Results 61 to 70 of about 64,168 (232)

The GPX3‐VCAM1 Axis Gates Pro‐Fibrotic Tubule Cell Fate in Hyperuricemic Nephropathy

Advanced Science, EarlyView.
Hyperuricemia induces NLRP3 inflammasome signaling activation and downregulation of GPX3 in proximal tubular epithelial cells, leading to oxidative stress–driven VCAM1 upregulation, emergence of pro‐fibrotic proximal tubule cells, macrophage recruitment, and renal fibrosis.
Yunfei Qi, Qiang Zhao, Yue Lve, Yaming Yuan, Tingting Zhou, Yue Yuan, Dexi Wu, Yifan Tang, Yan Liu, Zhigang Li, Chunping Jiang, Qiurong Ding   +11 more
wiley   +1 more source

Hypoxanthine N deuterated

, 2017
Inelastic Neutron Scattering spectrum of Hypoxanthine N deuterated, C₅H₂D₂N₄O, measured on the TOSCA ...
J. Tomkinson, ISIS Facility
core   +1 more source

Repair of Hypoxanthine in DNA Revealed by DNA Glycosylases and Endonucleases From Hyperthermophilic Archaea

Frontiers in Microbiology, 2021
Since hyperthermophilic Archaea (HA) thrive in high-temperature environments, which accelerate the rates of deamination of base in DNA, their genomic stability is facing a severe challenge.
Tan Lin, Likui Zhang, Likui Zhang, Mai Wu, Donghao Jiang, Zheng Li, Zhihui Yang   +6 more
doaj   +1 more source

FLAVIN-HYPOXANTHINE DINUCLEOTIDE

THE JOURNAL OF VITAMINOLOGY, 1957
1. FHD was synthesized from FAD by deamination with nitrous acid and the product was first isolated as barium salt. The yield and purity were, however, unsatisfactory by this method. Therefore, the product was extracted with cresol, followed by transfer in aqueous phase, and by subjecting to column chromatography, FHD was obtained in high purity in ...
openaire   +3 more sources

Effect of developmental changes on pharmacokinetics of drugs used in the treatment of infant acute lymphoblastic leukaemia—A comprehensive review

British Journal of Clinical Pharmacology, EarlyView.
While the event‐free survival (EFS) of children treated for acute lymphoblastic leukaemia (ALL) has improved greatly in the last decades, the EFS for patients diagnosed with ALL before the age of one is still under 50%. This outcome further decreases when infants have a rearrangement in the gene encoding histone‐lysine N‐methyltransferase 2A (KMT2A ...
Tirsa de Kluis, Leiah J. Brigitha, Lidwien M. Hanff, Alwin D. R. Huitema, Inge M. van der Sluis, Meta H. M. Diekstra   +5 more
wiley   +1 more source

Influence of physical, chemical and inducer treatments on menaquinone-7 biosynthesis by Bacillus subtilis MTCC 2756 [PDF]

Songklanakarin Journal of Science and Technology (SJST), 2015
Effects of physical and chemical treatment on nutrient mobility, their utilization for menaquinone-7 (MK-7) biosynthesis; growth of microbial cells has been investigated in the present research. Bacillus subtilis MTCC 2756 fermented medium was supplied
Alka Puri, Murteza Iqubal, Rasheeduz Zafar, Bibhu Prasad Panda   +3 more
doaj  

Metabolomic investigation of cisplatin‐induced acute kidney injury in paediatric cancer patients

British Journal of Clinical Pharmacology, EarlyView.
Aim Cisplatin causes acute kidney injury (AKI) in approximately 46% of paediatric cancer patients who receive it. Serum creatinine (SCr) is a poor biomarker of cisplatin nephrotoxicity, because there is a delay between cisplatin infusion and SCr elevation.
Yong Jin Lim, Amy Thachil, Kelly McMahon, Ross T. Tsuyuki, S. Rod Rassekh, Lesley G. Mitchell, Prasad Devarajan, Cherry Mammen, Bruce C. Carleton, Geoffrey D. E. Cuvelier, Victor A. Lewis, Colin J. D. Ross, Alexandra P. Zorzi, Sylvain Baruchel, Raveena Ramphal, Eric Bouffet, Mathieu Lemaire, Tom D. Blydt‐Hansen, Brad L. Urquhart, The Applying Biomarkers to Minimize Long‐Term Effects of Childhood/Adolescent Cancer Treatment (ABLE) Research Study Group, Tom Blydt‐Hansen, Bruce C. Carleton, Geoff D. E. Cuvelier, Sunil Desai, Prasad Devarajan, Conrad Fernandez, Adam Fleming, Paul Gibson, Caroline Laverdiere, Victor Lewis, Mary L. McBride, Bruno Michon, Shahrad Rod Rassekh, Colin J. D. Ross, Christine Sabapathy, Kirk R. Schultz, Michael Zappitelli, Alexandra Zorzi   +37 more
wiley   +1 more source

Partial hypoxanthine-guanine phosphoribosyl transferase deficiency without elevated urinary hypoxanthine excretion

, 2007
Partial hypoxanthine-guanine phosphoribosyl transferase (HGPRT) deficiency, also known as the Kelley-Seegmiller syndrome, can give rise to a wide range of neurological symptoms, and renal insufficiency.
van Spronsen, FJ, Niezen-Koning, K. E.; id_orcid, Pierik, LJWM, Reijngoud, D. J.; id_orcid, van Dael, CML, van Diggelen, O. P., Diggelen, Otto, van Spronsen, F. J., Niezen-Koning, KE, Pierik, L. J. W. M., Reijngoud, DJ, van Dael, C. M. L.   +11 more
core   +1 more source

Metabolism of hypoxanthine in wheat shoots [PDF]

, 2015
The incorporation of [14C] glycine and [8-l4C] hypoxanthine to some purine derivatives in overground parts of wheat seedlings was studied. It was found that adenylic acid could be synthesized from glycine and also from free hypoxanthine and in both ...
Hanna Rybicka
core   +1 more source

Unraveling the benefits of Bacillus subtilis DSM 29784 poultry probiotic through its secreted metabolites: an in vitro approach

Microbiology Spectrum
The probiotic Bacillus subtilis 29784 (Bs29784) sustains chicken’s intestinal health, enhancing animal resilience and performance through the production of the bioactive metabolites hypoxanthine (HPX), niacin (NIA), and pantothenate (PTH).
Nuria Vieco-Saiz, Damien P. Prévéraud, Eric Pinloche, Aurélien Morat, Pauline Govindin, Hervé M. Blottière, Elliot Matthieu, Estelle Devillard, Jessika Consuegra   +8 more
doaj   +1 more source