Results 101 to 110 of about 140,789 (198)

Targeting Hypoxia Inducible Factors-1α As a Novel Therapy in Fibrosis

Frontiers in Pharmacology, 2017
Fibrosis, characterized by increased extracellular matrix (ECM) deposition, and widespread vasculopathy, has the prominent trait of chronic hypoxia. Hypoxia inducible factors-1α (HIF-1α), a key transcriptional factor in response to this chronic hypoxia ...
Anji Xiong, Yi Liu
doaj   +1 more source

Transcriptomic analysis of the hypoxia-inducible factor 1α impact on the gene expression profile of chicken fibroblasts under hypoxia

Poultry Science
: Hypoxia-inducible factor 1 (HIF-1) is a transcriptional regulator that mediates cellular adaptive responses to hypoxia. Hypoxia-inducible factor 1α (HIF-1α) is involved in the development of ascites syndrome (AS) in broiler chickens.
Aikebaier Reheman, Qijun Wu, Jianing Xu, Jiang He, Meng Qi, Kai Li, Gang Cao, Xinwei Feng   +7 more
doaj   +1 more source

Hypoxia Inducible Factor-1α (HIF-1α): A Biomarker for Detection of Malignant Transformation in Oral Submucous Fibrosis

Pakistan Journal of Medicine and Dentistry
Oral submucous fibrosis (OSMF) is a premalignant condition, which involves the oral cavity as well as pharynx and upper third of the esophagus. It is a predominant disease of South and South-East Asian population.
Kanwal Iqbal , Mervyn Hosein, Saima Butt   +2 more
doaj   +1 more source

HER2 (neu) Signaling Increases the Rate of Hypoxia-Inducible Factor 1α (HIF-1α) Synthesis: Novel Mechanism for HIF-1-Mediated Vascular Endothelial Growth Factor Expression

Molecular and Cellular Biology, 2001
E. Laughner, P. Taghavi, K. Chiles, P. Mahon, G. Semenza   +4 more
semanticscholar   +1 more source

Regulation of hypoxia-inducible factor 1α is mediated by an O2-dependent degradation domain via the ubiquitin-proteasome pathway

, 1998
Lei Huang, J. Gu, M. Schau, H. Bunn
semanticscholar   +1 more source

Differential Roles of Hypoxia-Inducible Factor 1α (HIF-1α) and HIF-2α in Hypoxic Gene Regulation

Molecular and Cellular Biology, 2003
Cheng-Jun Hu, Liyi Wang, Lewis A. Chodosh, B. Keith, M. Simon   +4 more
semanticscholar   +1 more source

Regulation of Hypoxia-Inducible Factor 1α Expression and Function by the Mammalian Target of Rapamycin

Molecular and Cellular Biology, 2002
Christine C. Hudson, Mei Liu, G. Chiang, D. Otterness, Dawn C. Loomis, F. Kaper, A. Giaccia, R. Abraham   +7 more
semanticscholar   +1 more source

Regulation of Cancer-Associated miRNAs Expression under Hypoxic Conditions

Analytical Cellular Pathology
Solid tumors frequently experience hypoxia or low O2 levels. In these conditions, hypoxia-inducible factor 1 alpha (HIF-1α) is activated and acts as a transcription factor that regulates cancer cell adaptation to O2 and nutrient deprivation.
Jesús Valencia-Cervantes, Martha Patricia Sierra-Vargas   +1 more
doaj   +1 more source

Hypoxia Inducible Factor‐1α Potentiates Jagged 1‐Mediated Angiogenesis by Mesenchymal Stem Cell‐Derived Exosomes

Stem Cells, 2017
H. González-King, Nahuel A. García, I. Ontoria-Oviedo, María Ciria, J. Montero, P. Sepúlveda   +5 more
semanticscholar   +1 more source

Dynamic regulation of hypoxia-inducible factor-1α activity is essential for normal B cell development

Nature Immunology, 2020
N. Burrows, Rachael J. M. Bashford-Rogers, Vijesh J. Bhute, Ana Peñalver, J. Ferdinand, B. Stewart, Joscelin E. G. Smith, Mukta Deobagkar-Lele, Girolamo Giudice, T. Connor, A. Inaba, L. Bergamaschi, Sam Smith, Maxine G. B. Tran, E. Petsalaki, P. Lyons, M. Espéli, B. Huntly, Kenneth G. C. Smith, R. Cornall, M. Clatworthy, P. Maxwell   +21 more
semanticscholar   +1 more source