Results 81 to 90 of about 16,203 (292)

Hypotonic shock affects the membrane localisation of 4.1R, and promotes the 4.1R/ICln interaction.

, 2014
(A) Single confocal plane of a cell expressing the membrane marker CFP-mem (Cm) and the Y-4.1R135 protein acquired in the hypertonic (hyper) and hypotonic (hypo 10′) extracellular solutions.
Valeria Rossetti (641509), Davide Marchesi (641510), Maura Francolini (367439), Claudia Bazzini (108605), Simona Rodighiero (108607), Davide Civello (641507), Markus Paulmichl (108614), Chiara Zanoni (641508), Lorena Benedetti (641506), Maria Lisa Garavaglia (108603), Giuliano Meyer (108615)   +10 more
core   +1 more source

PIEZO1 is Required for Acute Myeloid Leukemia Progression and Leukemia Stem Cell Maintenance via HIF1A‐SLC7A11 Axis‐Mediated Ferroptosis Defense

Advanced Science, EarlyView.
This study identifies the mechanosensor PIEZO1 as a key factor in promoting acute myeloid leukemia progression and uncovers a ferroptosis defense system mediated by PIEZO1‐HIF1A‐SLC7A11 axis that is essential for leukemia stem cell maintenance. This ferroptotic defense system may represent a unique vulnerability for leukemia stem cells, providing a ...
Tiantian Zhang, Ziyan Cao, Kexin Gao, Shuxin Yao, Yanbing Zheng, Manman Cui, Rong Yin, Guoqiang Han, Jin Hu, Chengyi Wang, Haojian Zhang   +10 more
wiley   +1 more source

Tension pores in cells in hypotonic solution

, 2019
V zaključni nalogi smo raziskali spreminjanje prostornine celic in pojav napetostnih por celic v različnih hipotoničnih raztopinah vode in gojišča ter v ekvivalentnih hipotoničnih raztopinah saharoze. Pri poskusih smo uporabili epitelne celice kitajskega
Prša, Aleks
core  

Preparation of Asymmetric Vesicles with Trapped CsCl Avoids Osmotic Imbalance, Non-Physiological External Solutions, and Minimizes Leakage

, 2021
The natural asymmetry of cellular membranes influences their properties. In recent years, methodologies for preparing asymmetric vesicles have been developed that rely on cyclodextrin-catalyzed exchange of lipids between donor lipid multilamellar ...
Ming-Hao Li (547413), Ming-Hao Li, Daniel P. Raleigh, Erwin London (105060), Daniel P. Raleigh (635276), Erwin London   +5 more
core   +1 more source

A Non‐Canonical Role of SMAD4 in Regulating 3D Genome Architecture to Inhibit Lung Squamous Cell Carcinoma Development

Advanced Science, EarlyView.
SMAD4 is identified as a guardian of 3D genome architecture in lung squamous cell carcinoma. Loss of SMAD4 unleashes EP300 at chromatin loop anchors, strengthening enhancer–promoter looping and H3K27ac at the SOX2 locus to drive aberrant SOX2 activation and tumor cell proliferation.
Qian Tang, Chen Lian, Xinyan Han, Xuhan Zhang, Zihan Wang, Boyu Wang, Taoyu Zhu, Xinrui Lin, Xiaolei Wang, Yaping Xu, Manyu Xiao, Zijin Wang, Junming Li, Silin Chen, Yunze Wang, Yufei Liu, Songsong Li, Zuolin Shen, Xi Lu, Xueqi Han, Yilu Zhou, Mingyang Xiao, Jiayi Ran, Xiaoran Cao, Xinyi Xu, Hugo Sámano‐Sánchez, Alfredo Rodríguez, Lian Wang, Shuifang Chen, Zhanyu Xu, Shirong Zhang, Nuo Yang, Yong Tang, Jian Liu   +33 more
wiley   +1 more source

Pathological Mechanism‐Inspired Biomimetic Nano‐Senotherapy for Reversing Experimental Atherosclerosis in ApoE−/− Mice

Advanced Science, EarlyView.
The biomimetic self‐assembly nanomedicine reversing atherosclerosis via senotherapy strategy. ABSTRACT The greatest challenge in atherosclerosis (AS) management lies in achieving lesion reversal, not merely slowing progression. Senescent cell accumulation—driven by continuous generation and apoptotic resistance—perpetuates plaque pathology and ...
Yuhan Tian, Yanrui Yang, Qiuyu Li, Ying Hu, Qin Hu, Shasha Ran, Siyu Zhou, Xiujuan Yang, Shanshan Li, Qixiong Zhang   +9 more
wiley   +1 more source

Intravenous postoperative fluid prescriptions for children: A survey of practice

BMC Surgery, 2008
Background Postoperative deaths and neurological injury have resulted from hyponatraemia associated with the use of hypotonic saline solutions following surgery.
Ali Tariq, Hall Tim, Davies Polly, Lakhoo Kokila   +3 more
doaj   +1 more source

Intracellular Acidification Inhibits the Activation of Cl- Channels Induced by a Hypotonic Shock in Opossum Kidney Cells [PDF]

, 1993
Applying the patch-clamp technique to cultured opossum kidney (OK) cells, we investi­gated effects of acid on the activation of Cl- channels induced by a hypotonic shock (half osmolarity).
Yoshiaki MORI, Mamoru FUJIMOTO, Manabu KUBOKAWA   +2 more
core  

Seminal plasma differentially alters the resistance of dog, ram and boar spermatozoa to hypotonic stress.

, 2018
International audienceDuring ejaculation and the deposition in the female genital tract, spermatozoa undergo hypo-osmotic stress and need to withstand it for optimal fertility.
Tsikis, Guillaume, Reynaud, Karine, Stéphane Ferchaud, Xavier Druart, Ferchaud, Stéphane, Guillaume Tsikis, Druart, Xavier, Karine Reynaud   +7 more
core   +1 more source

Tumor‐Specific Delivery of CD28 siRNA via Lyso‐PC C‐16 Modified Lipid Nanoparticles Overcomes Anti‐PD‐1 Resistance by Remodeling Tumor Microenvironment

Advanced Science, EarlyView.
This study develops 16:0 LPC‐modified lipid nanoparticles (LPC‐LNPs) with cancer cell specificity by exploiting altered tumor lipid metabolism. LPC‐LNPs encapsulating Cd28 small interfering RNA (LPC‐LNP‐Cd28) knock down cancer cell CD28 without affecting T cells, inflame the tumor microenvironment, and overcome anti‐PD‐1 resistance.
Yangyang Chai, Keyu Wang, Jiali Fang, Shaorui Jia, Yansong Shi, Wanfeng Gao, Xinpeng Liu, Jiaqiang Li, Zenghui Cui, Yazhi Qian, Xiaosu Chen, Dan Ding, Xuetao Cao   +12 more
wiley   +1 more source