Results 121 to 130 of about 1,344,802 (358)

DDX3X induces mesenchymal transition of endothelial cells by disrupting BMPR2 signaling

FEBS Open Bio, EarlyView.
Elevated DDX3X expression led to downregulation of BMPR2, a key regulator of endothelial homeostasis and function. Our co‐immunoprecipitation assays further demonstrated a molecular interaction between DDX3X and BMPR2. Notably, DDX3X promoted lysosomal degradation of BMPR2, thereby impairing its downstream signaling and facilitating endothelial‐to ...
Yu Zhang, Jing Wang, De‐Hui Qian, Yang‐Fan Lv, Tian‐Le Cheng, Da‐Peng Wang, Jing Zhang, Ye Fan   +7 more
wiley   +1 more source

Variants of the low oxygen sensors EGLN1 and HIF-1AN associated with acute mountain sickness. [PDF]

, 2014
Two low oxygen sensors, Egl nine homolog 1 (EGLN1) and hypoxia-inducible factor 1-α inhibitor (HIF-1AN), play pivotal roles in the regulation of HIF-1α, and high altitude adaption may be involved in the pathology of acute mountain sickness (AMS).
Huang, Lan, Jin, Jun, Li, Huijie, Qin, Jun, Zhang, Enhao, Zhang, Jihang   +5 more
core   +3 more sources

Hypoxia-inducible factors regulate pluripotency factor expression by ZNF217- and ALKBH5-mediated modulation of RNA methylation in breast cancer cells

OncoTarget, 2016
Exposure of breast cancer cells to hypoxia increases the percentage of breast cancer stem cells (BCSCs), which are required for tumor initiation and metastasis, and this response is dependent on the activity of hypoxia-inducible factors (HIFs).
Chuanzhao Zhang, W. Zhi, Haiquan Lu, Debangshu Samanta, Ivan Chen, E. Gabrielson, G. Semenza   +6 more
semanticscholar   +1 more source

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source

Mitochondrial composition and function under the control of hypoxia

Redox Biology, 2017
Hypoxia triggers several mechanisms to adapt cells to a low oxygen environment. Mitochondria are major consumers of oxygen and a potential source of reactive oxygen species (ROS).
Dominik C. Fuhrmann, Bernhard Brüne
doaj   +1 more source

Early redox activities modulate Xenopus tail regeneration. [PDF]

, 2018
Redox state sustained by reactive oxygen species (ROS) is crucial for regeneration; however, the interplay between oxygen (O2), ROS and hypoxia-inducible factors (HIF) remains elusive.
Ferreira, Fernando, Luxardi, Guillaume, Raghunathan, VijayKrishna, Zhao, Min, Zhu, Kan   +4 more
core   +2 more sources

Hypoxia and hypoxia-inducible factors in neuroblastoma

Cell and Tissue Research, 2017
Hypoxia (i.e., low oxygen levels) is a known feature of aggressive tumors. Cells, including tumor cells, respond to conditions of insufficient oxygen by activating a transcriptional program mainly driven by hypoxia-inducible factors (HIF)-1 and HIF-2 ...
S. Påhlman, S. Mohlin
semanticscholar   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Hypoxia in Alzheimer's disease: effects of hypoxia inducible factors

Neural Regeneration Research, 2021
Halimatu Hassan, Ruoli Chen
doaj   +1 more source

Mouse models for preeclampsia: disruption of redox-regulated signaling [PDF]

, 2009
The concept that oxidative stress contributes to the development of human preeclampsia has never been tested in genetically-defined animal models. Homozygous deletion of catechol-Omethyl transferase (Comt-/-) in pregnant mice leads to human preeclampsia ...
A Malassine, AC Epstein, AM Carter, AM Zafari, Anne E Chambers, AP MacKay, BJ Hawkins, C Moser, C Peyssonnaux, CW Redman, D Berg, D Gerald, DS Hoffmann, DS Tannetta, EL Bell, EL Pagé, FX Yi, GL Semenza, H Pelicano, Harpal Randeva, I Thaler, J Golab, J Sugawara, JA Martin, K Kanasaki, L Duley, L Wood, M Geiszt, M Ushio-Fukai, M Wang, N Kanayama, NS Chandel, P Huang, PH Maxwell, R Dworakowski, R Pijnenborg, RD Martin, RK Bruick, RW Redline, S Banerjee, S Lamond, S Melov, S Muzaffar, S Nemoto, SL Adamson, Subhasis Banerjee, T Cramer, T Torbergsen, Y Liu, Y Pan, Y Wang, YA Suh   +51 more
core   +4 more sources