Results 41 to 50 of about 55,919 (216)

Non-targeted Metabolomics Analysis of the Effects of Arabinogalactan on the Metabolites of Akkermansia muciniphila

Shipin gongye ke-ji, 2022
Among many plant polysaccharides, arabinogalactan had the best growth-promoting effect on Akkermansia muciniphila (Akk) model strain (DSM 22959). In order to further explore the influence of arabinogalactan on Akk metabolites, arabinogalactan was used as
Xirui FENG, Yanshi MA, Xiaoling WU, Xiangli KONG, Tianyang ZHANG, Dmitrii LOKHOV, Olga SERKOVA, Xiaoxi XU   +7 more
doaj   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Quality Thresholds for Angiogenesis Under Acoustic Manipulation in Engineered Vascular Tissues

Advanced Science, EarlyView.
Defined biological and physical quality thresholds achieved through acoustic manipulation regulate cellular alignment and spatial organization, promoting self‐assembling vasculature, extracellular matrix deposition, and angiogenic responses, thereby establishing critical acoustic patterning requirements for engineered vascular tissue development in ...
Oscar O'Dwyer Lancaster‐Jones, Russell Quinn, Niloofar Khoshdel Rad, Kilian Paul, Andrea Frank, Daniela F. Duarte Campos   +5 more
wiley   +1 more source

Fast Protein and Metabolites (Nucleotides and Nucleosides) Liquid Chromatography Technique and Chemical Sensor for the Assessment of Fish and Meat Freshness

Chemosensors, 2023
Fast protein and metabolite liquid chromatography (FPLMC) was introduced years ago to enable the easy separation of high-molecular compounds such as proteins from small molecules and the identification of the low-molecular substances.
Artur Kuznetsov, Aleksandr Frorip, Alar Sünter, Nensi Kasvand, Vadim Korsakov, Georgii Konoplev, Oksana Stepanova, Linda Rusalepp, Dea Anton, Tõnu Püssa, Mati Roasto, Liubov Abramova, Andrey Kozin, Lauri Toom, Soeren Hirsch, Nikolay Mukhin   +15 more
doaj   +1 more source

Engineering‐Modulated Molybdenum Enzymes Strategy for Tumor‐Specific Metabolic‐Immunotherapy

Advanced Science, EarlyView.
Biodegradable molybdenum sulfide nanoparticles were synthesized via a one‐pot strategy to increase molybdenum enzyme activity and thus effectively potentiate anti‐tumor immunity by integrating molybdenum‐based metalloimmunotherapy with hydrogen sulfide gas therapy.
Xiaoxiao Pan, Zifan Pei, Jie Wu, Nan Jiang, Qian Li, Yuqi Yang, Jie Cao, Yechen Huang, Shumin Sun, Qialu Du, Zhicheng Liu, Lin Zhang, Fei Gong, Jinhua Zhou, Liang Cheng   +14 more
wiley   +1 more source

Evaluation of the Uricogenic Effect of Hypoxanthine and the Hypoxanthine‐Lowering Process of Shrimp (Metapenaeus ensis)

Food Frontiers
One of the main reasons for hyperuricemia is high purine intake and restricting the intake of high purine food is the main management for avoiding hyperuricemia.
Wanqian Sha, Lu xiao, Chunlin Tao, Chuanli Hou, Yanbo Wang, Huilin Liu, Jiaoyan Ren   +6 more
doaj   +1 more source

Integrative Analysis of Metabolomics and Transcriptomics Data Identifies Prognostic Biomarkers Associated With Oral Squamous Cell Carcinoma

Frontiers in Oncology, 2021
BackgroundOral squamous cell carcinoma (OSCC) is the most malignant neoplasm in oral cancer. There is growing evidence that its progression involves altered metabolism.
Lihua Zuo, Zhuo Chen, Lihuang Chen, Jian Kang, Yingying Shi, Liwei Liu, Shuhua Zhang, Qingquan Jia, Yi Huang, Zhi Sun   +9 more
doaj   +1 more source

Single‐Cell Transcriptomics and Metabolomics Reveal Glutamate Dehydrogenase as a Central Regulator of Nitrogen Metabolic Remodeling During Alkalinity Adaptation in Crustaceans

Advanced Science, EarlyView.
Single‐cell transcriptomics reveals the cellular response of Macrobrachium hainanense to carbonate alkalinity stress. Alkalinity stress impairs branchial ammonia excretion, induces mitochondrial dysfunction, and drives cell‐type‐specific changes in gills and hemocytes.
Yiting Jin, Zhimin Lv, Chao Bian, Qibin Yang, Na Zhou, Jianguang Qin, Shengming Sun   +6 more
wiley   +1 more source

Repair of Hypoxanthine in DNA Revealed by DNA Glycosylases and Endonucleases From Hyperthermophilic Archaea

Frontiers in Microbiology, 2021
Since hyperthermophilic Archaea (HA) thrive in high-temperature environments, which accelerate the rates of deamination of base in DNA, their genomic stability is facing a severe challenge.
Tan Lin, Likui Zhang, Likui Zhang, Mai Wu, Donghao Jiang, Zheng Li, Zhihui Yang   +6 more
doaj   +1 more source

FLAVIN-HYPOXANTHINE DINUCLEOTIDE

THE JOURNAL OF VITAMINOLOGY, 1957
1. FHD was synthesized from FAD by deamination with nitrous acid and the product was first isolated as barium salt. The yield and purity were, however, unsatisfactory by this method. Therefore, the product was extracted with cresol, followed by transfer in aqueous phase, and by subjecting to column chromatography, FHD was obtained in high purity in ...
openaire   +3 more sources