Results 261 to 270 of about 180,302 (314)

Hypoxia-inducible factor 1α is required to establish the larval glycolytic program in Drosophila melanogaster. [PDF]

Mol Metab
Heidarian Y, Fasteen TD, Mungcal L, Buddika K, Mahmoudzadeh NH, Nemkov T, D'Alessandro A, Tennessen JM.   +7 more
europepmc   +1 more source

Laparoscopic Delivery of a MnO2‐P‐ICG Patch for Photodynamic Therapy and NK Cell‐Driven Immunotherapy in Hepatocellular Carcinoma

Advanced Science, EarlyView.
This study proposes a flexible MnO2‐P‐ICG nanofiber patch for laparoscopic treatment of liver tumors. The patch alleviates tumor hypoxia and induces photodynamic therapy (PDT) triggered immunogenic cell death, thereby activating the cGAS‐STING pathway and, in synergy with pachymaran, promoting NK cell–mediated innate immunity. This synergistic strategy
Jie Lin, Haoqi Pan, Ke Wu, Junjie Nan, Jinyao Dai, Yushun Chang, Hao Shen, Qingxuan Ye, Haowen Lu, Yuxuan Shen, Boqiang Liu, Ming Wu, Jicheng Yu, Xiujun Cai, Dong Cen   +14 more
wiley   +1 more source

Ultrasound Activated Piezoelectric Dural Patches to Drive Endogenous Neural Stem Cell–Mediated Repair Traumatic Brain Injury

Advanced Science, EarlyView.
This study presents a wireless, non‐invasive strategy for neural repair by developing a biodegradable piezoelectric dural patch that, under transcranial ultrasound, generates localized electrical fields to drive endogenous neural stem cells toward neuronal differentiation and functional integration.
Pengbo Zhou, Qingyuan Wu, Yang Wu, Runzhe Huang, Wei Li, Hanjie Niu, Hongtao Sun, Huiyu Liu   +7 more
wiley   +1 more source

Intestine epithelial-specific hypoxia-inducible factor-1α overexpression ameliorates western diet-induced MASLD. [PDF]

Hepatol Commun
Xu M, Taylor MS, Hill BG, Li X, Rouchka EC, McClain CJ, Song M.   +6 more
europepmc   +1 more source

A Dynamic 3D Human Liver Sinusoid Model for Mechanistic Interrogation of Fontan‐Associated Liver Disease

Advanced Science, EarlyView.
This study presents a perfusable 3D bioengineered liver sinusoid platform that integrates biofabrication, 3D cell culture, controlled hemodynamics, and multiparametric characterization to model Fontan‐associated liver disease. By decoupling pressure and hypoxia effects, the system reveals early mechanobiological and profibrotic responses under ...
Sarah Rezapourdamanab, Mehdi Salar Amoli, Tanmay Mukherjee, Maryam Bagheri, Boeun Hwang, Linqi Jin, Yamini Singh, Sophia Norton, Ashay Vishwas Bongirwar, Shweta Karnik, Lakshmi Prasad Dasi, Reza Avazmohammadi, Rene Romero, Holly D. Bauser‐Heaton, Vahid Serpooshan   +14 more
wiley   +1 more source

Central role of hypoxia-inducible factor-1α in metabolic reprogramming of cancer cells: A review. [PDF]

Medicine (Baltimore)
Zhu B, Cheng L, Huang B, Liu R, Ren B.
europepmc   +1 more source

Seedless One‐Pot Synthesis of Colloidal InAs Quantum Dots Enabling a High‐Accuracy Photoplethysmography Oximeter

Advanced Science, EarlyView.
A real‐time, non‐contact photoplethysmography (PPG) system based on InAs colloidal quantum dots (CQDs) synthesized via a seedless injection synthesis is demonstrated. The measured oxygen saturation shows considerable agreement with commercial PPG devices.
Beom Kwan Kim, Seungin Jee, Yongnam Ahn, In‐Suh Lee, Dongeon Kim, Seongchong Park, Yujin Jung, In‐Ho Bae, Se‐Woong Baek   +8 more
wiley   +1 more source

Hypoxia-inducible factor-1α in myocardial infarction. [PDF]

World J Cardiol
Škrlec I, Kolomeichuk SN.
europepmc   +1 more source

Self‐Amplifying Redox Cycle Triggers Ferroptosis/Cuproptosis Synergy for Enhanced Bacterial Eradication

Advanced Science, EarlyView.
This study designs a targeted nanocomposite (ct@HMCF‐Dex) that responds to acidic infection microenvironments, releasing components which amplify oxidative stress. It disrupts bacterial redox balance, chelates metals to sustain lipid peroxidation, and synergistically induces cuproptosis/ferroptosis‐like death.
Zehui Xiao, Shaolong Qiu, Jiangli Cao, Jifeng Liu, Zhiyong Song, Ting Du, Xinjun Du   +6 more
wiley   +1 more source

Correction to "TFRC in Cardiomyocytes Promotes Macrophage Infiltration and Activation During the Process of Heart Failure Through Regulating Ccl2 Expression Mediated by Hypoxia Inducible Factor-1Α". [PDF]

Immun Inflamm Dis
europepmc   +1 more source