Results 61 to 70 of about 1,344,802 (358)

Gene and protein expression of glucose transporter 1 and glucose transporter 3 in human laryngeal cancer—the relationship with regulatory hypoxia-inducible factor-1α expression, tumor invasiveness, and patient prognosis [PDF]

, 2014
Increased glucose uptake mediated by glucose transporters and reliance on glycolysis are common features of malignant cells. Hypoxia-inducible factor-1α supports the adaptation of hypoxic cells by inducing genes related to glucose metabolism.
Anna Krześlak, AP Demasi, AW Eckert, AW Eckert, BW Kim, C Zhang, CM Douglas, DE Burstein, DW Li, E Cadman, Ewa Brzezińska-Błaszczyk, Ewa Forma, FR Ayala, GL Semenza, H Kaida, H Kaida, Iwona Lewy-Trenda, J Xie, JL Roh, JL Thorne, K Müssig, K Starska, Katarzyna Starska, L Lan, L Zhang, M Kobayashi, M Mueckler, M Shimanishi, Magdalena Bryś, ML Schrijvers, O Koperek, OJ Kwon, Paweł Jóźwiak, R Cabanillas, R Ciampi, R Rashmi, S Kondo, S Ohba, S Zhou, SB Edge, SW Jing, SX Yan, T Yamada, W Fenske, W Ping, X Zhang, XH Chen, XH Wu, XP Sun, Y Cui, Y Kondo, YY Xu   +51 more
core   +1 more source

Human activated macrophages and hypoxia: a comprehensive review of the literature [PDF]

Iranian Journal of Basic Medical Sciences, 2014
Macrophages accumulate in poorly vascularised and hypoxic sites including solid tumours, wounds and sites of infection and inflammation where they can be exposed to low levels of oxygen for long periods.
Fattah Sotoodehnejadnematalahi, Bernard Burke   +1 more
doaj  

mRNA expression profile of selected oxygen sensing genes in the lung during recovery from chronic hypoxia

Biological Research, 2013
This study analyzed the time dependence decay of the mRNA of selected genes important for the hypoxia response. The genes chosen were the two isoforms of hypoxia-inducible factors, the three isoforms of the prolyl hydroxylase domain protein, the vascular
Alice Panariti, Giuseppe Miserocchi, Ilaria Rivolta   +2 more
doaj   +1 more source

Hypoxia helps glioma to fight therapy [PDF]

, 2009
Despite major improvements in the surgical management the prognosis for patients bearing malignant gliomas is still dismal. Malignant gliomas are notoriously resistant to treatment and the survival time of patients is between 3-8 years for low-grade and
Amberger-Murphy, Verena
core   +1 more source

One special question to start with: can HIF/NFkB be a target in inflammation? [PDF]

, 2015
Hypoxia and Inflammation are strictly interconnected with important consequences at clinical and therapeutic level. While cell and tissue damage due to acute hypoxia mostly leads to cell necrosis, in chronic hypoxia, cells that are located closer to ...
CARNEVALE, ILARIA, DE SANTIS, Elena, Limana, F, Perrone, Ga, POLLETTA, LUCIA, RUNCI, ALESSANDRA, RUSSO, Matteo Antonio, SANSONE, LUIGI, TAFANI, MARCO   +8 more
core   +1 more source

Endocrine targets of hypoxia-inducible factors [PDF]

Journal of Endocrinology, 2017
Endocrine is an important and tightly regulated system for maintaining body homeostasis. Endocrine glands produce hormones, which are released into blood stream to guide the target cells responding to all sorts of stimulations. For maintaining body homeostasis, the secretion and activity of a particular hormone needs to be adjusted in responding to ...
Hsiu-Chi, Lee, Shaw-Jenq, Tsai
openaire   +2 more sources

Ferroptosis Regulated by Hypoxia in Cells

Cells, 2023
Ferroptosis is an oxidative damage-related, iron-dependent regulated cell death with intracellular lipid peroxide accumulation, which is associated with many physiological and pathological processes.
Xiangnan Zheng, Yuqiong Liang, Cen Zhang
doaj   +1 more source

An expression signature of the angiogenic response in gastrointestinal neuroendocrine tumours: correlation with tumour phenotype and survival outcomes. [PDF]

, 2013
BACKGROUND: Gastroenteropancreatic neuroendocrine tumours (GEP-NETs) are heterogeneous with respect to biological behaviour and prognosis. As angiogenesis is a renowned pathogenic hallmark as well as a therapeutic target, we aimed to investigate the ...
A Couvelard, A Giatromanolaki, A Rinke, AM Marion-Audibert, AT Dimou, B Terris, D Hanahan, D J Pinato, D O’Toole, DC Metz, DJ Pinato, DJ Pinato, E Raymond, EP Hui, F Panzuto, G Kloppel, HS Kim, I Albrecht, IM Modlin, J LeCouter, J Strosberg, J Zhang, JC Yao, JT Chi, JY Scoazec, K Hirabayashi, K Meeran, K Villaume, M Dal Monte, M Perigny, M Ruscica, MA Maynard, N Martin, N Ngo, P Kuiper, R Dina, R Katoh, R Mentlein, R Ramachandran, R Sharma, S Ezziddin, S T K Toussi, T M Tan, VD Corleto, Y Arvidsson, Y Seo, Y Takahashi, YC Patel   +47 more
core   +2 more sources

Inhibition of vascular endothelial growth factor with a sequence-specific hypoxia response element antagonist [PDF]

, 2004
Vascular endothelial growth factor (VEGF) and its receptors have been implicated as key factors in tumor angiogenesis that are up-regulated by hypoxia. We evaluated the effects of DNA-binding small molecules on hypoxia-inducible transcription of VEGF.
Dervan, Peter B., Kaelin, William G., Jr., Klco, Jeffery M., Nickols, Nicholas G., Olenyuk, Bogdan Z., Zhang, Guo-Jun   +5 more
core  

Integration of circadian and hypoxia signaling via non‐canonical heterodimerization

FEBS Letters, EarlyView.
CLOCK, BMAL1, and HIFs are basic helix‐loop‐helix and Per‐Arnt‐Sim domain (bHLH‐PAS) proteins, which function as transcription factors. bHLH‐PAS proteins are designated in two classes. Many class I proteins are regulated by environmental signals via their PAS domains, but such signals have not been identified for all.
Sicong Wang, Katja A. Lamia
wiley   +1 more source