Results 351 to 360 of about 649,237 (386)

Honokiol inhibits hypoxia-inducible factor-1 pathway

International Journal of Radiation Biology, 2011
Hypoxia-inducible factor-1α (HIF-1α) plays a pivotal role in the reaction of a tumour to hypoxia. In this study, we examined the inhibitory effect of a natural compound, honokiol, on HIF-1α activity and tumour growth in combination with radiation.The inhibitory effect of honokiol on hypoxia-responsive element (HRE) controlled luciferase activity and ...
Yi Sheng Shih, Fu Chih Hsu, Hong Ming Wang, Sang Hue Yen, Ming Yuan Chen, Meei-Ling Sheu, Keng Hsin Lan, Keng Li Lan, Ren Shyan Liu   +8 more
openaire   +3 more sources

Dexamethasone impairs hypoxia-inducible factor-1 function

Biochemical and Biophysical Research Communications, 2008
Hypoxia-inducible factor-1 (HIF-1) is a heterodimeric transcription-factor composed of alpha- and beta-subunits. HIF-1 is not only necessary for the cellular adaptation to hypoxia, but it is also involved in inflammatory processes and wound healing. Glucocorticoids (GC) are therapeutically used to suppress inflammatory responses.
G. Huck, Thomas Hellwig-Bürgel, Wolfgang Jelkmann, Daniel P. Stiehl, A.E. Wagner   +4 more
openaire   +3 more sources

Hypoxia-Inducible Factors and Sphingosine 1-Phosphate Signaling

Anti-Cancer Agents in Medicinal Chemistry, 2011
Hypoxia, defined as reduced tissue oxygen concentration, is a characteristic of solid tumors and is an indicator of unfavorable diagnosis in patients. At the cellular level, the adaptation to hypoxia is under the control of two related transcription factors, HIF-1α and HIF-2α (Hypoxia-Inducible Factor), which activate expression of genes promoting ...
Isabelle Ader, Olivier Cuvillier
openaire   +3 more sources

HIF‐1: hypoxia‐inducible factor or dysoxia‐inducible factor?

The FASEB Journal, 2006
Hypoxia-inducible factor 1 (HIF-1) activates the transcription of genes involved in diverse aspects of cellular and integrative physiology, including energy metabolism, cell growth, survival, invasion, migration or angiogenesis. The activity of this transcription factor is known to be increased by hypoxia, but also by a growing number of apparently ...
openaire   +3 more sources

Oxygen(es) and the hypoxia-inducible factor-1.

Biological chemistry, 1997
The hypoxia-inducible factor-1 (HIF-1) is a basic-helix-loop-helix (bHLH) heterodimeric transcription factor activated by reductions in oxygen concentration (hypoxia). Activated HIF-1 upregulates expression of genes involved in the adaptation of higher organisms to hypoxic conditions, caused by e.g.
Wenger, R H, Gassmann, M
openaire   +2 more sources

Molecular Biology of Hypoxia-Inducible Factor-1

1999
The hypoxia-inducible factor-1 (HIF-1) is a basic-helix-loop-helix-PAS heterodimeric transcription factor that confers oxygen-regulated expression to a number of genes involved in oxygen homeostasis including erythropoietin (Epo), transferrin, glycolytic enzymes, and vascular endothelial growth factor (VEGF).
Max Gassmann, Roland H. Wenger
openaire   +2 more sources

Systemic therapy for hormone receptor‐positive/human epidermal growth factor receptor 2‐negative early stage and metastatic breast cancer

Ca-A Cancer Journal for Clinicians, 2023
Laura A Huppert, Hope S Rugo
exaly  

Hypoxia Inducible Factor-1 and VEGF Induction

2008
Vascular endothelial growth factor (VEGF) is the key molecule implicated in the pathogenesis of retinal angiogenesis. Expression of the VEGF gene is increased in response to hypoxia. This increase results from increased transcription as well as increased stabilization of the VEGF transcript.
openaire   +2 more sources

Hypoxia-Inducible Factor-1 [PDF]

, 2008
openaire   +1 more source

Current treatment and recent progress in gastric cancer

Ca-A Cancer Journal for Clinicians, 2021
Smita S Joshi, Brian D Badgwell
exaly