Results 181 to 190 of about 32,906,174 (307)

A Novel IDO1/NE Dual Inhibitor, IMM‐H018 Prevents the Primary and Secondary Sepsis and Ameliorates the Kidney Injury Through Inhibiting the Cytokine Storm and Microthrombosis, and Reversing Immunosuppression

Advanced Science, EarlyView.
IMM‐H018, a dual IDO1/NE inhibitor, demonstrates potent therapeutic efficacy in sepsis by simultaneously targeting excessive inflammation and immune dysfunction. It prevents both primary and secondary sepsis through anti‐inflammatory, immune‐restoring, and renoprotective mechanisms, reducing organ damage, improving immune homeostasis, preserving kidney
Yi Zhou, Xiaodi Zhao, Xiaochen Pan, Zhiling Ma, Huaqing Cui, Hui Wen, Peng Wang, Xiufeng Liao, Kejie Qin, Yuchen Wang, Li Sheng, Sen Zhang   +11 more
wiley   +1 more source

Hypoxia inducible factor 1 subunit alpha mediates autophagy disorder of oral lichen planus by regulating lysosomal pathway. [PDF]

Front Immunol
Li X, Han C, Yao Y, Shi Y, Chen B, Xiao Y, Bai G.   +6 more
europepmc   +1 more source

TRAF6 Lactylation in Glycolytic Macrophages Drives NF‐κB Signaling and M1 Polarization During Orthodontic Tooth Movement

Advanced Science, EarlyView.
Schematic diagram showing compressive stress triggers glycolytic reprogramming and lactate accumulation in macrophages. Lactate mediates TRAF6 lactylation at K171/K180 dual sites, which enhances its K63‐linked ubiquitination to activate the NF‑κB pathway and promote M1 polarization. This cascade drives orthodontic tooth movement (OTM) and alveolar bone
Xinyi He, Guodong Zhao, Yun Hu, Wenya Bai, Hao Tan, Shuai Yuan, Sihan Yang, Ye Zhu, Xiaohui Xu, Leilei Zheng   +9 more
wiley   +1 more source

JAK2V617F reprograms Hypoxia Inducible Factor-1 to induce a non-canonical hypoxia regulon in myeloproliferative neoplasms. [PDF]

Leukemia
Kealy D, Ellerington R, Bansal S, Medeiros JJF, Hawley CA, Zeng AGX, Lukaszonek J, West KA, Sinha AD, Caalim G, Gawne RT, Pope J, Ferreira BL, Blacknell NM, Drylie B, Chatzigerou J, Khoo HM, Wilkinson AC, Fielding AK, Wang G, Psaila B, Kent DG, Hitchcock IS, Holding AN, Mason AS, Gupta V, Dick JE, Bridge KS.   +27 more
europepmc   +1 more source

Microenvironment‐Responsive Nanomedicine Enables Vertical Modulation of Mitochondrial Pathological Networks in Myocardial Ischemia–Reperfusion Injury

Advanced Science, EarlyView.
A mitochondria‐targeted, microenvironment‐responsive nanoplatform enables pH/ROS‐triggered co‐delivery of berberine and isoliensinine to orchestrate ROS scavenging, inflammation suppression, and apoptosis inhibition. This vertical modulation of mitochondrial pathological networks preserves mitochondrial function and effectively mitigates myocardial ...
Jue Wang, Jia Zhou, Wenqin Yuan, Tianjiao Zhao, Yunying Huang, Yingci Xia, Yuting Lin, Fei Li, Qiong Huang, Chong Liu, Kelong Ai, Qun Qin   +11 more
wiley   +1 more source

Pharmacological stabilization of hypoxia-inducible factor 1-α dampens the interferon response and promotes glycolysis in Aicardi-Goutières syndrome. [PDF]

Nat Commun
Batignes M, Luka M, Jagtap S, de Cevins C, Nemazanyy I, Leib J, Fali T, Pierga A, Zarhrate M, García-Paredes V, Carbone F, Pérot BP, Neven B, Bader-Meunier B, Quartier P, Hully M, Belot A, Lepelley A, Frémond ML, Fischer A, Ménager MM.   +20 more
europepmc   +1 more source

Single‐cell Transcriptome Profiling Reveals Gene Regulatory Networks and Key Genes in the Root Epidermis and Cortical Cells Associated with Early Nodulation in Glycine Max

Advanced Science, EarlyView.
Single‐cell transcriptomics of soybean roots soon after rhizobial inoculation reveals epidermal and cortical cell‐specific programs and gene‐regulatory networks acting in symbiosis establishment. We identify an ethylene‐driven regulatory circuit involving WRKY6.3/6.4 transcription factors targeting select Nod19 genes that promotes infection‐thread ...
Yongbin Zhuang, Yu Geng, Xinyu Guo, Chen Wang, Yongjing Sun, Luqi Liu, Li Liu, QianQian Gao, XinFang Zhu, Hongxiang Cao, Gengshuo Zhang, Yunxia Liu, Guobin Zhang, Baoyin Chen, Jinfei Zhang, Xin Hou, Xiaoming Li, Dajian Zhang   +17 more
wiley   +1 more source

Mammalian oxygen sensing and hypoxia inducible factor-1

The International Journal of Biochemistry & Cell Biology, 1997
Wood, S, Ratcliffe, P
openaire   +2 more sources

Histone H3K18 Lactylation Promotes the Malignant Progression of Wilms Tumor via a PSRC1/AKT/HIF‐1α Positive Feedback Loop

Advanced Science, EarlyView.
In nephroblastoma, aberrant glycolysis drives lactate accumulation, which elevates histone H3K18 lactylation via p300. Lactylation of the PSRC1 promoter activates its transcription. PSRC1 competitively binds AKT, relieving PTEN‐mediated inhibition and triggering AKT/mTOR/HIF‐1α signaling.
Yanping Wang, Hongjie Gao, Bifei Zhang, Xuetian Li, Ding Li, Aihua Cao, Fengyin Sun   +6 more
wiley   +1 more source

Hydroxychloroquine Attenuates Atherosclerosis in Apolipoprotein E Knockout Mice: Role of Endothelial Nitric Oxide Synthase and Hypoxia-Inducible Factor 1-Alpha. [PDF]

Cardiol Res
Poulakida E, Ioannou M, Sagris D, Polychronopoulou E, Makaritsis PK, Georgopoulos S, Xanthopoulos A, Kouvaras E, Kapatou K, Asprodini E, Nanas IA, Konstantinidis A, Koukoulis GΚ, Dalekos GΝ, Makaritsis KP.   +14 more
europepmc   +1 more source