Results 171 to 180 of about 55,919 (216)

Facilitated Purification of Hypoxanthine Phosphoribosyltransferase

Hoppe-Seyler´s Zeitschrift für physiologische Chemie, 1976
Three major approaches to the complete purification of hypoxanthine phosphoribosyltransferase from human erythrocytes and rat brain are described. Preparative isoelectric focusing which has been used for the isolation of the human enzyme was not fully successful in the case of rat brain.
W, Gutensohn, M, Huber, H, Jahn
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Hypoxanthine Transport in Human Erythrocytes

1980
De novo synthesis of purines does not appear to take place in mature human erythrocytes because the enzymes for the pathway are absent1. Therefore purine bases should be normally have to be supplied exogenously to erythrocytes.
GIACOMELLO, Alessandro, SALERNO, Costantino   +1 more
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SIDS and Hypoxanthine

Pediatrics, 1991
The study by Rognum and Saugstad concerning elevated hypoxanthine levels in the vitreous humor of victims of Sudden Infant Death Syndrome (SIDS) made a laudable attempt to correct for postmortem increases in this marker of hypoxia, but I am concerned that the authors have not sufficiently recognized some characteristics of SIDS that could have ...
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Transformation of the gene for hypoxanthine phosphoribosyltransferase

Somatic Cell Genetics, 1979
Purified DNA from wild-type Chinese ovary (CHO) cells has been used to transform three hypoxanthine phosphoribosyltransferase (HPRT) deficient murine cell mutants to the enzyme positive state. Transformants appeared at an overall frequency of 5 x 10(-8) colonies/treated cell and expressed CHO HPRT activity as determined by electrophoresis.
L H, Graf, G, Urlaub, L A, Chasin
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Hypoxanthine nucleotides and muscular contraction

Biochimica et Biophysica Acta, 1963
Abstract 1. 1. Experiments have been devised to test the suggestion of a number of investigators that the interconversion of adenine and hypoxanthine nucleotides may provid the energy for muscular contraction. 2. 2. Several methods for the assay of very small amounts of these nucleotides in muscle extracts have been examined.
D F, CAIN, M J, KUSHMERICK, R E, DAVIES
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Transport of hypoxanthine by human diploid skin fibroblasts deficient in hypoxanthine-guanine phosphoribosyltransferase

Experimental Cell Research, 1977
Summary Transport of purine bases and nucleosides by a variety of mammalian cell lines is generally accomplished by facilitated diffusion, a non-concentrative, saturable process. However, previous investigators have been unable to detect a saturable component for the transport of hypoxanthine by human fibroblasts deficient in hypoxanthine-guanine ...
E, Murphy, M J, Holland, R P, Cox
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Hypoxanthine

Exercise and Sport Sciences Reviews, 2015
Cardiorespiratory and biochemical indicators typically used by contemporary elite athletes seem to have limited applicability. According to some recent studies, purine metabolism better reflects exercise response and muscle adaptation in this group.
Jacek, Zieliński, Krzysztof, Kusy
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Uptake of Hypoxanthine in Human Erythrocytes

1977
The concentration of oxypurines in the plasma is known to be rather low (10 – 40 μM) (6). Since the formation of purines is accomplished to a great extent by the liver (7, 8), a transport of purines by erythrocytes from liver to tissues with limited or no capacity of de novo purine synthesis has been postulated (1, 3).
M M, Müller, G, Falkner
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The Spectrum of Hypoxanthine-guanine Phosphoribosyltransferase Deficiency

QJM: An International Journal of Medicine, 1973
The spectrum of clinical manifestations of hypoxanthine-guanine phosphoribosyltransferase (HGPRTase) deficiency is presented by reference to eight patients from five kindred. These patients illustrate the range of associated neurological findings, together with the variety of presentation and complications due to the associated over-production of urate.
Emmerson, B. T., Thompson, L.
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Electrochemical oxidation of hypoxanthine

Journal of Electroanalytical Chemistry and Interfacial Electrochemistry, 1981
Abstract The electrochemical oxidation of hypoxanthine (6-oxypurine) in aqueous solution has been studied. The evidence strongly supports the view that hypoxanthine is initially electrooxidized in a 2 e −2H + reaction to give 6,8-dioxypurine. The latter compound is more easily oxidized than hypoxanthine and is immediately further electrooxidized to ...
Arnold C. Conway, R.N. Goyal, Glenn Dryhurst   +2 more
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