Results 221 to 230 of about 229,207 (357)

A Nanoparticle‐Integrated Complete Manufacturing Pipeline of Chemically Engineered Exosomes

Advanced Science, EarlyView.
We report a novel manufacture technology of chemically engineered exosomes. The four steps of manufacturing, i.e., biogenesis, loading, isolation, and storage, are integrated by the use of a nanoparticle. The manufacture technology incorporates three innovative components, i.e., a new nano‐bio effect, a new composite nanoparticle, and a new isolation ...
Xiaowei Wen, Zixing Xu, Zerun Hao, Yanming Chen, Kai Xie, Haofan Yin, Xueying Wang, Jie Min, Sihan Sun, Baiding Chen, Chengxiu Ling, Mingming Xu, Yizhao Chen, Gang Ruan   +13 more
wiley   +1 more source

Immunohistochemical Expression of Hypoxia-Inducible Factor-1 Alpha in Oral Squamous Cell Carcinoma. [PDF]

Cureus
Thangjam N, Marbaniang E, Dey B, Harris C, Lynser D, Kalita P.   +5 more
europepmc   +1 more source

The transcription of the alarmin cytokine interleukin-1 alpha is controlled by hypoxia inducible factors 1 and 2 alpha in hypoxic cells [PDF]

, 2012
Peleg Rider, Irena Kaplanov, Marianna Romžová, Liora Bernardis, Alex Braiman, Elena Voronov, Ron N. Apte   +6 more
openalex   +1 more source

Single‐Cell Transcriptomics Reveals FLS2‐Dependent Hypoxia Signaling and ERF13‐Mediated Transcription During flg22‐Triggered Immunity

Advanced Science, EarlyView.
This study employs sc‐RNA sequencing, genetics, and phenotyping to systematically map the cell‐type‐specific immune responses triggered by flg22. It reveals FLS2‐dependent transcriptional reprogramming in epidermal and mesophyll cells, and uncovers crosstalk between immune and hypoxia signaling pathways.
Yaping Zhou, Aizhi Qin, Mengfan Li, Qianli Zhao, Luyao Kong, Lulu Yan, Chunyang Li, Hao Liu, Yinpeng Zhang, Jiani Long, Mengyu Liao, Mengmeng Zhou, Xiaoli Fan, Baozhen Wang, Wenxuan Kang, Shui Wang, Zhixin Liu, Xuwu Sun   +17 more
wiley   +1 more source

Alpha-ketoglutarate enhances adipose-derived stem cells survival in wound healing by hypoxia-inducible factor 1-alpha-mediated redox homeostasis and glycogen-dependent bioenergetics. [PDF]

World J Stem Cells
Dilimulati D, Dilimulati D, Cui L.
europepmc   +1 more source

1,3,8-Triazaspiro[4.5]decane-2,4-diones as Efficacious Pan-Inhibitors of Hypoxia-Inducible Factor Prolyl Hydroxylase 1–3 (HIF PHD1–3) for the Treatment of Anemia

, 2012
Petr Váchal, Shouwu Miao, Joan M. Pierce, Deodial Guiadeen, Vincent J. Colandrea, Matthew J. Wyvratt, Scott P. Salowe, Lisa M. Sonatore, James A. Milligan, Richard Hajdu, Anantha Gollapudi, Carol Keohane, Russell B. Lingham, Suzanne Mandala, Julie A. DeMartino, Xinchun Tong, Michael W. Wolff, Dietrich Steinhuebel, G. R. KIECZYKOWSKI, Fred J. Fleitz, Kevin T. Chapman, John Athanasopoulos, Gregory C. Adam, Can D. Akyuz, Dhirendra K. Jena, Jeffrey W. Lusen, Juncai Meng, Benjamin D. Stein, Lei Xia, Edward C. Sherer, Jeffrey J. Hale   +30 more
openalex   +1 more source

Hypoxia Inducible Factor-1 Activation by Prolyl 4-Hydroxylase-2 Gene Silencing Attenuates Myocardial Ischemia Reperfusion Injury [PDF]

, 2005
Ramesh Natarajan, Fadi N. Salloum, Bernard Fisher, Rakesh C. Kukreja, Alpha A. Fowler   +4 more
openalex   +1 more source

A Radioresistant‐Tumor‐Targeted Nanoparticle for X‐Ray‐Controlled Nitric Oxide Release to Potentiate Radiotherapy

Advanced Science, EarlyView.
The PBTN targets GRP78 and, upon X‐ray irradiation, generates ONOO− to induce immunogenic cell death, thereby activating CD8+ T cells and establishing a systemic antitumor immune response. ABSTRACT Nitric oxide (NO) treated radioresistant tumors by relieving hypoxia and blocking DNA repair, but its nonselective toxicity has precluded therapeutic use ...
Wanze Zhang, Xiaoyan Yin, Ting Wang, Hongfu Zhao, Zhipeng Zhao, Jinbao Wang, Cheng Tao, Xuanchu Ge, Yanze Li, Linlin Liu, Fuxin Xue   +10 more
wiley   +1 more source

Dual Roles of Hypoxia-Inducible Factor 1 in Acute Lung Injury: Tissue-Specific Mechanisms and Therapeutic Modulation. [PDF]

Cells
Jia J, Zhang Y, Lu Q, Tian S, Zhao Y, Fan H.   +5 more
europepmc   +1 more source

Beclin-1-independent autophagy positively regulates internal ribosomal entry site-dependent translation of hypoxia-inducible factor 1α under nutrient deprivation [PDF]

, 2014
Ching-An Wu, Duen-Yi Huang, Wan‐Wan Lin   +2 more
openalex   +1 more source