Results 51 to 60 of about 86,184 (243)

Regulation of the G2/M Transition in Rodent Oocytes [PDF]

, 2010
Regulation of maturation in meiotically competent mammalian oocytes is a complex process involving the carefully coordinated exchange of signals between the somatic and germ cell compartments of the ovarian follicle via paracrine and cell–cell coupling ...
Downs, Stephen
core   +2 more sources

Hypoxanthine uptake by human erythrocytes [PDF]

FEBS Letters, 1979
It is well established that the uptake of hypoxan- thin, by human erythrocytes is mediated by its incorporation into IMP [ 11. The synthesis of this nucleotide is dependent on the intracellular availability of 5phosphoribosyl o-1-pyrophosphate (PRPP) and on the activity of hypoxanthine-guanine phospho- ribosyltransferase (HGPRT) [ 11.
GIACOMELLO, Alessandro, SALERNO, Costantino   +1 more
openaire   +3 more sources

Icariin Enhances the Enzymatic Activity of N‐acetylgalactosaminidase to Augment Akkermansia Abundance in Gut Microbiota for Improved PD‐1 Blockade Efficacy in Tumor Suppression

Advanced Science, EarlyView.
Icariin promoted the growth of Akk by enhancing the activity of N‐acetylgalactosaminidase (Amuc_0920), which enhanced mucin utilization and provided a favorable nutrient environment for bacterial growth. This icariin‐mediated enrichment of Akk further reshaped the tumor microenvironment and promoted CD8+ T cell infiltration, ultimately synergizing with
Shuangying Qiao, Liu Yang, Haibang Hao, Qiuxia Ding, Feng Ding, Zheng Chen, Jinfang Zhang, Yun He, Meng Li, Jun Xu, Chao Wang, Aiping Lu, Fangfei Li   +12 more
wiley   +1 more source

Fast Protein and Metabolites (Nucleotides and Nucleosides) Liquid Chromatography Technique and Chemical Sensor for the Assessment of Fish and Meat Freshness

Chemosensors, 2023
Fast protein and metabolite liquid chromatography (FPLMC) was introduced years ago to enable the easy separation of high-molecular compounds such as proteins from small molecules and the identification of the low-molecular substances.
Artur Kuznetsov, Aleksandr Frorip, Alar Sünter, Nensi Kasvand, Vadim Korsakov, Georgii Konoplev, Oksana Stepanova, Linda Rusalepp, Dea Anton, Tõnu Püssa, Mati Roasto, Liubov Abramova, Andrey Kozin, Lauri Toom, Soeren Hirsch, Nikolay Mukhin   +15 more
doaj   +1 more source

Upregulation of inducible NO synthase by exogenous adenosine in vascular smooth muscle cells activated by inflammatory stimuli in experimental diabetes [PDF]

, 2016
BACKGROUND: Adenosine has been shown to induce nitric oxide (NO) production via inducible NO synthase (iNOS) activation in vascular smooth muscle cells (VSMCs). Although this is interpreted as a beneficial vasodilating pathway in vaso-occlusive disorders,
Cignarella, Andrea, Gaion, ROSA MARIA, Malorgio, Francesca, Nassi, Alberto, Tedesco, Serena   +4 more
core   +2 more sources

Fosl2 Regulates FSH‐Dependent Follicle Maturation Through Feedback Amplification of FSH/FSHR Signaling

Advanced Science, EarlyView.
This study identifies a FOSL2‐driven positive feedback loop that amplifies FSH/FSHR signaling. During FSH‐dependent follicle maturation, FSH induces Fosl2 expression via the cAMP‐PKA‐CREB cascade. FOSL2 in turn binds the promoters of Fshr and estrogen‐biosynthesis genes to enhance their transcription, thereby increasing Fshr mRNA level and amplifying ...
Hongru Shi, Chaoli Chen, Zaohong Ran, Jianning Liao, Zian Wu, Xiaodong Wang, Yongheng Zhao, Wenkai Ke, Bowen Tan, Yun Liu, Youqiang Su, Wei Ren, Xiang Li, Changjiu He   +13 more
wiley   +1 more source

Evaluation of the Uricogenic Effect of Hypoxanthine and the Hypoxanthine‐Lowering Process of Shrimp (Metapenaeus ensis)

Food Frontiers
One of the main reasons for hyperuricemia is high purine intake and restricting the intake of high purine food is the main management for avoiding hyperuricemia.
Wanqian Sha, Lu xiao, Chunlin Tao, Chuanli Hou, Yanbo Wang, Huilin Liu, Jiaoyan Ren   +6 more
doaj   +1 more source

Integrative Analysis of Metabolomics and Transcriptomics Data Identifies Prognostic Biomarkers Associated With Oral Squamous Cell Carcinoma

Frontiers in Oncology, 2021
BackgroundOral squamous cell carcinoma (OSCC) is the most malignant neoplasm in oral cancer. There is growing evidence that its progression involves altered metabolism.
Lihua Zuo, Zhuo Chen, Lihuang Chen, Jian Kang, Yingying Shi, Liwei Liu, Shuhua Zhang, Qingquan Jia, Yi Huang, Zhi Sun   +9 more
doaj   +1 more source

Taxonomy and chemical characterization of new antibiotics produced by Saccharothrix SA198 isolated from a Saharan soil [PDF]

, 2013
Actinomycete strain SA198, isolated from a Saharan soil sample of Algeria, exhibited antimicrobial activity against Gram-positive and Gram-negative bacteria, and phytopathogenic and toxinogenic fungi.
A. Lebrihi, A. Zitouni, Andriole, Becker, Berdy, Betina, Buckingham, Bull, Bush, Bycroft, C. Bijani, D. Boubetra, F. Mathieu, Felsenstein, Felsenstein, Genilloud, Hayakawa, Hayakawa, Hosoe, Igarashi, Kalinovskaya, Kelly, Kim, Kimura, Kinochita, Labeda, Lamari, Lass-Flörl, Lazzarini, Lechevalier, Lechevalier, Liu, Locci, Merrouche, Minnikin, Murakami, N. Sabaou, Oki, Sabaou, Sanglier, Shirling, Singh, Stackebrandt, Suzuki, Takahashi, Takeuchi, Tamura, Thompson, Waksman, Wang, Zitouni, Zitouni, Zitouni   +52 more
core   +4 more sources

Metabolism‐Based Biomarkers for Rapid Phenotypic Antibiotic Susceptibility Testing

Advanced Science, EarlyView.
Metabolic differences emerging after antibiotic exposure provide rapid phenotypic signals of susceptibility and resistance. This review summarizes metabolic biomarkers for rapid phenotypic AST, associated with nutrient uptake, respiratory activity, metabolic reprogramming, and enzymatic function. ABSTRACT The accelerating global crisis of antimicrobial
Sha Yu, Bayinqiaoge, Xi Lu, Xin Wang, Rongfeng Wang, Yi Li, Shi‐Yang Tang, Chengchen Zhang   +7 more
wiley   +1 more source