Results 11 to 20 of about 1,552,928 (227)
Hypoxia and Hypoxia-Inducible Factors in Kidney Injury and Repair
Cells, 2019 Acute kidney injury (AKI) is a major kidney disease characterized by an abrupt loss of renal function. Accumulating evidence indicates that incomplete or maladaptive repair after AKI can result in kidney fibrosis and the development and progression of ...
Shaoqun Shu +6 more
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Hypoxic stress and hypoxia-inducible factors in leukemias [PDF]
Frontiers in Oncology, 2022 To cope with hypoxic stress, ancient organisms have developed evolutionally conserved programs centered on hypoxia-inducible transcriptional factors (HIFs).
Daniela Magliulo, Rosa Bernardi
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Renoprotective Role of Hypoxia-Inducible Factors and the Mechanism [PDF]
Kidney Diseases, 2021 Background: The kidney requires abundant blood supply, and oxygen is transmitted by diffusion through blood vessels. Most physiological metabolism of the kidney depends on oxygen, so it is very sensitive to oxygen. An increasing pool of evidence suggests
Qiu-Yu Li +4 more
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Pulmonary Thrombosis Promotes Tumorigenesis via Myeloid Hypoxia-Inducible Factors [PDF]
Biomolecules, 2022 Cancer patients have a greater risk of thrombosis than individuals without cancer. Conversely, thrombosis is a diagnostic predictor of cancer, but the mechanisms by which thrombosis promotes tumor propagation are incompletely understood.
Xiao Lu +3 more
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Hypoxia-Inducible Factors and the Regulation of Lipid Metabolism
Cells, 2019 Oxygen deprivation or hypoxia characterizes a number of serious pathological conditions and elicits a number of adaptive changes that are mainly mediated at the transcriptional level by the family of hypoxia-inducible factors (HIFs).
Ilias Mylonis +2 more
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Hypoxia-Inducible Factors [PDF]
RCSB Protein Data Bank, 2019 D. Goodsell
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Maintenance of redox homeostasis by hypoxia-inducible factors
Redox Biology, 2017 Oxidative phosphorylation enables cells to generate the large amounts of ATP required for development and maintenance of multicellular organisms. However, under conditions of reduced O2 availability, electron transport becomes less efficient, leading to ...
Debangshu Samanta, Gregg L. Semenza
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Targeting hypoxia-inducible factors: therapeutic opportunities and challenges [PDF]
Nat Rev Drug Discov, 2023 Xiaoyi Yuan +4 more
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Sorafenib resistance in hepatocarcinoma: role of hypoxia-inducible factors
Experimental and Molecular Medicine, 2018 Liver cancer: overcoming treatment resistance Targeting hypoxia-inducible factors (HIFs), regulatory proteins induced by low oxygen levels, could increase the effectiveness of sorafenib, the only systemic therapy approved for advanced liver cancer.
Carolina Méndez-Blanco +4 more
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Transcriptional regulation by hypoxia inducible factors [PDF]
Critical Reviews in Biochemistry and Molecular Biology, 2014 The cellular response to oxygen deprivation is governed largely by a family of transcription factors known as Hypoxia Inducible Factors (HIFs). This review focuses on the molecular mechanisms by which HIFs regulate the transcriptional apparatus to enable the cellular and organismal response to hypoxia.
V. L. Dengler, M. Galbraith, J. Espinosa
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