Results 51 to 60 of about 1,301,346 (361)
HER2 regulates HIF-2α and drives an increased hypoxic response in breast cancer
Breast Cancer Research, 2019 Background Tumour hypoxia is a driver of breast cancer progression associated with worse prognosis and more aggressive disease. The cellular response to hypoxia is mediated by the hypoxia-inducible transcription factors HIF-1 and HIF-2, whose ...
Edward J. Jarman +7 more
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Hypoxia and HIF activation as a possible link between sepsis and thrombosis
Thrombosis Journal, 2019 Risk factors for thrombosis include hypoxia and sepsis, but the mechanisms that control sepsis-induced thrombus formation are incompletely understood.
Colin E. Evans
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hypoxia-inducible factors activate CD133 promoter through ETS family transcription factors. [PDF]
PLoS ONE, 2013 CD133 is a cellular surface protein that has been reported to be a cancer stem cell marker, and thus it is considered to be a potential target for cancer treatment. However, the mechanism regulating CD133 expression is not yet understood.
Shunsuke Ohnishi +11 more
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The role of hypoxia-inducible factors in renal fibrosis
Journal of the Formosan Medical Association, 2013 Szu-Yu Pan +2 more
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Hypoxia up-regulates SERPINB3 through HIF-2\u3b1 in human liver cancer cells. [PDF]
, 2015 SERPINB3 is a cysteine-proteases inhibitor up-regulated in a significant number of cirrhotic patients carrying hepatocellular carcinoma (HCC) and recently proposed as a prognostic marker for HCC early recurrence.
Autelli, Riccardo +20 more
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Hypoxia-Inducible Factors Regulate Osteoclasts in Health and Disease
Frontiers in Cell and Developmental Biology, 2021 Hypoxia-inducible factors (HIFs) have become key transcriptional regulators of metabolism, angiogenesis, erythropoiesis, proliferation, inflammation and metastases. HIFs are tightly regulated by the tissue microenvironment.
Xianyi Meng +3 more
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Gallstones: Bad Company for the Steatotic Liver [PDF]
, 2017 Gallstones are very frequent worldwide with a prevalence ranging from 10% to 15% in Western countries to
Alvaro, Domenico
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Endocrine targets of hypoxia-inducible factors [PDF]
Journal of Endocrinology, 2017 Endocrine is an important and tightly regulated system for maintaining body homeostasis. Endocrine glands produce hormones, which are released into blood stream to guide the target cells responding to all sorts of stimulations. For maintaining body homeostasis, the secretion and activity of a particular hormone needs to be adjusted in responding to ...
Hsiu Chi Lee, Shaw Jenq Tsai
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Biological Research, 2013 This study analyzed the time dependence decay of the mRNA of selected genes important for the hypoxia response. The genes chosen were the two isoforms of hypoxia-inducible factors, the three isoforms of the prolyl hydroxylase domain protein, the vascular
Alice Panariti +2 more
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MicroRNAs regulate T-cell production of interleukin-9 and identify hypoxia-inducible factor-2a as an important regulator of T helper 9 and regularoty T-cell differentiation [PDF]
, 2016 MicroRNAs (miRNAs) regulate many aspects of helper T cell (Th) development and function. Here we found that they are required for the suppression of interleukin‐9 (IL‐9) expression in Th9 cells and other Th subsets. Two highly related miRNAs (miR‐15b and
Baumjohann +37 more
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