Results 81 to 90 of about 64,168 (232)

Na+ gradient-dependent transport of hypoxanthine by calf intestinal brush border membrane vesicles.

, 2003
The properties of hypoxanthine transport were investigated in purified brush border membrane vesicles isolated from calf proximal and distal jejunum.
Scharrer E, Theisinger A, Grenacher B
core   +1 more source

Transgenic selection and underlying mechanisms in apicomplexan parasites

The FEBS Journal, EarlyView.
Transgenic selection markers have driven genetic engineering in apicomplexans, enabling precise, iterative experiments. This review discusses mechanistic details of drug selection markers, strategies for marker recycling, and practical considerations for several clinically relevant parasites.
Swaroop Peddiraju, Rakhee Lohia, Nishith Gupta   +2 more
wiley   +1 more source

A NOVEL ENZYMATIC ASSAY METHOD FOR HYPOXANTHINE [PDF]

We developed a highly sensitive and rapid enzymatic assay for hypoxanthine with a Clark oxygen electrode as sensor. In the presence of sodium sulfite, oxidation of hypoxanthine by milk xanthine oxidase caused very rapid and increased oxygen consumption
Schmid, Rolf D., Kim, Jong Min, Suzuki, Masayasu   +2 more
core   +1 more source

Human APOBEC3G suppresses homologous recombination and LIG4‐independent end joining in DNA double‐strand break repair

The FEBS Journal, EarlyView.
Chromosomal DNA double‐strand breaks (DSBs) are repaired by homologous recombination and nonhomologous end joining (NHEJ). Recent work has additionally established theta‐mediated end‐joining (TMEJ) as a mechanism for DSB joining. Cells lacking NHEJ and TMEJ can repair DSBs in a homology‐dependent manner.
Shinta Saito, Miori Murayama, Usaki Arai, Sekifumi Akatsu, Ami Yamamoto, Misaki Kadoguchi, Noritaka Adachi   +6 more
wiley   +1 more source

Selective potentiation of lometrexol growth inhibition by dipyridamole through cell-specific inhibition of hypoxanthine salvage

, 1997
The novel antifolate lometrexol (5,10-dideazatetrahydrofolate) inhibits de novo purine biosynthesis, and co-incubation with hypoxanthine abolishes its cytotoxicity.
N.J., Curtin, Turner, G., R., Aherne
core   +4 more sources

Ueber Adenin und Hypoxanthin [PDF]

Berichte der deutschen chemischen Gesellschaft, 1890
n ...
openaire   +2 more sources

Biocatalytic synthesis of S‐adenosyl‐l‐methionine analogues for allosteric activation of cystathionine‐β‐synthase

The FEBS Journal, EarlyView.
Cystathionine‐β‐synthase (CBS) helps remove harmful homocysteine and supports the production of protective sulfur‐containing molecules. Using its natural activator, S‐adenosyl‐l‐methionine, as a template, we designed and tested 15 analogues. Three activated and stabilized the enzyme, including the newly identified S‐2‐amino‐adenosyl‐l‐methionine. These
Dalibor Nakládal, Žaneta Zajacová, Rick Oerlemans, Jana Havlikova, Gabriel Zorkócy, Lukáš Kerti, Katarína Sujová, Adrian Lengyel, Zoë van der Gun, Christina Yoseif, Adrianus Cornelis van der Graaf, Guido Krenning, Ján Kyselovič, Vladimír Frecer, Matthew R. Groves, Zdenko Levarski, André Heeres, Rob H. Henning, Leo E. Deelman   +18 more
wiley   +1 more source

Chelating Ligand Conformation Driving the Hypoxanthine Metal Binding Patterns

, 2016
The X-ray diffraction structural results of 23 ternary compounds, type MII(iminodiacetate-like)(hypoxanthine) [M = Co, Ni, Cu, or Zn], show that the iminodiacetate moiety conformation (mer-NO2 or fac-NO2) is able to drive the M-hypoxanthine binding ...
Alicia Domínguez-Martín (1838458), Juan Niclós-Gutiérrez (1838443), Dheerendra K. Patel (2150608), Duane Choquesillo-Lazarte (569029), Josefa María González-Pérez (2150611), M. Pilar Brandi-Blanco (2150605), Alfonso Castiñeiras (1838461)   +6 more
core   +1 more source

Simultaneous electrochemical determination of uric acid and hypoxanthine at a TiO2/graphene quantum dot-modified electrode

Beilstein Journal of Nanotechnology
A TiO2/graphene quantum dots composite (TiO2/GQDs) obtained by in situ synthesis of GQDs, derived from coffee grounds, and peroxo titanium complexes was used as electrode modifier in the simultaneous electrochemical determination of uric acid and ...
Vu Ngoc Hoang, Dang Thi Ngoc Hoa, Nguyen Quang Man, Le Vu Truong Son, Le Van Thanh Son, Vo Thang Nguyen, Le Thi Hong Phong, Ly Hoang Diem, Kieu Chan Ly, Ho Sy Thang, Dinh Quang Khieu   +10 more
doaj   +1 more source

Short-term metabolic adjustments in Plasmodium falciparum counter hypoxanthine deprivation at the expense of long-term viability

Malaria Journal, 2019
Background The malarial parasite Plasmodium falciparum is an auxotroph for purines, which are required for nucleic acid synthesis during the intra-erythrocytic developmental cycle (IDC) of the parasite.
Shivendra G. Tewari, Krithika Rajaram, Patric Schyman, Russell Swift, Jaques Reifman, Sean T. Prigge, Anders Wallqvist   +6 more
doaj   +1 more source