Results 51 to 60 of about 1,553,027 (326)
HER2 regulates HIF-2α and drives an increased hypoxic response in breast cancer
Breast Cancer Research, 2019 Background Tumour hypoxia is a driver of breast cancer progression associated with worse prognosis and more aggressive disease. The cellular response to hypoxia is mediated by the hypoxia-inducible transcription factors HIF-1 and HIF-2, whose ...
Edward J. Jarman +7 more
doaj +1 more source
Interleukin-1β sequesters hypoxia inducible factor 2α to the primary cilium. [PDF]
, 2013 BACKGROUND: The primary cilium coordinates signalling in development, health and disease. Previously we have shown that the cilium is essential for the anabolic response to loading and the inflammatory response to interleukin-1β (IL-1β).
AC Lin +60 more
core +1 more source
Hypoxia in the Initiation and Progression of Neuroblastoma Tumours [PDF]
, 2020 Neuroblastoma is the most frequent extracranial solid tumour in children, causing 10% of all paediatric oncology deaths. It arises in the embryonic neural crest due to an uncontrolled behaviour of sympathetic nervous system progenitors, giving rise to ...
Gómez Muñoz, María Ángeles +3 more
core +1 more source
Hypoxia-inducible factors and innate immunity in liver cancer.
Journal of Clinical Investigation, 2020 The liver has strong innate immunity to counteract pathogens from the gastrointestinal tract. During the development of liver cancer, which is typically driven by chronic inflammation, the composition and biological roles of the innate immune cells are ...
V. W. Yuen, C. C. Wong
semanticscholar +1 more source
Endocrine targets of hypoxia-inducible factors [PDF]
Journal of Endocrinology, 2017 Endocrine is an important and tightly regulated system for maintaining body homeostasis. Endocrine glands produce hormones, which are released into blood stream to guide the target cells responding to all sorts of stimulations. For maintaining body homeostasis, the secretion and activity of a particular hormone needs to be adjusted in responding to ...
Hsiu-Chi, Lee, Shaw-Jenq, Tsai
openaire +2 more sources
Nuclear β-arrestin1 is a critical cofactor of hypoxia-inducible factor-1α signaling in endothelin-1-induced ovarian tumor progression [PDF]
, 2016 Hypoxia-inducible factor-1α (HIF-1α) mediates the response to hypoxia or other stimuli, such as growth factors, including endothelin-1 (ET-1), to promote malignant progression in numerous tumors.
Bagnato, Anna +6 more
core +1 more source
Hypoxia and HIF activation as a possible link between sepsis and thrombosis
Thrombosis Journal, 2019 Risk factors for thrombosis include hypoxia and sepsis, but the mechanisms that control sepsis-induced thrombus formation are incompletely understood.
Colin E. Evans
doaj +1 more source
HIF-1α, a novel piece in the NF-κB puzzle [PDF]
, 2015 Hypoxia, or low oxygen availability, is an important physiological stimulus for multicellular organisms. Molecularly, hypoxia induces a transcriptional programme directed at restoration of oxygen homeostasis and cellular survival.
Bandarra, Daniel, Rocha, Sonia
core +3 more sources
Therapeutic targeting of hypoxia and hypoxia-inducible factors in cancer.
Pharmacology and Therapeutics, 2016 Insufficient tissue oxygenation, or hypoxia, contributes to tumor aggressiveness and has a profound impact on clinical outcomes in cancer patients.
C. Wigerup, S. Påhlman, D. Bexell
semanticscholar +1 more source
The updated biology of hypoxia‐inducible factor [PDF]
The EMBO Journal, 2012 Oxygen is essential for eukaryotic life and is inextricably linked to the evolution of multicellular organisms. Proper cellular response to changes in oxygen tension during normal development or pathological processes, such as cardiovascular disease and cancer, is ultimately regulated by the transcription factor, hypoxia-inducible factor (HIF).
Samantha N, Greer +3 more
openaire +2 more sources