Results 221 to 230 of about 132,175 (264)
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The Utility of Hypoxia Inducible Factor 1 Subunit Alpha (HIF1A) in the Differential Diagnosis of Pancreatic Cystic Neoplasms

International Journal of Surgical Pathology
Objective This study aims to evaluate the diagnostic utility of hypoxia inducible factor 1 subunit alpha (HIF1A) and carbonic anhydrase 9 (CA9) expression in differentiating between the 3 main types of pancreatic cystic neoplasms (PCNs): serous cystic ...
Cuiping Li   +5 more
semanticscholar   +2 more sources

Abstract 4853: Knockout of hypoxia inducible factor 1 subunit alpha (HIF1a) augments the antitumor activity of EGFR CAR-NK cells

Cancer Research
Chimeric antigen receptor T-cell (CAR-T) therapies have gained remarkable success with durable remissions in hematologic malignancies. However, the potential adverse effects, including cytokine release syndrome (CRS), graft-versus-host disease (GVHD ...
Fanxiang Gao   +6 more
semanticscholar   +2 more sources

Apatinib Inhibits Angiogenesis in Intrahepatic Cholangiocarcinoma by Regulating the Vascular Endothelial Growth Factor Receptor-2/Signal Transducer and Activator of Transcription Factor 3/Hypoxia Inducible Factor 1 Subunit Alpha Signaling Axis

Pharmacology, 2021
<b><i>Introduction:</i></b> Intrahepatic cholangiocarcinoma (ICC), which is difficult to diagnose and is usually fatal due to its late clinical presentation and a lack of effective treatment, has risen over the past decades but without much improvement in prognosis. <b><i>Objective:</i></b> The study aimed
Manping Huang   +6 more
semanticscholar   +3 more sources

Activation of the Hypoxia Inducible Factor 1α Subunit Pathway in Steatotic Liver Contributes to Formation of Cholesterol Gallstones [PDF]

open access: yesGastroenterology, 2017
Hypoxia-inducible factor 1α subunit (HIF1A) is a transcription factor that controls the cellular response to hypoxia and is activated in hepatocytes of patients with nonalcoholic fatty liver disease (NAFLD). NAFLD increases the risk for cholesterol gallstone disease by unclear mechanisms.
Yoshiyuki Ueno   +2 more
exaly   +3 more sources

Nimodipine ameliorates cognitive dysfunction and neurological injury after subarachnoid hemorrhage in rats by upregulating microRNA-31-5p targeting hypoxia-inducible factor 1 subunit alpha inhibitor.

Journal of physiology and pharmacology : an official journal of the Polish Physiological Society
Subarachnoid hemorrhage (SAH) is a hemorrhagic stroke with high short-term mortality that can lead to cognitive and neurological impairment. Accurate and appropriate treatment strategies are urgently needed. Nimodipine (NDP) can not only improve blood circulation in SAH patients but also repair ischemic neuronal damage.
S. Lu, T. Chen, J. Zhang
semanticscholar   +3 more sources

The expression of hypoxia-inducible factor-1 alpha in primary reproductive organs of the female yak (Bos grunniens) at different reproductive stages.

Reproduction in domestic animals = Zuchthygiene, 2020
The yak (Bos grunniens) is the most important livestock animal in high-altitude regions owing to its prominent adaptability to cold conditions, nutritional deficiencies, and hypoxia.
Jiangfeng Fan   +9 more
semanticscholar   +1 more source

Cobalt‐containing bioactive glass mimics vascular endothelial growth factor A and hypoxia inducible factor 1 function

, 2020
Bioactive glasses (BGs) have shown great potential for tissue regeneration and their composition flexibility allows the incorporation of different ions with physiological activities and therapeutic properties in the glass network.
Andréia Grossi Santos Laia   +9 more
semanticscholar   +1 more source

Cardioprotective effect of miR-214 in myocardial ischemic postconditioning by down-regulation of hypoxia inducible factor 1, alpha subunit inhibitor.

Cellular and molecular biology (Noisy-le-Grand, France), 2016
To determine the significance of miR—214 expression in ischemic post—conditioning. Sixty rats were grouped to establish animal models. Immuno— luminescence and chemical methods were used to detect oxidative stress indicators. Hemodynamics indexes were measured by carotid artery intubation, and ischemia and infarction areas by Evans ...
D-Y, Wan, Z, Zhang, H-H, Yang
openaire   +1 more source

Variation of Hypoxia Inducible Factor 1 alpha subunit (HIF-1α) and Prolyl Hydroxylase Domain 2 (PHD2) transcripts in Toxoplasma gondii infection: a preliminary comparative analysis. [PDF]

open access: possible, 2017
Toxoplasma gondii infects nearly one-third of the world population [1]. Virtually all species can be infected, but the parasite spreads more easily among some species (e.g. Pig) that infect humans more often than others (e.g. Horse). Investigating which host pathways are modulated by T.
Annamaria Castello   +4 more
openaire  

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