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Regulation of Vascularization by Hypoxia‐Inducible Factor 1
Annals of the New York Academy of Sciences, 2009Vascularization and vascular remodeling represent critical adaptive responses to tissue hypoxia that are mediated by hypoxia‐inducible factor 1 (HIF‐1). In patients with peripheral arterial disease, these responses are impaired by aging and diabetes, leading to critical limb ischemia and amputation.
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Regulation of oxygen homeostasis by hypoxia-inducible factor 1.
Physiology, 2009G. Semenza
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Oxygen(es) and the hypoxia-inducible factor-1.
Biological chemistry, 1997The hypoxia-inducible factor-1 (HIF-1) is a basic-helix-loop-helix (bHLH) heterodimeric transcription factor activated by reductions in oxygen concentration (hypoxia). Activated HIF-1 upregulates expression of genes involved in the adaptation of higher organisms to hypoxic conditions, caused by e.g.
Wenger, R H, Gassmann, M
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Hypoxia-inducible factor 1: oxygen homeostasis and disease pathophysiology.
Trends in Molecular Medicine, 2001G. Semenza
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Hypoxia-inducible factor 1: master regulator of O2 homeostasis.
Current Opinion in Genetics and Development, 1998G. Semenza
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