Results 91 to 100 of about 17,899 (259)

NOR‐1 Overexpression Elevates Myoglobin Expression via PERM1 and Enhances Mitochondrial Function and Endurance in Skeletal Muscles of Aged Mice

The FASEB Journal, Volume 39, Issue 8, 30 April 2025.
Skeletal muscle expression of the nuclear receptor NOR‐1 is highly responsive to exercise but diminished in aged mice. The overexpression of NOR‐1 results in a PERM1‐dependent enhancement of myoglobin alongside enhanced gene expression of several regulators of oxidative metabolism and markers of elevated autophagy.
Hector G. Paez, Christopher R. Pitzer, Peter J. Ferrandi, Junaith S. Mohamed, Stephen E. Alway   +4 more
wiley   +1 more source

Xanthine calculi in a patient with Lesch-Nyhan syndrome and factor V Leiden treated with allopurinol: case report

BMC Pediatrics, 2018
Background Lesch-Nyhan syndrome is a rare inborn error of purine metabolism marked by a complete deficiency of the enzyme hypoxanthine-guanine phosphoribosyltransferase (HPRT).
Lisa B. E. Shields, Dennis S. Peppas, Eran Rosenberg   +2 more
doaj   +1 more source

Xanthine oxidase activity in thiopurine curative Chinese inflammatory bowel disease patients

Pharmacology Research & Perspectives, 2021
Xanthine oxidase (XO) competes with thiopurine S‐methyltransferase (TPMT) and hypoxanthine guanine phosphoribosyltransferase (HPRT) to metabolize azathioprine (AZA)/6‐mercaptopurine (6‐MP) in vivo.
Liang Ding, Fang‐bin Zhang, Hui Liu, Xiang Gao, Hui‐chang Bi, Ling Huang, Xue‐ding Wang, Bai‐li Chen, Yu Zhang, Chuanzhu Lv, Pin‐jin Hu, Min Huang   +11 more
doaj   +1 more source

Discovery, design, and engineering of enzymes based on molecular retrobiosynthesis

mLife, Volume 4, Issue 2, Page 107-125, April 2025.
Abstract Biosynthesis—a process utilizing biological systems to synthesize chemical compounds—has emerged as a revolutionary solution to 21st‐century challenges due to its environmental sustainability, scalability, and high stereoselectivity and regioselectivity.
Ancheng Chen, Xiangda Peng, Tao Shen, Liangzhen Zheng, Dong Wu, Sheng Wang   +5 more
wiley   +1 more source

IMPDH2 and HPRT expression and a prognostic significance in preoperative and postoperative patients with osteosarcoma

Scientific Reports, 2021
Osteosarcoma is one of the most aggressive bone tumors in children and adolescents. Development of effective therapeutic options is still lacking due to the complexity of the genomic background.
Parunya Chaiyawat, Areerak Phanphaisarn, Nutnicha Sirikaew, Jeerawan Klangjorhor, Viraporn Thepbundit, Pimpisa Teeyakasem, Phichayut Phinyo, Dumnoensun Pruksakorn, Jongkolnee Settakorn   +8 more
doaj   +1 more source

Downregulation of NAD Kinase Expression in β‐Cells Contributes to the Aging‐Associated Decline in Glucose‐Stimulated Insulin Secretion

Aging Cell, Volume 24, Issue 4, April 2025.
Adequate NADK/NADK2 level is essential to the proper functioning of redox and folate cycles and the purine biosynthesis pathway, and as well as maintenance of GSIS response. During aging, diminished NADK/NADK2 expression alters the metabolic status quo, increasing AICAR production. The latter activates AMPK and suppresses GSIS.
Guan‐Jie Li, Mei‐Ling Cheng, Yu‐Ting Lin, Yu‐Hsuan Ho, Gigin Lin, Chih‐Yung Chiu, Hung‐Yao Ho   +6 more
wiley   +1 more source

Purine and Pyrimidine Salvage in Whole Rat Brain. Utilization of ATP-derived Ribose-1-Phosphate and 5-Phosphoribosyl-1-pyrophosphate Generated in Experiments with Dialyzed Cell-free Extracts [PDF]

, 2002
The object of this work stems from our previous studies on the mechanisms responsible of ribose-1-phosphate- and 5-phosphoribosyl-1-pyrophosphate-mediated nucleobase salvage and 5-fluorouracil activation in rat brain (Mascia, L., Cappiello M., Cherri, S.,
BARSOTTI C, IPATA, PIERO LUIGI, TOZZI, MARIA GRAZIA   +2 more
core   +1 more source

Nucleotide Metabolism in Plants [PDF]

, 2020
[no abstract ...
Herde, Marco, Witte, Claus-Peter
core   +2 more sources

Oleanolic acid blocks the purine salvage pathway for cancer therapy by inactivating SOD1 and stimulating lysosomal proteolysis

Molecular Therapy: Oncolytics, 2021
Metabolic reprogramming is a core hallmark of cancer and is key for tumorigenesis and tumor progression. Investigation of metabolic perturbation by anti-cancer compounds would allow a thorough understanding of the underlying mechanisms of these agents ...
Dan Liu, Xing Jin, Guanzhen Yu, Mingsong Wang, Lei Liu, Wenjuan Zhang, Jia Wu, Fengying Wang, Jing Yang, Qin Luo, Lili Cai, Xi Yang, Xisong Ke, Yi Qu, Zhenye Xu, Lijun Jia, Wen-Lian Chen   +16 more
doaj  

Isoensyme der Hypoxanthin-Guanin-Phosphoribosyltransferase in menschlichen Erythrocyten [PDF]

Clinical Chemistry and Laboratory Medicine, 1972
Es konnte gezeigt werden, das Hypoxanthin-Guanin-Phosphoribosyltransferase des menschlichen Erythrocyten 4 Isoenzyme besitzt. Diese Isoenzyme, die sich durch ihre elektrophoretischen Eigenschaften auf Polyacrylamidgel unterscheiden, zeigen immunologisch im Doppeldiffusionstest komplette Identitat. Als Ursache fur die Existenz dieser Isoenzymc wird eine
MÜLLER, M. M., DOBROVITS, H., STEMBERGER, H.   +2 more
openaire   +2 more sources