Proceedings of the National Academy of Sciences of the United States of America, 1973 14 Clones resistant to 8-azaguanine, isolated from mutagenically treated cultured cells from Chinese hamsters, were tested for loss of enzymic and immunological activities of hypoxanthine: guanine phosphoribosyltransferase.
A. Beaudet, D. Roufa, C. Caskey
semanticscholar +2 more sources
Phenotypic variation among seven members of one family with deficiency of hypoxanthine-guanine phosphoribosyltransferase. [PDF]
Mol Genet Metab, 2013 Ceballos-Picot I +9 more
europepmc +2 more sources
Pyrophosphate activation in hypoxanthine--guanine phosphoribosyltransferase with transition state analogue. [PDF]
Biochemistry, 2010 Deng H +3 more
europepmc +3 more sources
DNA Repair and Mutagenesis of ADP-Ribosylated DNA by Pierisin [PDF]
ToxinsPierisin is a DNA-targeting ADP-ribosyltransferase found in cabbage white butterfly (Pieris rapae). Pierisin transfers an ADP-ribosyl moiety to the 2-amino group of the guanine residue in DNA, yielding N2-(ADP-ribos-1-yl)-2′-deoxyguanosine (N2-ADPR-dG ...
Masanobu Kawanishi +3 more
doaj +2 more sources
The Effect of Two Weeks of High-intensity Interval Training on Salvage nucleotide pathway [PDF]
فیزیولوژی ورزش و فعالیت بدنی, 2022 Purpose: The effects of exercise adaptation on improving the purine nucleotides components are inevitable, and physical activity improves the purine nucleotide salvage pathway.
Abbas Ghanbari Niaki +1 more
doaj +1 more source
Purine Metabolism and Dystonia: Perspectives of a Long-Promised Relationship. [PDF]
Ann NeurolPurine pool imbalance in purine metabolism disorders, such as Lesch–Nyhan disease, intersects with dystonia pathogenesis. The recent discovery of gain‐of‐function IMPDH2 pathogenic variants in patients with prominent dystonic manifestations provides new insights into the link between dystonia and purinergic system defects.
Sorrentino U +4 more
europepmc +2 more sources
FEBS Letters, 2022 Hypoxanthine‐guanine phosphoribosyltransferase (HGPRT) is a key enzyme in the purine salvage pathway. Here, the reverse reaction of HGPRT from the thermophilic bacterium Hungateiclostridium thermocellum was studied in the presence of IMP and ...
S. Ueda, T. Hirata, S. Sakasegawa
semanticscholar +1 more source
Pathogens, 2023 Schistosomiasis is one of the most important human helminthiases worldwide. Praziquantel is the current treatment, and no vaccine is available until the present.
Ana Carolina Maragno Fattori +10 more
doaj +1 more source
Complement C3a and C5a Receptors Are Presented in Mouse Sciatic and Human Sural Nerves and Selectively Modulate the Neuronal Function of Large-Caliber Fibers in Mice. [PDF]
J NeurochemNeural complement receptors modulate peripheral nerve function. C3aR is localized to paranodal glia, while C5aR1 is found in unmyelinated fibers of human and mouse peripheral nerves. Expression of both receptors in the sciatic nerve is confirmed by qPCR and Western blot.
Berkowitz S +6 more
europepmc +2 more sources
Adeno‐associated virus serotype 2 capsid variants for improved liver‐directed gene therapy
Hepatology, EarlyView., 2022 Abstract Background and Aims Current liver‐directed gene therapies look for adeno‐associated virus (AAV) vectors with improved efficacy. With this background, capsid engineering is explored. Whereas shuffled capsid library screenings have resulted in potent liver targeting variants with one first vector in human clinical trials, modifying natural ...
Nadja Meumann +25 more
wiley +1 more source