Results 61 to 70 of about 14,819 (239)

TRP canonical 4 and/or 5 channel inhibition reduces aversion‐ and increases reward‐responding in chronically stressed mice

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Pharmacological inhibition of TRPC4 and/or TRPC5 channels reduces Pavlovian aversion memory in stressed mice and reduces amygdala reactivity to aversion in humans with depression. The aims of this mouse study were to improve understanding of these anxiolytic processes, determine whether there are corrective effects on ...
Giulia Poggi, Deniz Queisser, Alena Senn, Hannes Sigrist, Diana Kúkeľová, Lorraine Madur, Nagiua Cuomo‐Haymour, Mélisse Robert, Sophie Schmid, Adrián Portalés, Sophie Simard, Naguib Mechawar, Bastian Hengerer, Stefan Just, Christopher R. Pryce   +14 more
wiley   +1 more source

Purification and Characterization of Human Hypoxanthine/Guanine Phosphoribosyltransferase [PDF]

European Journal of Biochemistry, 1977
Human hypoxanthine/guanine phosphoribosyltransferase (EC 2.4.2.8) was purified from red blood cells by the following two methods. Method A includes (a) elimination of hemoglobin by DEAE‐cellulose, (b) DEAE‐Sephadex chromatography, (c) specific elution of the enzyme from CM‐Sephadex by pyrophosphate and (d) Sephadex G‐100 gel filtration.
H, Muensch, A, Yoshida
openaire   +2 more sources

Induction of Mineralization [PDF]

, 2014
Vascular mineralization contributes to the high cardiovascular morbidity and mortality in patients who suffer from chronic kidney disease and in individuals who have undergone solid organ transplantation. The immunosuppressive regimen used to treat these
Giet, Markus van der, Höhne, Matthias, Prüfer, Jasmin, Prüfer, Nicole, Schuchardt, Mirjam, Tölle, Markus, Zidek, Walter   +6 more
core   +1 more source

Achilles tenocytes from diabetic and non diabetic donors exposed to hyperglycemia respond differentially to inflammatory stimuli and stretch

Journal of Anatomy, EarlyView.
Scheme depicting the experimental set up of the study. Achilles tendons and tenocytes were isolated from heterozygous (fa/+, non diabetic: non DMT2) and homozygous (fa/fa, diabetic: DMT2) Zucker Diabetic Fatty (ZDF) rats. Tendon degeneration, collagen type 1 alpha 1 chain (COL1A1) and alpha smooth muscle actin (αSMA) expression was determined in rat ...
Nils Fleischmann, Sarah Hofmann, Clemens Gögele, Eva Frank, Christian Werner, Maria Kokozidou, Bernd Hoffmann, Jens Konrad, Gundula Schulze‐Tanzil   +8 more
wiley   +1 more source

Description of the Molecular and Phenotypic Spectrum of Lesch-Nyhan Disease in Eight Chinese Patients

Frontiers in Genetics, 2022
Background: Lesch-Nyhan disease (LND) is a rare disorder involving pathogenic variants in the HPRT1 gene encoding the enzyme hypoxanthine-guanine phosphoribosyltransferase (HGPRT) that result in hyperuricemia, intellectual disability, dystonic movement ...
Lu Li, Xiaohui Qiao, Fei Liu, Jingjing Wang, Huijun Shen, Haidong Fu, Jian-Hua Mao   +6 more
doaj   +1 more source

Metabolomic profiling of the synergistic effects of melittin in combination with cisplatin on ovarian cancer cells [PDF]

, 2017
Melittin, the main peptide present in bee venom, has been proposed as having potential for anticancer therapy; the addition of melittin to cisplatin, a first line treatment for ovarian cancer, may increase the therapeutic response in cancer treatment via
Alonezi, Sanad, Clements, Carol J., Dufton, Mark J., Ferro, Valerie A., Jeon, Jong-Woon, Park, Jin-Kyu, Parkinson, John A., Tusiimire, Jonans, Wallace, Jennifer, Watson, David G., Young, Louise C.   +10 more
core   +1 more source

Antioxidant supplementation blunts the proteome response to 3 weeks of sprint interval training preferentially in human type 2 muscle fibres

The Journal of Physiology, EarlyView.
Abstract figure legend Sprint interval training (SIT) is a popular time‐efficient type of endurance training. Healthy young men performed nine SIT sessions (4–6 × 30 s all‐out cycling sprints) over 3 weeks while being supplemented with antioxidants (high doses of vitamins C and E) or placebo. Muscle biopsies taken before and after the first SIT session
Victoria L. Wyckelsma, Marta Murgia, Sigitas Kamandulis, Stefano Gastaldello, Marius Brazaitis, Audrius Snieckus, Nerijus Eimantas, Mati Pääsuke, Sebastian Edman, William Apro, Daniel C. Andersson, Håkan Westerblad, Tomas Venckunas   +12 more
wiley   +1 more source

Die Kaltplasma‐Technologie in der Behandlung von Menschen mit chronischen Wunden

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, Volume 24, Issue 2, Page 216-229, February 2026.
Zusammenfassung Chronische Wunden stellen eine erhebliche Belastung sowohl für Patienten als auch für Gesundheitssysteme dar. Die Kaltplasma‐Technologie hat sich bei der Behandlung von Menschen mit chronischen Wunden in den letzten Jahren zunehmend etabliert. Mittlerweile sind verschiedene Kaltplasma‐Geräte verfügbar.
Sander Bekeschus, Lars Boeckmann, Alexander Thiem, Steffen Emmert   +3 more
wiley   +1 more source

Prioritization of Deleterious Variations in the Human Hypoxanthine-Guanine Phosphoribosyltransferase Gene

Medical Laboratory Journal, 2018
Background and Objectives: Non-synonymous single nucleotide polymorphisms are typical genetic variations that may potentially affect the structure or function of expressed proteins, and therefore could be involved in complex disorders.
Semira Kheiri, Mahdieh Safarzad, Mohammad Shariati, Hoda Sohrabi   +3 more
doaj  

Striatal neurodevelopment is dysregulated in purine metabolism deficiency and impacts DARPP-32, BDNF/TrkB expression and signaling: new insights on the molecular and cellular basis of Lesch-Nyhan Syndrome. [PDF]

PLoS ONE, 2014
Lesch-Nyhan Syndrome (LNS) is a neurodevelopmental disorder caused by mutations in the gene encoding the purine metabolic enzyme hypoxanthine-guanine phosphoribosyltransferase (HPRT).
Ghiabe-Henri Guibinga, Nikki Barron, William Pandori   +2 more
doaj   +1 more source