HER2 regulates HIF-2α and drives an increased hypoxic response in breast cancer
Breast Cancer Research, 2019 Background Tumour hypoxia is a driver of breast cancer progression associated with worse prognosis and more aggressive disease. The cellular response to hypoxia is mediated by the hypoxia-inducible transcription factors HIF-1 and HIF-2, whose ...
Edward J. Jarman +7 more
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HIF-1α, a novel piece in the NF-κB puzzle [PDF]
, 2015 Hypoxia, or low oxygen availability, is an important physiological stimulus for multicellular organisms. Molecularly, hypoxia induces a transcriptional programme directed at restoration of oxygen homeostasis and cellular survival.
Bandarra, Daniel, Rocha, Sonia
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The key role of nitric oxide in hypoxia: hypoxic vasodilation and energy supply-demand matching [PDF]
, 2013 Significance: a mismatch between energy supply and demand induces tissue hypoxia with the potential to cause cell death and organ failure. Whenever arterial oxygen concentration is reduced, increases in blood flow - 'hypoxic vasodilation' - occur in an ...
Alex Dyson +23 more
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Allogeneic mesenchymal stromal cells overexpressing mutant human Hypoxia-inducible factor 1-α (HIF1-α) in an ovine model of acute myocardial infarction [PDF]
, 2016 Background-Bone marrow mesenchymal stromal cells (BMMSCs) are cardioprotective in acute myocardial infarction (AMI) because of release of paracrine angiogenic and prosurvival factors.
Crottogini, Alberto José +11 more
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Hypoxia-inducible factors in OSCC
Cancer Letters, 2011 Oral squamous cell carcinoma (OSCC) is a characteristic locally aggressive tumor in which hypoxia levels are very high, causing a low response to chemotherapy and providing basic resistance to anticancer drugs. Tumoral hypoxia directly depends on hypoxia-inducible factors (HIF).
Pérez Sayáns, Mario +5 more
openaire +3 more sources
Hypoxia and HIF activation as a possible link between sepsis and thrombosis
Thrombosis Journal, 2019 Risk factors for thrombosis include hypoxia and sepsis, but the mechanisms that control sepsis-induced thrombus formation are incompletely understood.
Colin E. Evans
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Special Issue: Hypoxia-Inducible Factors: Regulation and Therapeutic Potential
Biomedicines, 2021 Oxygen (O2) is an essential molecule [...]
Kiichi Hirota
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MicroRNAs regulate T-cell production of interleukin-9 and identify hypoxia-inducible factor-2a as an important regulator of T helper 9 and regularoty T-cell differentiation [PDF]
, 2016 MicroRNAs (miRNAs) regulate many aspects of helper T cell (Th) development and function. Here we found that they are required for the suppression of interleukin‐9 (IL‐9) expression in Th9 cells and other Th subsets. Two highly related miRNAs (miR‐15b and
Baumjohann +37 more
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hypoxia-inducible factors activate CD133 promoter through ETS family transcription factors. [PDF]
PLoS ONE, 2013 CD133 is a cellular surface protein that has been reported to be a cancer stem cell marker, and thus it is considered to be a potential target for cancer treatment. However, the mechanism regulating CD133 expression is not yet understood.
Shunsuke Ohnishi +11 more
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Hypoxia-Inducible Factors Regulate Osteoclasts in Health and Disease
Frontiers in Cell and Developmental Biology, 2021 Hypoxia-inducible factors (HIFs) have become key transcriptional regulators of metabolism, angiogenesis, erythropoiesis, proliferation, inflammation and metastases. HIFs are tightly regulated by the tissue microenvironment.
Xianyi Meng +3 more
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