Results 231 to 240 of about 678,452 (368)

Hypoxia inducible factor‐1 (HIF‐l)‐mediated repression of cystic fibrosis transmembrane conductance regulator (CFTR) in the intestinal epithelium

, 2008
Wen Zheng, Johannes Kuhlicke, Kristian Jäckel, Holger K. Eltzschig, Anurag Kumar Singh, Markus Sjöblom, Brigitte Riederer, Cornelia Weinhold, Ursula Seidler, Sean P. Colgan, Jörn Karhausen   +10 more
openalex   +2 more sources

Ecto-5'-nucleotidase (CD73) regulation by hypoxia-inducible factor-1 mediates permeability changes in intestinal epithelia.

Journal of Clinical Investigation, 2002
Kristin Synnestvedt, G. Furuta, Katrina M. Comerford, N. Louis, Jörn Karhausen, H. Eltzschig, K. R. Hansen, L. Thompson, S. Colgan   +8 more
semanticscholar   +1 more source

USP9X as a Candidate Mediator of Prenatal Aspirin‐Induced Ovarian Reserve Reduction in Offspring Mice

Advanced Science, EarlyView.
This study suggests that prenatal aspirin exposure is associated with reduced ovarian reserve in offspring, associated with HDAC1‐linked epigenetic downregulation of Usp9x as a candidate mechanism. These preclinical findings provide new insights into fetal‐origin ovarian disorders and contribute to the evidence base concerning aspirin's gestational ...
Yating Li, Caiyun Ge, Wai Yen Yim, Hui Feng, Tiancheng Wu, Lu Chen, Qiaohua Xiong, Shumin Pan, Mei Wang, Huijun Chen, Yuanzhen Zhang, Hui Wang   +11 more
wiley   +1 more source

Regulating Tumor Metabolic Reprogramming with Biomimetic Co‐Delivery of Simvastatin and Kynureninase for Immunotherapy

Advanced Science, EarlyView.
After the intravenous injection of biomimetic and pH/ROS‐responsive PTSK@CRM, the nanoparticles can be accumulated in tumors and release Sim and KYNase to inhibit the tumor growth, regulate the metabolism of cholesterol and Kyn, and reverse the immunosuppressive tumor microenvironment.
Jiaxin Yin, Shengcai Yang, Zengguang Liu, Songchen Zhao, Siyu Sun, Ziling Liu, Quanshun Li   +6 more
wiley   +1 more source

Cystathionine gamma-lyase-mediated hypoxia inducible factor 1-alpha expression drives clear cell ovarian cancer progression. [PDF]

J Pathol
El-Naggar AM, Li Y, Turgu B, Ding Y, Wei L, Chen SY, Trigo-Gonzalez G, Kalantari F, Vallejos R, Lynch B, Senz J, Lum A, Douglas JM, Salamanca C, Thornton S, Qin Y, Parmar K, Spencer SE, Leung S, Woo MMM, Yong PJ, Zhang HF, Hughes CS, Negri GL, Wang Y, Morin GB, Sorensen PH, Huntsman DG.   +27 more
europepmc   +1 more source

Mitogen-Activated Protein Kinase Phosphatase-1 Is a Key Regulator of Hypoxia-Induced Vascular Endothelial Growth Factor Expression and Vessel Density in Lung [PDF]

, 2011
Kristin Shields, Evgeniy Panzhinskiy, Nana Burns, W. Michael Zawada, Mita Das   +4 more
openalex   +1 more source

Tendon Organoids Enable Functional Tendon Rejuvenation Through ALKBH5‐Dependent RNA Demethylation

Advanced Science, EarlyView.
FT organoids reverse the aged phenotype of tendon cells, reinstating a fetal‐like state. This breakthrough establishes a potent cell source for tendon tissue engineering, effectively advancing regenerative medicine. ABSTRACT Adult tendon injuries pose a major clinical challenge due to limited self‐repair capacity, resulting in suboptimal regeneration ...
Tian Qin, Aini Pan, Zhuoning Miao, Yanyan Zhao, Xianan Mo, Heng Sun, Chunmei Fan, Junyu Guo, Bingbing Wu, Weiliang Shen, Qiangqiang Zheng, Jun Lu, Xi Jiang, Zi Yin, Xiao Chen   +14 more
wiley   +1 more source

Targeting hypoxia-inducible factor-1 in a hypoxidative stress model protects retinal pigment epithelium cells from cell death and metabolic dysregulation. [PDF]

Cell Death Discov
Schubert A, Lobo Barbosa da Silva ME, Ambrock T, Terosian O, Malyshkina A, Padberg C, Larafa S, Matschke J, Fandrey J, Henning Y.   +9 more
europepmc   +1 more source

Retracted: Effects of Hypoxia-Inducible Factor 1 (HIF-1) Signaling Pathway on Acute Ischemic Stroke. [PDF]

Comput Math Methods Med, 2023
Methods In Medicine CAM.
europepmc   +1 more source

Molecular-Targeted Antitumor Agents. 19. Furospongolide from a Marine Lendenfeldia sp. Sponge Inhibits Hypoxia-Inducible Factor-1 Activation in Breast Tumor Cells

, 2008
Yang Liu, Rui Liu, Shui‐Chun Mao, Jody Morgan, Mika B. Jekabsons, Yudong Zhou, Dale G. Nagle   +6 more
openalex   +1 more source