Results 181 to 190 of about 56,007 (232)

Intermittent hypoxic stimulation promotes efficient expression of Hypoxia-inducible factor-1α and exerts a chondroprotective effect in an animal osteoarthritis model. [PDF]

PLoS One
Cha R, Nakagawa S, Arai Y, Inoue A, Okubo N, Fujii Y, Kaihara K, Nakamura K, Kishida T, Mazda O, Takahashi K.   +10 more
europepmc   +1 more source

Targeting the Enhanced Sensitivity of Radiotherapy in Cancer: Mechanisms, Applications, and Challenges

MedComm, Volume 6, Issue 6, June 2025.
In this review, we first introduced the current application scenarios for radiotherapy in tumor treatment, the molecular mechanisms underlying anticancer effects of radiotherapy in treatment of cancer, and the side‐effects of radiotherapy. Second, we pay attention to discuss the main types of radiosensitizers and their latest applications and ...
Yuanyuan Zhao, Fangqin Tan, Jiajia Zhao, Shuchang Zhou, Yao Luo, Chen Gong   +5 more
wiley   +1 more source

Carbonic anhydrase IX downregulation linked to disruption of HIF-1, NFκB and STAT3 pathways as a new mechanism of ibuprofen anti-cancer effect. [PDF]

PLoS One
Grossmannova K, Belvoncikova P, Puzderova B, Simko V, Csaderova L, Pastorek J, Barathova M.   +6 more
europepmc   +1 more source

Lactylation: From Homeostasis to Pathological Implications and Therapeutic Strategies

MedComm, Volume 6, Issue 6, June 2025.
Lactylation, a novel post‐translational modification derived from lactate metabolism, plays a critical role in cellular homeostasis and disease pathogenesis. Under physiological conditions, lactylation regulates gene expression, immune responses, and metabolic adaptation. However, dysregulated lactylation is implicated in various pathological processes,
Xi Chen, Yixiao Yuan, Fan Zhou, Lihua Li, Jun Pu, Yong Zeng, Xiulin Jiang   +6 more
wiley   +1 more source

Acute Severe Hypoxia Decreases Mitochondrial Chain Complex II Respiration in Human Peripheral Blood Mononuclear Cells. [PDF]

Int J Mol Sci
Riou M, Charles AL, Enache I, Evrard C, Pistea C, Giannini M, Charloux A, Geny B.   +7 more
europepmc   +1 more source

Role and Mechanisms of the mTOR Signalling Pathway in the Synthesis of Milk Components

Modern Agriculture, Volume 3, Issue 1, June 2025.
The regulatory network system of mTOR regulates lactose, milk fat, and milk protein. Milk is urgently needed for the strong development of the dairy industry to meet the growing demand and ensure that the nutritional needs of the world's population are met.
RongNuo Li, YiNing Zheng, HuiJun Geng, Lu Deng   +3 more
wiley   +1 more source

Exosomes in Skin Flap Survival: Unlocking Their Role in Angiogenesis and Tissue Regeneration. [PDF]

Biomedicines
Chen BD, Zhao Y, Wu JL, Zhu ZG, Yang XD, Fang RP, Wu CS, Zheng W, Xu CA, Xu K, Ji X.   +10 more
europepmc   +1 more source

Characteristic, Regulation and Targeting Strategies of Cancer Stem Cells and Their Niche in Digestive System Tumors

MedComm – Oncology, Volume 4, Issue 2, June 2025.
Cancer stem cells, characterized by self‐renewal, differentiation, heterogeneity, plasticity and tumorigenicity, are regulated by intrinsic factors such as signaling pathways, transcription factors, metabolism and noncoding RNAs, as well as environmental cells (including tumor cells, immune cells and stromal cells), environmental factors and distant ...
Zhenzhen Chen, Huanle Qi, Yapeng Xue, Yaqi Zhang, Zhuo Zhang, Shun Xu, Shixin Liao, Xiaoyu Zeng, Jiayi Wu, Xinrui Lv, Qiankun He, Pingping Zhu   +11 more
wiley   +1 more source

The mediator subunit complex protein MED15 promotes lipid deposition and cancer progression during hypoxia. [PDF]

J Biol Chem
Zhang B, Zhu Y, Tang Y, Liu L, Liu Y, Li Y, Yu W, Lu L.   +7 more
europepmc   +1 more source