. Dantas (6825365), C.M. Costa (6825377), G.M.M. Silva (6825368), M.O. Silva (6825383), S.R. Alves (6825380), P.A.N. Ermita (6825371)   +8 more
core   +1 more source

Corneal stromal depth of the demarcation line in accelerated corneal cross-linking' with different concentrations of riboflavin solutions [PDF]

, 2019
PurposeThe aim of this study is to compare the effect of different riboflavin solutions (hypotonic and isotonic) used during accelerated corneal cross-linking (CXL) on the mean depth of the demarcation line (DDL) formed in corneal stroma.MethodsThis ...
Kemer, Özlem Evren, Özek, Dilay, Özer, Pınar Altıaylık   +2 more
core   +1 more source

Inflammation Unchecked: Concurrent Kawasaki Disease and Stevens‐Johnson Syndrome in an 18‐Month‐Old Child

Arthritis Care &Research, EarlyView.
Catherine Deffendall, Jodi Backalar, Elizabeth Acevedo Zapata, Adriana Della Porta, Lorin Bibb, Tyler Reese, Charlotte M. Brown   +6 more
wiley   +1 more source

A Biomimetic Dual‐Targeting Nano‐APA‐Editor Reprograms the 3'UTR Landscape for Tongue Squamous Cell Carcinoma Therapy

Advanced Science, EarlyView.
This study unveils a pathogenic axis in oral cancer where NUDT21 suppresses a tumor suppressor network, prominently PTEN, via 3'UTR lengthening. To exploit this transcriptomic vulnerability, we developed a biomimetic Nano‐APA‐editor. By delivering CRISPR/Cas9, we reprogrammed the global 3'UTR landscape, restoring multi‐target tumor suppression and ...
Yiran Ao, Bin Gu, Hui Zhao, Kun Tan, Qin Zhao, Zhengjun Shang   +5 more
wiley   +1 more source

THE BEHAVIOR OF FROG MUSCLE SPINDLE IN HYPER-AND HYPOTONIC SOLUTIONS

The Japanese Journal of Physiology, 1970
1. Isolated muscle spindles in the frog sartorius muscle were perfused in Ringer solutions made hypotonic by reducing NaCl or hypertonic by addition of NaCl, Na2SO4, Na2HPO4+NaH2PO4, sucrose, urea, glycerol, or propylene glycol.2. The frequency of spontaneous discharge at the in situ length of the muscle increased both in hypo- and hypertonic solutions.
openaire   +3 more sources

Cholesterol Laundry of Cell Membrane and Fatty Liver by Detergent Liposomes to Improve Anti‐Cancer Drug Responsiveness of Patient Liver Tissues

Advanced Science, EarlyView.
Cholesterol‐enriched plasma membranes in hepatocellular carcinoma impede drug penetration. Cholesterol (+)‐liposomes act as membrane‐specific detergents, extracting cholesterol and reducing barrier function without cytotoxicity. Following endocytosis, cholesterol transfers from endosomes to liposomes and is metabolized in the ER.
Chansik Kim, Joo Kyung Noh, Sewoom Baek, Seung Eun Yu, Jueun Kim, Seongyo Lee, Youngji Oh, Dai Hoon Han, Seyong Chung, Hak‐Joon Sung   +9 more
wiley   +1 more source

Hypotonic shock mediation by p38 MAPK, JNK, PKC, FAK, OSR1 and SPAK in osmosensing chloride secreting cells of killifish opercular epithelium

, 2005
Udgivelsesdato: March 15 2005Hypotonic shock rapidly inhibits Cl- secretion by chloride cells, an effect that is osmotic and not produced by NaCl-depleted isosmotic solutions, yet the mechanism for the inhibition and its recovery are not known.
Ossum, Carlo Gunnar, Marshall, W. S., Hoffmann, Else Kay   +2 more
core   +1 more source

Targeting the HSPA8‐CMA‐ATP6V1A Axis Triggers Lysosomal Hyperacidification and Catastrophic Vacuolation in Prostate Cancer

Advanced Science, EarlyView.
Our experimental evidence supports a model in which ALO targets the HSPA8‐CMA‐ATP6V1A axis to induce lysosomal hyperacidification and initiate osmotic and lipidomic stress. These changes are associated with LMP and loss of lysosomal integrity in prostate cancer cells.
Bingzheng An, Ze Gao, Shuo Chen, Liwei Meng, Chen Zhang, Kefan Song, Haochen Cui, Lei Yan, Zhiqing Fang   +8 more
wiley   +1 more source