Results 21 to 30 of about 103,245 (286)

Ischemic preconditioning attenuates portal venous plasma concentrations of purines following warm liver ischemia in man [PDF]

, 2005
Background/Aims: Degradation of adenine nucleotides to adenosine has been suggested to play a critical role in ischemic preconditioning (IPC). Thus, we questioned in patients undergoing partial hepatectomy whether (i) IPC will increase plasma purine ...
Chouker, A., Dugas, Martin, Heizmann, O., Martignoni, A., Messmer, K., Peter, K., Rau, H. G., Schauer, R. J., Thiel, M., Volk, A.   +9 more
core   +1 more source

A study of the effects of exercise on the urinary metabolome using normalisation to individual metabolic output [PDF]

, 2015
Aerobic exercise, in spite of its multi-organ benefit and potent effect on the metabolome, has yet to be investigated comprehensively via an untargeted metabolomics technology.
Anthony, Nahoum, Blackburn, Gavin, Daskalaki, Evangelia, Kalna, Gabriela, Watson, David, Zhang, Tong   +5 more
core   +2 more sources

Adeno‐associated virus serotype 2 capsid variants for improved liver‐directed gene therapy

Hepatology, EarlyView., 2022
Abstract Background and Aims Current liver‐directed gene therapies look for adeno‐associated virus (AAV) vectors with improved efficacy. With this background, capsid engineering is explored. Whereas shuffled capsid library screenings have resulted in potent liver targeting variants with one first vector in human clinical trials, modifying natural ...
Nadja Meumann, Marti Cabanes‐Creus, Moritz Ertelt, Renina Gale Navarro, Julie Lucifora, Qinggong Yuan, Karin Nien‐Huber, Ahmed Abdelrahman, Xuan‐Khang Vu, Liang Zhang, Ann‐Christin Franke, Christian Schmithals, Albrecht Piiper, Annabelle Vogt, Maria Gonzalez‐Carmona, Jochen T. Frueh, Evelyn Ullrich, Philip Meuleman, Steven R. Talbot, Margarete Odenthal, Michael Ott, Erhard Seifried, Clara T. Schoeder, Joachim Schwäble, Leszek Lisowski, Hildegard Büning   +25 more
wiley   +1 more source

Late diagnosis of Lesch–Nyhan disease complicated with end-stage renal disease and tophi burst: a case report

Renal Failure, 2020
Background Lesch–Nyhan disease (LND) is a rare X-linked recessive inborn error of purine metabolism. Late diagnosis of LND may cause significant morbidity. LND cases have never been reported in Indonesia.
Cahyani Gita Ambarsari, Daffodilone Cahyadi, Lenny Sari, Oryza Satria, Felly Sahli, Thyrza Laudamy Darmadi, Agustina Kadaristiana   +6 more
doaj   +1 more source

Study on the diagnosis of gout with xanthine and hypoxanthine

Journal of clinical laboratory analysis (Print), 2019
Hyperuricemia is the only biochemical index in the classification of acute gouty arthritis in American Rheumatism Association 1977 and the main basis of clinical diagnosis for most doctors.
Yu Wang, Miao-Han Deng, B. Deng, L. Ye, Xiaofan Fei, Zhigang Huang   +5 more
semanticscholar   +1 more source

Metabolite Ratios as Quality Indicators for Pre-Analytical Variation in Serum and EDTA Plasma

Metabolites, 2021
In clinical diagnostics and research, blood samples are one of the most frequently used materials. Nevertheless, exploring the chemical composition of human plasma and serum is challenging due to the highly dynamic influence of pre-analytical variation ...
Sven Heiling, Nadine Knutti, Franziska Scherr, Jörg Geiger, Juliane Weikert, Michael Rose, Roland Jahns, Uta Ceglarek, André Scherag, Michael Kiehntopf   +9 more
doaj   +1 more source

Differential chemosensitivity to antifolate drugs between RAS and BRAF melanoma cells. [PDF]

, 2014
BACKGROUND: The importance of the genetic background of cancer cells for the individual susceptibility to cancer treatments is increasingly apparent.
Arozarena, Imanol, Erice, O., Ferguson, J., Goicoechea, I., Margison, G.P., Wellbrock, C.   +5 more
core   +2 more sources

Hypoxia modulates the purine salvage pathway and decreases red blood cell and supernatant levels of hypoxanthine during refrigerated storage

Haematologica, 2017
Hypoxanthine catabolism in vivo is potentially dangerous as it fuels production of urate and, most importantly, hydrogen peroxide. However, it is unclear whether accumulation of intracellular and supernatant hypoxanthine in stored red blood cell units is
T. Nemkov, K. Sun, J. Reisz, Anren Song, T. Yoshida, A. Dunham, M. Wither, R. Francis, R. Roach, Monika Dzieciatkowska, S. Rogers, A. Doctor, Anastasios G. Kriebardis, M. Antonelou, I. Papassideri, C. Young, Tiffany A. Thomas, K. Hansen, S. Spitalnik, Yang Xia, J. Zimring, E. Hod, A. D’Alessandro   +22 more
semanticscholar   +1 more source

Molybdenum-Cofactor Deficiency and Seizures

Pediatric Neurology Briefs, 1993
The clinical, biochemical, and neuropathological findings in two neonates with molybdenum-cofactor deficiency presenting with convulsions are reported from the Academic Medical Center, Amsterdam, The Netherlands.
J Gordon Millichap
doaj   +1 more source

Select pyrimidinones inhibit the propagation of the malarial parasite, Plasmodium falciparum [PDF]

, 2009
Plasmodium falciparum, the Apicomplexan parasite that is responsible for the most lethal forms of human malaria, is exposed to radically different environments and stress factors during its complex lifecycle.
Annette N. Chiang, Banumathy, Billy W. Day, Botha, Brian P. Mead, Chiu, Corinne Schneider, Craig, David A. Fidock, Donna M. Huryn, Ekland, Fernandez-Saiz, Fewell, Fewell, Fewell, Fidock, Frydman, Hartl, Hunt, Jeffrey L. Brodsky, Jiang, Juan-Carlos Valderramos, Maier, Matambo, Mayer, McClellan, McKerrow, Michael G. Klein, Midorikawa, Nadeau, Noedl, Pavithra, Pecoul, Peter Wipf, Raghavan Balachandran, Raj J. Chovatiya, Ramya, Rodina, Samantha L. Bell, Shonhai, Shonhai, Sidhu, Tang, Tonkin, Wellems, Werner, Wright, Xiaojiang S. Chen, Youker   +48 more
core   +1 more source