Results 61 to 70 of about 1,301,346 (361)
The role of hypoxia-inducible factors in tumorigenesis [PDF]
Cell Death & Differentiation, 2008 Hypoxia-inducible factors (HIFs) are essential mediators of the cellular oxygen-signaling pathway. They are heterodimeric transcription factors consisting of an oxygen-sensitive alpha subunit (HIF-alpha) and a constitutive beta subunit (HIF-beta) that facilitate both oxygen delivery and adaptation to oxygen deprivation by regulating the expression of ...
Erinn B. Rankin, Amato J. Giaccia
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Human activated macrophages and hypoxia: a comprehensive review of the literature [PDF]
Iranian Journal of Basic Medical Sciences, 2014 Macrophages accumulate in poorly vascularised and hypoxic sites including solid tumours, wounds and sites of infection and inflammation where they can be exposed to low levels of oxygen for long periods.
Fattah Sotoodehnejadnematalahi +1 more
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Allogeneic mesenchymal stromal cells overexpressing mutant human Hypoxia-inducible factor 1-α (HIF1-α) in an ovine model of acute myocardial infarction [PDF]
, 2016 Background-Bone marrow mesenchymal stromal cells (BMMSCs) are cardioprotective in acute myocardial infarction (AMI) because of release of paracrine angiogenic and prosurvival factors.
Crottogini, Alberto José +11 more
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Ferroptosis Regulated by Hypoxia in Cells
Cells, 2023 Ferroptosis is an oxidative damage-related, iron-dependent regulated cell death with intracellular lipid peroxide accumulation, which is associated with many physiological and pathological processes.
Xiangnan Zheng, Yuqiong Liang, Cen Zhang
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Maintenance of redox homeostasis by hypoxia-inducible factors
Redox Biology, 2017 Oxidative phosphorylation enables cells to generate the large amounts of ATP required for development and maintenance of multicellular organisms. However, under conditions of reduced O2 availability, electron transport becomes less efficient, leading to ...
Debangshu Samanta, Gregg L. Semenza
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Hypoxia helps glioma to fight therapy [PDF]
, 2009 Despite major improvements in the surgical management the prognosis for patients bearing malignant gliomas is still dismal. Malignant gliomas are notoriously resistant to treatment and the survival time of patients is between 3-8 years for low-grade and
Amberger-Murphy, Verena
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Autophagy degrades hypoxia inducible factors [PDF]
Molecular & Cellular Oncology, 2016 Hypoxia inducible factors are subjected to degradation by the ubiquitin-proteasome system (UPS), macroautophagy, and chaperone-mediated autophagy. The E3 ligases, ubiquitination, autophagy receptor proteins, and oxygen are determinants that direct hypoxia-inducible factors to different degradation pathways.
Xian De Liu, Eric Jonasch, Adela DePavia
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Frontiers in Physiology, 2022 Cases of coronavirus disease 2019 (COVID-19) have been reported worldwide. However, one epidemiological report has claimed a lower incidence of the disease in people living at high altitude (>2,500 m), proposing the hypothesis that adaptation to ...
Christian Albert Devaux +4 more
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One special question to start with: can HIF/NFkB be a target in inflammation? [PDF]
, 2015 Hypoxia and Inflammation are strictly interconnected with important consequences at clinical and therapeutic level. While cell and tissue damage due to acute hypoxia mostly leads to cell necrosis, in chronic hypoxia, cells that are located closer to ...
CARNEVALE, ILARIA +8 more
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Hypoxia Inducible Factor-2α in Cancer [PDF]
Cell Cycle, 2007 Poorly oxygenated (hypoxic) tumors are frequently more aggressive compared to corresponding tumors that are better oxygenated. Adaptation to hypoxia is primarily mediated by two closely related hypoxia inducible transcription factor complexes, HIF-1 and HIF-2, which become stabilized and activated at low oxygen levels.
Lorenz Poellinger +6 more
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