Results 221 to 230 of about 136,903 (266)
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Hypoxia‐inducible factor‐1 and oncogenic signalling
BioEssays, 2004AbstractAn understanding of underlying mechanisms involved in the activation of HIF‐1 in response to both hypoxic stress and oncogenic signals has important implications for how these processes may become deregulated in human cancer. Changes in microenvironmental stimuli such as hypoxia and growth factors in combination with genetic lesions, such as ...
Bardos, JI, Athcroft, M
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Hypoxia‐Inducible Factor 1 Inhibitors
2007The tremendous progress in our understanding of the molecular mechanisms underlying the presence and consequences of hypoxia in human cancers has been accompanied by renewed enthusiasm for the development of therapeutic strategies targeting hypoxic cells signaling pathways.
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Hypoxia-Inducible Factor 1 and Preeclampsia: A New Perspective
Current Hypertension Reports, 2022Preeclampsia (PE) is a serious and distinct type of pregnancy-induced hypertension, with an incidence of 2-8% worldwide. PE is defined as pregnancy-related hypertension with proteinuria and peripheral edema after 20 weeks of gestation. Hypoxic placenta triggers the release of inflammatory and humoral substances into maternal circulation, leading to ...
Albogami, Sarah +10 more
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Regulation of angiogenesis by hypoxia-inducible factor 1
Critical Reviews in Oncology/Hematology, 2006Hypoxia is an imbalance between oxygen supply and demand that occurs in cancer and in ischemic cardiovascular disease. Hypoxia-inducible factor 1 (HIF-1) was originally identified as the transcription factor that mediates hypoxia-induced erythropoietin expression.
Kiichi, Hirota, Gregg L, Semenza
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Hypoxia-inducible factor 1 (HIF-1) in cancer
European Journal of Surgical Oncology (EJSO), 2004Hypoxia is a common feature of many cancers. It contributes to local and systemic tumour progression as well as potentially compromising radiotherapy and chemotherapy. Hypoxia-inducible factor 1 (HIF-1) is an essential component in changing the transcriptional response of tumours under hypoxia.
M, Quintero, N, Mackenzie, P A, Brennan
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Signal transduction to hypoxia-inducible factor 1
Biochemical Pharmacology, 2002Hypoxia-inducible factor 1 (HIF-1) is a transcriptional activator that functions as a master regulator of O2 homeostasis. HIF-1 target genes encode proteins that increase O2 delivery and mediate adaptive responses to O2 deprivation. HIF-1 activity is regulated by the cellular O2 concentration and by the major growth factor-stimulated signal ...
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Regulation of Vascularization by Hypoxia‐Inducible Factor 1
Annals of the New York Academy of Sciences, 2009Vascularization and vascular remodeling represent critical adaptive responses to tissue hypoxia that are mediated by hypoxia‐inducible factor 1 (HIF‐1). In patients with peripheral arterial disease, these responses are impaired by aging and diabetes, leading to critical limb ischemia and amputation.
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Hypoxia-Inducible Factors and Sphingosine 1-Phosphate Signaling
Anti-Cancer Agents in Medicinal Chemistry, 2011Hypoxia, defined as reduced tissue oxygen concentration, is a characteristic of solid tumors and is an indicator of unfavorable diagnosis in patients. At the cellular level, the adaptation to hypoxia is under the control of two related transcription factors, HIF-1α and HIF-2α (Hypoxia-Inducible Factor), which activate expression of genes promoting ...
Olivier, Cuvillier, Isabelle, Ader
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Hypoxia-Inducible Factor 1 in Lower Limb Ischemia
Vascular, 2006In the Western world, peripheral vascular disease (PVD) has a high prevalence and is associated with high morbidity and mortality. More patients are presenting with critical limb ischemia (CLI), the end stage of PVD, because of an increased life expectancy owing to improved medical care. In a large percentage of these patients, lower limb amputation is
Teik K, Ho +3 more
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Hypoxia-Inducible Factor 1 (HIF-1) Pathway
Science's STKE, 2007Hypoxia-inducible factor 1 (HIF-1) is a basic helix-loop-helix-PAS domain transcription factor that is expressed in all metazoan organisms and is composed of HIF-1α and HIF-1β subunits. Under hypoxic conditions, HIF-1 regulates the transcription of hundreds of genes in a cell type–specific manner. The HIF-1α subunit is regulated by O
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