Results 21 to 30 of about 1,553,027 (326)
Regulation of erythropoiesis by hypoxia-inducible factors [PDF]
Blood Reviews, 2013 A classic physiologic response to systemic hypoxia is the increase in red blood cell production. Hypoxia-inducible factors (HIFs) orchestrate this response by inducing cell-type specific gene expression changes that result in increased erythropoietin (EPO) production in kidney and liver, in enhanced iron uptake and utilization and in adjustments of the
Volker Hans Haase
exaly +3 more sources
Hypoxia inducible factors in hepatocellular carcinoma
Oncotarget, 2017 Hepatocellular carcinoma is one of the most prevalent and lethal cancers with limited therapeutic options. Pathogenesis of this disease involves tumor hypoxia and the activation of hypoxia inducible factors.
Chu Chen, Tao Lou
semanticscholar +4 more sources
Pharmacologic Targeting of Hypoxia-Inducible Factors.
Annual Review of Pharmacology and Toxicology, 2019 Hypoxia-inducible factors (HIFs) control transcriptional responses to reduced O2 availability. HIFs are heterodimeric proteins composed of an O2-regulated HIF-α subunit and a constitutively expressed HIF-1β subunit.
G. Semenza
semanticscholar +3 more sources
Hypoxia and hypoxia-inducible factors in neuroblastoma [PDF]
Cell and Tissue Research, 2017 Hypoxia (i.e., low oxygen levels) is a known feature of aggressive tumors. Cells, including tumor cells, respond to conditions of insufficient oxygen by activating a transcriptional program mainly driven by hypoxia-inducible factors (HIF)-1 and HIF-2 ...
S. Påhlman, S. Mohlin
semanticscholar +3 more sources
Hypoxia-Driven Effects in Cancer: Characterization, Mechanisms, and Therapeutic Implications
Cells, 2021 Hypoxia, a common feature of solid tumors, greatly hinders the efficacy of conventional cancer treatments such as chemo-, radio-, and immunotherapy. The depletion of oxygen in proliferating and advanced tumors causes an array of genetic, transcriptional,
Rachel Shi, Chengheng Liao, Qing Zhang
doaj +1 more source
Clinical investigation of hypoxia-inducible factors: getting there [PDF]
The Journal of Clinical InvestigationGregg L. Semenza
doaj +2 more sources
Knockdown of myeloid cell hypoxia-inducible factor-1α ameliorates the acute pathology in DSS-induced colitis. [PDF]
PLoS ONE, 2017 Inflammation and hypoxia are hallmarks of inflammatory bowel disease. Low oxygen levels activate hypoxia-inducible factors as central transcriptional regulators of cellular responses to hypoxia, particularly in myeloid cells where hypoxia-inducible ...
Veronika Bäcker +4 more
doaj +1 more source
The human side of hypoxia‐inducible factor [PDF]
British Journal of Haematology, 2008 SummaryWhen humans are exposed to hypoxia, systemic and intracellular changes operate together to minimise hypoxic injury and restore adequate oxygenation. Emerging evidence indicates that the hypoxia‐inducible factor (HIF) family of transcription factors plays a central regulatory role in these homeostatic changes at both the systemic and cellular ...
Smith, T, Robbins, P, Ratcliffe, P
openaire +3 more sources
Effects of exposure to a DNA damaging agent on the hypoxia inducible factors in organogenesis stage mouse limbs. [PDF]
PLoS ONE, 2012 Hypoxia plays a critical role in coordinating cell survival, differentiation and death in normal embryogenesis; during limb pattern formation, hypoxia affects two key processes, chondrogenesis and cell death.
Chunwei Huang, Barbara F Hales
doaj +1 more source
Advances in Hypoxia-Inducible Factor Biology [PDF]
Cell Metabolism, 2018 Hypoxia-inducible factor (HIF), a central regulator for detecting and adapting to cellular oxygen levels, transcriptionally activates genes modulating oxygen homeostasis and metabolic activation. Beyond this, HIF influences many other processes. Hypoxia, in part through HIF-dependent mechanisms, influences epigenetic factors, including DNA methylation ...
Choudhry, H, Harris, A
openaire +3 more sources