Results 21 to 30 of about 136,766 (265)
HIF-α Prolyl Hydroxylase Inhibitors and Their Implications for Biomedicine: A Comprehensive Review
Biomedicines, 2021 Oxygen is essential for the maintenance of the body. Living organisms have evolved systems to secure an oxygen environment to be proper. Hypoxia-inducible factor (HIF) plays an essential role in this process; it is a transcription factor that mediates ...
Kiichi Hirota
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Hypoxia-inducible factor-1 in tumour angiogenesis
World Journal of Gastroenterology, 2004 Hypoxia-inducible factor-1 (HIF-1), composed of HIF-alpha and HIF-beta subunits, is a heterodimeric transcriptional activator. In response to hypoxia, stimulation of growth factors, and activation of oncogenes as well as carcinogens, HIF-1alpha is overexpressed and/or activated and targets those genes which are required for angiogenesis, metabolic ...
Yong-Hong, Shi, Wei-Gang, Fang
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Haematologica, 2010 Background Multiple myeloma is an incurable malignancy of bone marrow plasma cells. Progression of multiple myeloma is accompanied by an increase in bone marrow angiogenesis.
Sally K. Martin +8 more
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Contribution of hypoxia inducible factor-1 during viral infections
Virulence, 2020 Hypoxia-inducible factor 1 (HIF-1) is a transcription factor that plays critical roles during the cellular response to hypoxia. Under normoxic conditions, its function is tightly regulated by the degradation of its alpha subunit (HIF-1α), which impairs ...
Antonia Reyes +5 more
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Activation of Hypoxia-Inducible Factor-1 in Bacillary Angiomatosis [PDF]
Circulation, 2005 Background— Bartonella species are the only known bacterial pathogens causing vasculoproliferative disorders in humans (bacillary angiomatosis [BA]). Cellular and bacterial pathogenetic mechanisms underlying the induction of BA are largely unknown.
Volkhard A J, Kempf +13 more
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Hypoxia‐inducible factor 1 and cancer pathogenesis [PDF]
IUBMB Life, 2008 AbstractHypoxia‐inducible factor 1 (HIF‐1) is a transcriptional activator that mediates adaptive responses to hypoxia. HIF‐1 activity is increased in the majority of human cancers as a result of genetic alterations and intratumoral hypoxia. HIF‐1 activates the transcription of genes that increase O2 availability by stimulating angiogenesis or that ...
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Synthesis of Neolamellarin A, an Inhibitor of Hypoxia-Inducible Factor-1 [PDF]
Natural Product Communications, 2009 Neolamellarin A, a metabolite isolated from the sponge Dendrilla nigra, was found to inhibit hypoxia-inducible factor-1 (HIF-1) activation by 26% at 10 μM concentration and inhibition of HIF-1 has become a major antitumor molecular target. Herein the first synthesis of neolamellarin A is described.
Khaled M, Arafeh, Nisar, Ullah
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Molecules, 2018 Induction of a series of anti-hypoxic proteins protects cells during exposure to hypoxic conditions. Hypoxia-inducible factor-α (HIF-α) is a major transcription factor that orchestrates this protective effect.
Shin-ichi Kawaguchi +11 more
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Tumor Biology, 2017 Many studies have analyzed the relationship between hypoxia inducible factor 1 alpha expression and its relation to differentiation, lymph node metastasis, and other clinicopathological variables of esophageal carcinoma, but the results are still ...
Shao Wu Jing, Jun Wang, Qing Xu
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Advanced Medical Journal, 2023 Background and objectives: Papillary thyroid carcinoma is one of the most common cancers of human, monocarbox- ylate transporter 1 and hypoxia inducible factor 1 alpha expressions in many tumors have recently being targets for treatment, HIF-1a has been
Hadeel Adnan Yasseen +1 more
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