Results 31 to 40 of about 1,553,027 (326)
Journal of Biological Chemistry, 2020 The gastrointestinal tract is a highly proliferative and regenerative tissue. The intestine also harbors a large and diverse microbial population collectively called the gut microbiome (microbiota).
Rashi Singhal, Y. Shah
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Hypoxia Signaling Pathway in Stem Cell Regulation: Good and Evil [PDF]
, 2018 Purpose of Review: This review summarizes the role of hypoxia and hypoxia-inducible factors (HIFs) in the regulation of stem cell biology, specifically focusing on maintenance, differentiation, and stress responses in the context of several stem cell ...
Aljoufi, Arafat +3 more
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Hypoxia-Inducible Factor in Thyroid Carcinoma [PDF]
Journal of Thyroid Research, 2011 Intratumoural hypoxia (low oxygen tension) is associated with aggressive disease and poor prognosis. Hypoxia-inducible factor-1 is a transcription factor activated by hypoxia that regulates the expression of genes that promote tumour cell survival, progression, metastasis, and resistance to chemo/radiotherapy.
Burrows, Natalie +4 more
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Metabolic Regulation of Hypoxia-Inducible Factors in Hypothalamus
Frontiers in Endocrinology, 2021 The earliest hypoxia-inducible factor (HIF) function was to respond to hypoxia or hypoxic conditions as a transcription factor. Recent studies have expanded our understanding of HIF, and a large amount of evidence indicates that HIF has an essential ...
Dan Du +4 more
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The tumour microenvironment links complement system dysregulation and hypoxic signalling. [PDF]
, 2018 The complement system is an innate immune pathway typically thought of as part of the first line of defence against "non-self" species. In the context of cancer, complement has been described to have an active role in facilitating cancer-associated ...
Giaccia, Amato J +4 more
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Hypoxia-inducible factors in the kidney [PDF]
American Journal of Physiology-Renal Physiology, 2006 Tissue hypoxia not only occurs under pathological conditions but is also an important microenvironmental factor that is critical for normal embryonic development. Hypoxia-inducible factors HIF-1 and HIF-2 are oxygen-sensitive basic helix-loop-helix transcription factors, which regulate biological processes that facilitate both oxygen delivery and ...
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Haematologica, 2012 Background Iron metabolism, regulated by the iron hormone hepcidin, and oxygen homeostasis, dependent on hypoxia-inducible factors, are strongly interconnected.
Maria Mastrogiannaki +6 more
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Functional Repercussions of Hypoxia-Inducible Factor-2α in Idiopathic Pulmonary Fibrosis
Cells, 2022 Hypoxia and hypoxia-inducible factors (HIFs) are essential in regulating several cellular processes, such as survival, differentiation, and the cell cycle; this adaptation is orchestrated in a complex way.
Ana Karen Torres-Soria +14 more
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Plasma from Volunteers Breathing Helium Reduces Hypoxia-Induced Cell Damage in Human Endothelial Cells-Mechanisms of Remote Protection Against Hypoxia by Helium. [PDF]
, 2019 PurposeRemote ischemic preconditioning protects peripheral organs against prolonged ischemia/reperfusion injury via circulating protective factors. Preconditioning with helium protected healthy volunteers against postischemic endothelial dysfunction.
Augustijn, Quinten JJ +7 more
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SnapShot: Hypoxia-Inducible Factors
Cell, 2015 Molecular oxygen (O2) is a key substrate for mitochondrial ATP production and numerous intracellular biochemical reactions. The maintenance of O2 homeostasis is therefore essential for the survival of most species. During O2 deprivation, mammalian cells rely on multiple adaptations mediated by the hypoxia-inducible factors (HIFs), mTOR, autophagy, and ...
Lee, Kyoung Eun, Simon, M. Celeste
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