Results 91 to 100 of about 32,906,174 (307)
Antioxidants, 2017 The importance of the tumor microenvironment for cancer progression and therapeutic resistance is an emerging focus of cancer biology. Hypoxia, or low oxygen, is a hallmark of solid tumors that promotes metastasis and represents a significant obstacle to
Rachel K. Toth, Noel A. Warfel
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Design and Synthesis of Small-molecule Inhibitors of the Hypoxia Inducible Factor-1 as Anticancer Therapeutics [PDF]
, 2016 Throughout history, cancer has been severely plaguing mankind; the search for a A cure for cancer has long been sought by scientists and still poses as one of the greatest challenges scientists have yet to overcome.
De Los Santos, Zeus Allen O.
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Molecular Oncology, EarlyView.In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico +5 more
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Hypoxia-Inducible Factor 1 Protects Hypoxic Astrocytes against Glutamate Toxicity
ASN Neuro, 2012 Stroke is a major neurological disorder characterized by an increase in the Glu (glutamate) concentration resulting in excitotoxicity and eventually cellular damage and death in the brain. HIF-1 (hypoxia-inducible factor-1), a transcription factor, plays
Yomna Badawi +2 more
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Inhibiting Hypoxia-Inducible Factor 1 for Cancer Therapy [PDF]
Molecular Cancer Research, 2006 AbstractHypoxia has long been recognized as a common feature of solid tumors and a negative prognostic factor for response to treatment and survival of cancer patients. The discovery of hypoxia-inducible factor 1 (HIF-1), a molecular determinant of the response of mammalian cells to hypoxia, has led to the identification of a “molecular target” of ...
openaire +2 more sources
Deguelin attenuates reperfusion injury and improves outcome after orthotopic lung transplantation in the rat [PDF]
, 2012 The main goal of adequate organ preservation is to avoid further cellular metabolism during the phase of ischemia. However, modern preservation solutions do rarely achieve this target.
Paulus, Patrick +26 more
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FEBS Open Bio, EarlyView.UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová +2 more
wiley +1 more source
Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum, 2013 Background and Objectives: Cadmium is one of the most important biological contaminants that its intake in pregnancy causes disease and malformation s in the mother and baby.
Shadmehr Mirdar +3 more
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Radiolabeled Probes Targeting Hypoxia-Inducible Factor-1-Active Tumor Microenvironments
The Scientific World Journal, 2014 Because tumor cells grow rapidly and randomly, hypoxic regions arise from the lack of oxygen supply in solid tumors. Hypoxic regions in tumors are known to be resistant to chemotherapy and radiotherapy.
Masashi Ueda, Hideo Saji
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Hypoxia, Hypoxia-Inducible Factor-1α, and Innate Antileishmanial Immune Responses
Frontiers in Immunology, 2018 Low oxygen environments and accumulation of hypoxia-inducible factors (HIFs) are features of infected and inflamed tissues. Here, we summarize our current knowledge on oxygen levels found in Leishmania-infected tissues and discuss which mechanisms ...
Valentin Schatz +3 more
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