Results 201 to 210 of about 65,547 (283)

HIF-1α siRNA Enhances the Efficacy of Erlotinib in Non-small Cell Lung Cancer: A Novel Strategy to Reverse Hypoxia-Induced Drug Resistance. [PDF]

Drugs R D
Jiang H, Cai S, Zhang X, Chen S, Yue C, Yin W, Hu Y.   +6 more
europepmc   +1 more source

Proteolytic remodelling of the extracellular matrix by pericytes

The FEBS Journal, EarlyView.
Pericytes are specialised perivascular cells intimately connected with endothelial cells and essential for the maintenance of vascular beds. They contribute to the formation and remodelling of the extracellular matrix by actively secreting proteases and protease inhibitors.
Tina Burkhard, Ella Milne, Kate Qian, Paola Campagnolo, Salvatore Santamaria   +4 more
wiley   +1 more source

HIF1α Attenuated the Lung Ischemia-Reperfusion Injury by Activating the miR-485/Notch1 Signalling. [PDF]

J Cell Mol Med
Dai S, Wan X, Xia L, Xu L, Xie C, Wang G, Tang J.   +6 more
europepmc   +1 more source

Molecular Signatures of Peripheral and Central Dental Pulp Subpopulations in Response to Streptococcus mutans: A Bulk RNA‐Seq Analysis

International Endodontic Journal, EarlyView.
ABSTRACT Aim The dental pulp is an immunologically active tissue that responds dynamically to cariogenic challenge. Peripheral pulp cells adjacent to dentine encounter bacterial stimuli earlier than cells located in the central pulp. To investigate signalling and immune interactions, this study profiled the transcriptomes of dentine‐adherent cells ...
Sandra Pohl, Maximilian L. Huber, Tobias Akamp, Andreas Rosendahl, Melanie Linnebank, Lea Schreiber, Claudia Gebhard, Nicholas Strieder, Michael Rehli, Wolfgang Buchalla, Matthias Widbiller   +10 more
wiley   +1 more source

Oncometabolites and Hypoxia-Regulated Exosomes Shape HIF-Driven Macrophage Programs Across Type 2 Diabetes, Atherosclerosis, and Cancer. [PDF]

Int J Mol Sci
Nowinka A, Krystek G, Gontarek Z, Góralczyk M, Waligórska A, Walenciak M, Formanowicz D.   +6 more
europepmc   +1 more source

Transcriptomic profiling of gill biopsies to define predictive markers for seawater survival in farmed Atlantic salmon

Journal of Fish Biology, EarlyView.
Abstract Wild Atlantic salmon migrate to sea following completion of a developmental process known as parr‐smolt transformation (PST), which establishes a seawater (SW) tolerant phenotype. Effective imitation of this aspect of anadromous life history is a crucial aspect of commercial salmon production, with current industry practice being marred by ...
Lars Grønvold, Mattis J. van Dalum, Anja Striberny, Domniki Manousi, Trine Ytrestøyl, Turid Mørkøre, Solomon Boison, Bjarne Gjerde, Even Jørgensen, Simen R. Sandve, David G. Hazlerigg   +10 more
wiley   +1 more source

Trophoblast adaptation to hypoxia: balance and dysfunction. [PDF]

Cell Commun Signal
Li Q, Wei X, Zhang Y, Zeng W, Lin Y.
europepmc   +1 more source

Genetic Susceptibility to Periodontitis

Journal of Periodontal Research, EarlyView.
Aim: The aim of this narrative review was to identify genes carrying risk alleles associated with an increased risk of periodontitis and to place them in a biological context. Methods: The literature was reviewed based on predefined criteria. Results: The identified genes largely fall into functions linking immune response with tissue repair. The genes
Gesa M. Richter, Arne S. Schaefer
wiley   +1 more source

Understanding the Impact of Hypoxia on Pulmonary Artery Endothelial Cells in Chronic Thromboembolic Pulmonary Hypertension Patients. [PDF]

Int J Mol Sci
Roger Y, Sardiné-Rama A, Bosacoma A, Gómez I, Fernández-Hernández R, Jimenez-Trinidad FR, Rodríguez C, Bonjoch C, Almendros I, Marhuenda E, Urrutia AA, Peracaula M, Castellà M, Blanco I, Ramírez A, Peinado VI, Barberà JA, Tura-Ceide O.   +17 more
europepmc   +1 more source

Systemic, Lifestyle and Environmental Modifying Factors in the Pathogenesis of Periodontitis

Journal of Periodontal Research, EarlyView.
A variety of impacting factors in the pathogenesis of periodontitis exist, including systemic, lifestyle, and environmental factors. This review highlights the manifold mechanistic aspects of the link between the pathogenesis of periodontitis, addressing these numerous factors to supplement the long‐standing knowledge of the progression of the disease.
Groeger Sabine Elisabeth, Zhou Yuxi, Yong Jiawen, Wang Lei, Ruf Sabine, Meyle Joerg   +5 more
wiley   +1 more source