Foods, 2023 Due to its unique biological composition, aquatic products, especially fish, are extremely perishable compared to other muscle products. Herein, we proposed an artificial nanozyme-based colorimetric detection of hypoxanthine (Hx), the indicator of fish ...
Xiaoming Ma +10 more
doaj +1 more source
Differential regulation of hypoxanthine and xanthine by obesity in a general population
Journal of Diabetes Investigation, 2020 Aims/Introduction Uric acid is synthesized by oxidation of hypoxanthine and xanthine using a catalyzing enzyme, xanthine oxidoreductase (XOR), which can be a source of reactive oxygen species.
Masato Furuhashi +12 more
doaj +1 more source
Metabolite Ratios as Quality Indicators for Pre-Analytical Variation in Serum and EDTA Plasma
Metabolites, 2021 In clinical diagnostics and research, blood samples are one of the most frequently used materials. Nevertheless, exploring the chemical composition of human plasma and serum is challenging due to the highly dynamic influence of pre-analytical variation ...
Sven Heiling +9 more
doaj +1 more source
Adeno‐associated virus serotype 2 capsid variants for improved liver‐directed gene therapy
Hepatology, EarlyView., 2022 Abstract Background and Aims Current liver‐directed gene therapies look for adeno‐associated virus (AAV) vectors with improved efficacy. With this background, capsid engineering is explored. Whereas shuffled capsid library screenings have resulted in potent liver targeting variants with one first vector in human clinical trials, modifying natural ...
Nadja Meumann +25 more
wiley +1 more source
Interplay of 'induced fit' and preorganization in the ligand induced folding of the aptamer domain of the guanine binding riboswitch [PDF]
, 2006 Riboswitches are highly structured elements in the 50-untranslated regions (50-UTRs) of messenger RNA that control gene expression by specifically binding to small metabolite molecules. They consist of an aptamer domain responsible for ligand binding and
Noeske, Jonas +5 more
core +1 more source
Characterizing nanoplastics‐induced stress and its SERS fingerprint in an intestinal membrane model
Nano Select, 2021 Epithelium membranes provide important barrier functions, and it is important to understand how nanoparticle (NP) exposure affects their barrier function.
Qianyun Zhang, Björn M. Reinhard
doaj +1 more source
Biosensors, 2023 In the rapidly evolving field of food science, nanotechnology-based biosensors are one of the most intriguing techniques for tracking meat freshness.
Wen Xia Ling Felicia +5 more
doaj +1 more source
Biochemistry Changes That Occur after Death: Potential Markers for Determining Post-Mortem Interval [PDF]
, 2013 Death is likely to result in very extensive biochemical changes in all body tissues due to lack of circulating oxygen, altered enzymatic reactions, cellular degradation, and cessation of anabolic production of metabolites.
Donaldson, Andrea
core +1 more source
Fatty Acid Oxidation and Meiotic Resumption in Mouse Oocytes [PDF]
, 2009 We have examined the potential role of fatty acid oxidation (FAO) in AMP-activated protein kinase (AMPK)-induced meiotic maturation. Etomoxir and malonyl CoA, two inhibitors of carnitine palmitoyl transferase-1 (CPT1), and thus FAO, blocked meiotic ...
Downs, Stephen +2 more
core +2 more sources
Biosensor measurement of purine release from cerebellar cultures and slices [PDF]
, 2010 We have previously described an action-potential and Ca2+-dependent form of adenosine release in the molecular layer of cerebellar slices. The most likely source of the adenosine is the parallel fibres, the axons of granule cells. Using microelectrode
Wall, Mark J. +2 more
core +2 more sources