Results 31 to 40 of about 55,919 (216)

High-Intensity Interval Training Decreases Resting Urinary Hypoxanthine Concentration in Young Active Men—A Metabolomic Approach

Metabolites, 2019
High-intensity interval training (HIIT) is known to improve performance and skeletal muscle energy metabolism. However, whether the body’s adaptation to an exhausting short-term HIIT is reflected in the resting human metabolome has not been ...
Sina Kistner, Manuela J. Rist, Ralf Krüger, Maik Döring, Sascha Schlechtweg, Achim Bub   +5 more
doaj   +1 more source

Biosynthesis and Genetic Tuning of Guanine Crystals via Metabolic Engineering of Yeast

Angewandte Chemie, EarlyView.
We demonstrate how yeast cells can be harnessed as cellular factories for the synthesis of optically functional guanine crystals, where genetic editing is used to tune crystal size, order and optical properties. This demonstrates a powerful new biosynthetic approach for the development of sustainable and biocompatible optical pigments, which utilizes ...
Jerome N. Janssen, Yahel Fishman, Yi Li, Avital Wagner, Mariela J. Pavan, Zohar Paleiov, Tali Lemcoff, Rotem Lichtenstein‐Wolfheim, Alexander Upcher, Einat Nativ‐Roth, Amir Aharoni, Benjamin A. Palmer   +11 more
wiley   +2 more sources

Hypoxanthine uptake by human erythrocytes [PDF]

FEBS Letters, 1979
It is well established that the uptake of hypoxan- thin, by human erythrocytes is mediated by its incorporation into IMP [ 11. The synthesis of this nucleotide is dependent on the intracellular availability of 5phosphoribosyl o-1-pyrophosphate (PRPP) and on the activity of hypoxanthine-guanine phospho- ribosyltransferase (HGPRT) [ 11.
GIACOMELLO, Alessandro, SALERNO, Costantino   +1 more
openaire   +3 more sources

A ratiometric fluorescent probe for hypoxanthine detection in aquatic products based on the enzyme mimics and fluorescence of cobalt-doped carbon nitride

Food Science and Human Wellness
A ratiometric fluorescent probe for hypoxanthine (Hx) detection was established based on the mimic enzyme and fluorescence characteristics of cobalt-doped graphite-phase carbon nitride (Co doped g-C3N4).
Xin Wang, Chengyi Hong, Zhengzhong Lin, Zhiyong Huang   +3 more
doaj   +1 more source

Surface-Enhanced Raman Analysis of Uric Acid and Hypoxanthine Analysis in Fractionated Bodily Fluids

Nanomaterials, 2023
In recent years, the disease burden of hyperuricemia has been increasing, especially in high-income countries and the economically developing world with a Western lifestyle. Abnormal levels of uric acid and hypoxanthine are associated with many diseases,
Furong Tian, Luis Felipe das Chagas e Silva de Carvalho, Alan Casey, Marcelo Saito Nogueira, Hugh J. Byrne   +4 more
doaj   +1 more source

The Metabolomic Profile of Lymphoma Subtypes: A Pilot Study

Molecules, 2019
Lymphoma defines a group of different diseases. This study examined pre-treatment plasma samples from 66 adult patients (aged 20−74) newly diagnosed with any lymphoma subtype, and 96 frequency matched population controls. We used gas chromatography-
Luigi Barberini, Antonio Noto, Claudia Fattuoni, Giannina Satta, Mariagrazia Zucca, Maria Giuseppina Cabras, Ester Mura, Pierluigi Cocco   +7 more
doaj   +1 more source

Detection of Hypoxanthine from Inosine and Unusual Hydrolysis of Immunosuppressive Drug Azathioprine through the Formation of a Diruthenium(III) System

Biosensors, 2021
Hypoxanthine (hpx) is an important molecule for both biochemistry research and biomedical applications. It is involved in several biological processes associated to energy and purine metabolism and has been proposed as a biomarker for a variety of ...
Marta Orts-Arroyo, Isabel Castro, José Martínez-Lillo   +2 more
doaj   +1 more source

Three Hypoxanthine Derivatives from the Marine Cyanobacterium Okeania hirsuta

Molbank
Three novel hypoxanthine derivatives (1–3) were obtained from the Okinawan cyanobacterium Okeania hirsuta. The structures of these compounds were elucidated mainly based on the spectroscopic data, including 1D and 2D NMR, as well as high-resolution mass ...
Ryoya Kawabe, Botao Zhang, Ryuichi Watanabe, Hajime Uchida, Masayuki Satake, Hiroshi Nagai   +5 more
doaj   +1 more source

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

Application of Liquid Chromatography Coupled to Mass Spectrometry for Direct Estimation of the Total Levels of Adenosine and Its Catabolites in Human Blood

Pharmaceuticals
Adenosine is a multifunctional nucleoside with several roles across various levels in organisms. Beyond its intracellular involvement in cellular metabolism, extracellular adenosine potently influences both physiological and pathological processes.
Jakub Šofranko, Peter Mitro, Zora Lazúrová, Martin Jozef Péč, Tomáš Bolek, Renata Péčová, Matúš Dohál, Matej Samoš, Radovan Murín   +8 more
doaj   +1 more source