Results 101 to 110 of about 64,168 (232)

Predicted synthetic lethals involving DHFR with thymidine and hypoxanthine in the growth medium.

, 2022
(a) 4 genetic Minimal Cut Sets (gMCSs) and 2 nutrient-genetic Minimal Cut Sets (ngMCSs) involving DHFR. They were derived from Recon3D under the RPMI1640 growth medium plus thymidine and hypoxanthine; (b) Simplified network of metabolites and enzymes ...
Xabier Agirre (143264), Francisco J. Planes (6628901), Felipe Prosper (4721076), Luis V. Valcarcel (12239953), Edurne San José-Enériz (12239950), Iñigo Apaolaza (6628892)   +5 more
core   +1 more source

Plant‐Derived Probiotics From Fermented Foods: Current Evidence on Antiviral Mechanisms and Gut–Lung Axis Modulation

Food Frontiers, Volume 7, Issue 6, November 2026.
Plant‐derived probiotics from fermented foods exert anti‐respiratory virus effects via immune regulation, antiviral metabolites, and gut–lung axis, highlighting their advantages, key technologies, and application prospects. ABSTRACT Respiratory viral infections represent a major global public health threat, causing widespread morbidity, mortality, and ...
Yinghao Xing, Yaoyuan Hu, Yingying Ma, Peng Yao, Jingjing Jiang, Jiao Guo, Shuangmei Liu   +6 more
wiley   +1 more source

Persisting Region‐Specific Microglia Activation and Synaptic Imbalance During Remission in a DSS‐Induced Colitis Model

Glia, Volume 74, Issue 11, November 2026.
Relapsing colitis region‐specific microglial states beyond remission. Cortical microglia remain pro‐inflammatory and synapse‐disruptive, while hippocampal microglia shift toward a reparative program that maintains neuronal circuit stability. ABSTRACT Ulcerative colitis (UC) patients experience cycles of active gut inflammation and remission, with ...
Lorena Morton, Luis E. Villafuerte, Alejandra P. Garza, Nina Lindemann, Elisa Wider‐Eberspächer, Dunja Bruder, Ildiko R. Dunay   +6 more
wiley   +1 more source

Mosaic Mice with Teratocarcinoma-Derived Mutant Cells Deficient in Hypoxanthine Phosphoribosyltransferase

, 1977
MOSAIC MICE WITH TERATOCARCINOMA-DERIVED MUTANT CELLS DEFICIENT IN HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE Mosaic Mice with Teratocarcinoma-Derived Mutant Cells Deficient in Hypoxanthine Phosphoribosyltransferase (74) (-
Dewey, Michael J. David W. Martin Gail R. Martin Beatrice Mintz
core   +1 more source

Associations between muscle quality and whole-body vibration exercise-induced changes in plasma hypoxanthine following an oral glucose load in healthy male subjects

Endocrine Journal
Blood levels of hypoxanthine (HX) have been suggested as potential biomarkers associated with intramuscular metabolic dynamics in response to exercise.
Tomoyuki Hara, Yuya Fujishima, Hitoshi Nishizawa, Yusuke Kawachi, Takashi Nakamura, Seigo Akari, Yoshiyuki Ono, Hirotaka Watanabe, Taka-aki Sakaue, Yoshinari Obata, Hirofumi Nagao, Shiro Fukuda, Takashi Kanamoto, Mitsuyoshi Takahara, Naoto Katakami, Ken Nakata, Iichiro Shimomura   +16 more
doaj   +1 more source

XDH Inhibits the Progression of Colorectal Cancer via Regulating Ferritinophagy Signaling

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 11, November 2026.
XDH inhibits the progression of CRC via mediating ferritinophagy and ferroptosis. Therefore, XDH/ferritinophagy may be a potential target for CRC. ABSTRACT Xanthine dehydrogenase (XDH) is involved in the progression of various cancer. This study aimed to investigate its potential in colorectal cancer (CRC). Gene expression was determined using RT‐qPCR,
Huiying Zhang, Meimei Yan, Mengya Li, Junjiao Gu, Xintao Wang, Jin Ding, Suxia Luo   +6 more
wiley   +1 more source

Kinetic mechanism of Plasmodium falciparum hypoxanthine-guanine-xanthine phosphoribosyltransferase

, 2015
Plasmodium falciparum hypoxanthine-guanine-xanthine phosphoribosyltransferase (PfHGXPRT) exhibits a kinetic mechanism that differs from that of the human homolog.
Nagappa, Lakshmeesha K., Prahladarao, Vasudeva S., Balaram, Hemalatha, Roy, Sourav   +3 more
core   +1 more source

Brain network and energy imbalance in Parkinson’s disease: linking ATP reduction and α-synuclein pathology

Frontiers in Molecular Neuroscience
Parkinson’s disease (PD) involves the disruption of brain energy homeostasis. This encompasses broad-impact factors such as mitochondrial dysfunction, impaired glycolysis, and other metabolic disturbances, like disruptions in the pentose phosphate ...
Hirohisa Watanabe, Sayuri Shima, Kazuya Kawabata, Yasuaki Mizutani, Akihiro Ueda, Akihiro Ueda, Mizuki Ito, Mizuki Ito   +7 more
doaj   +1 more source

Hypoxanthine in stored blood [PDF]

Transfusion, 1991
R. Paroni, E. Bolzacchini, M. Samaja
openaire   +2 more sources

Hydroxamic Acids as HDAC Inhibitor Drug Leads for Malaria

Medicinal Research Reviews, Volume 46, Issue 6, Page 1477-1498, November 2026.
ABSTRACT Malaria is a global health threat, with an estimated 282 million cases and 610,000 malaria‐associated deaths reported in 2024. Most mortality is due to infection by Plasmodium falciparum parasites, with the highest burden occurring in Sub‐Saharan Africa.
Wisam A. Dawood, Jacinta R. Macdonald, Christian Anzenhofer, Tina S. Skinner‐Adams, Robert C. Reid, Thomas Kurz, David P. Fairlie, Katherine T. Andrews   +7 more
wiley   +1 more source