Results 91 to 100 of about 1,344,802 (358)

Hypoxia sustains glioblastoma radioresistance through ERKs/DNA-PKcs/HIF-1α functional interplay [PDF]

, 2014
The molecular mechanisms by which glioblastoma multiforme (GBM) refracts and becomes resistant to radiotherapy treatment remains largely unknown. This radioresistance is partly due to the presence of hypoxic regions, which are frequently found in GBM ...
Cerasani, Manuela, Ciccarelli, Carmela, Di Cesare, Ernesto, Di Genova, Daniela, Festuccia, Claudio, Ficorella, Corrado, Fratticci, Amato, Gravina, Giovanni Luca, Mancini, Marta, Marampon, Francesco, Popov, Vladimir M, Zani, Bianca Maria   +11 more
core   +1 more source

Targeting Hypoxia-Inducible Factors for the Treatment of Anemia in Chronic Kidney Disease Patients

American Journal of Nephrology, 2017
Background: Anemia, a common complication of chronic kidney disease (CKD), has previously been attributed primarily to decreased production of erythropoietin.
F. Locatelli, S. Fishbane, G. Block, I. Macdougall   +3 more
semanticscholar   +1 more source

Hypoxia-Inducible Factor 1

Chest, 1998
Hypoxia-inducible factor 1 (HIF-1) mediates adaptive responses to hypoxia by activating the transcription of hundreds of target genes. The expression and activity of HIF-1 are oxygen-regulated, which provides a direct mechanism for transducing changes in cellular oxygenation to changes in gene expression.
Gregg L. Semenza, Faton Agani, Narayan Iyer, Bing-Hua Jiang, Sandra Leung, Charles Wiener, Aimee Yu   +6 more
openaire   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Transcriptional Responses of Different Brain Cell Types to Oxygen Decline

Brain Sciences
Brain hypoxia is associated with a wide range of physiological and clinical conditions. Although oxygen is an essential constituent of maintaining brain functions, our understanding of how specific brain cell types globally respond and adapt to ...
Camille Ravel-Godreuil, Ethan R. Roy, Srinivas N. Puttapaka, Sanming Li, Yanyu Wang, Xiaoyi Yuan, Holger K. Eltzschig, Wei Cao   +7 more
doaj   +1 more source

HIF-1α Contributes to Hypoxia-induced Invasion and Metastasis of Esophageal Carcinoma via Inhibiting E-cadherin and Promoting MMP-2 Expression [PDF]

, 2012
Hypoxia-inducible factor-1α (HIF-1α) has been found to enhance tumor invasion and metastasis, but no study has reported its action in esophageal carcinoma.
Cheng, Yun-Jie, Jing, Shao-Wu, Kuroda, Masahiro, Liu, Qing, Su, Jing-Wei, Sun, Guo-Gui, Wang, Ya-Di, Yang, Cong-Rong   +7 more
core   +1 more source

Inhibitor of nuclear factor‐kappaB alpha derepresses hypoxia‐inducible factor‐1 during moderate hypoxia by sequestering factor inhibiting hypoxia‐inducible factor from hypoxia‐inducible factor 1α [PDF]

The FEBS Journal, 2009
Hypoxia and inflammation often develop concurrently in numerous diseases, and both hypoxia‐inducible factor (HIF)‐1α and nuclear factor‐kappaB (NF‐κB) are key transcription factors of stress response genes. An NF‐κB inhibitor, inhibitor of NF‐κBα (IκBα), was found to interact with factor inhibiting HIF (FIH) and to be hydroxylated by FIH.
Dong Hoon, Shin, Shan Hua, Li, Seung-Won, Yang, Byung Lan, Lee, Myung Kyu, Lee, Jong-Wan, Park   +5 more
openaire   +2 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Calcitriol Suppresses HIF-1 and HIF-2 Transcriptional Activity by Reducing HIF-1/2α Protein Levels via a VDR-Independent Mechanism

Cells, 2020
Hypoxia-inducible transcription factors 1 and 2 (HIFs) are major mediators of cancer development and progression and validated targets for cancer therapy.
Ioanna-Maria Gkotinakou, Eleni Kechagia, Kalliopi Pazaitou-Panayiotou, Ilias Mylonis, Panagiotis Liakos, Andreas Tsakalof   +5 more
doaj   +1 more source