Results 31 to 40 of about 216,063 (137)

The effects of levosimendan on brain metabolism during initial recovery from global transient ischaemia/hypoxia

BMC Neurology, 2012
Backround Neuroprotective strategies after cardiopulmonary resuscitation are currently the focus of experimental and clinical research. Levosimendan has been proposed as a promising drug candidate because of its cardioprotective properties, improved ...
Roehl Anna B, Zoremba Norbert, Kipp Markus, Schiefer Johannes, Goetzenich Andreas, Bleilevens Christian, Kuehn-Velten Nikolaus, Tolba Rene, Rossaint Rolf, Hein Marc   +9 more
doaj   +1 more source

Bioactivity of Inhaled Methane and Interactions With Other Biological Gases

Frontiers in Cell and Developmental Biology, 2022
A number of studies have demonstrated explicit bioactivity for exogenous methane (CH4), even though it is conventionally considered as physiologically inert. Other reports cited in this review have demonstrated that inhaled, normoxic air-CH4 mixtures can
László Juhász, Szabolcs Péter Tallósy, Anna Nászai, Gabriella Varga, Dániel Érces, Mihály Boros   +5 more
doaj   +1 more source

Hypoxia-Inducible Factor 1 Protects Hypoxic Astrocytes against Glutamate Toxicity

ASN Neuro, 2012
Stroke is a major neurological disorder characterized by an increase in the Glu (glutamate) concentration resulting in excitotoxicity and eventually cellular damage and death in the brain. HIF-1 (hypoxia-inducible factor-1), a transcription factor, plays
Yomna Badawi, Prabhu Ramamoorthy, glian Shi   +2 more
doaj   +1 more source

BH4 supplementation reduces retinal cell death in ischaemic retinopathy

Scientific Reports, 2023
Dysregulation of nitric oxide (NO) production can cause ischaemic retinal injury and result in blindness. How this dysregulation occurs is poorly understood but thought to be due to an impairment in NO synthase function (NOS) and nitro-oxidative stress ...
Kevin S. Edgar, Ciara Cunning, Tom A. Gardiner, Denise M. McDonald   +3 more
doaj   +1 more source

HIF-1alpha and HIF-2alpha are differentially activated in distinct cell populations in retinal ischaemia.

PLoS ONE, 2010
BackgroundHypoxia plays a key role in ischaemic and neovascular disorders of the retina. Cellular responses to oxygen are mediated by hypoxia-inducible transcription factors (HIFs) that are stabilised in hypoxia and induce the expression of a diverse ...
Freya M Mowat, Ulrich F O Luhmann, Alexander J Smith, Clemens Lange, Yanai Duran, Sarah Harten, Deepa Shukla, Patrick H Maxwell, Robin R Ali, James W B Bainbridge   +9 more
doaj   +1 more source

Generalized dystonia following resuscitation from a cardiac arrest: a case report and review of the literature

The Egyptian Journal of Neurology, Psychiatry and Neurosurgery, 2023
Background A wide variety of movement disorders can be observed after cerebral hypoxia, including akineto-hypertonic syndrome and dystonia. Post-anoxic dystonia is a rare clinical syndrome that is not widely reported in the literatures.
Ahmadou Bamba Mbodji, Maouly Fall, Ndiaga Matar Gaye, Mamadou Ka, Jean Claude Dione, Moustapha Ndiaye, Amadou Gallo Diop   +6 more
doaj   +1 more source

Role of hypoxic exosomes and the mechanisms of exosome release in the CNS under hypoxic conditions

Frontiers in Neurology, 2023
Hypoxia is characterized by low oxygen levels in the body or environment, resulting in various physiological and pathological changes. The brain, which has the highest oxygen consumption of any organ, is particularly susceptible to hypoxic injury ...
Rong Yang, Rong Yang, Zheng Li, Zheng Li, Jing Xu, Jing Xu, Juan Luo, Juan Luo, Zhichuang Qu, Zhichuang Qu, Xin Chen, Xin Chen, Sixun Yu, Sixun Yu, Haifeng Shu, Haifeng Shu, Haifeng Shu   +16 more
doaj   +1 more source

Protective Effects of GYY4137 on Renal Ischaemia/Reperfusion Injury through Nrf2-Mediated Antioxidant Defence

Kidney & Blood Pressure Research, 2021
Introduction/Aims: Hydrogen sulfide (H2S) is considered to be the third most important endogenous gasotransmitter in organisms. GYY4137 is a long-acting donor for H2S, a gas transmitter that has been shown to prevent multi-organ damage in animal studies.
Hongmei Zhao, Yun Qiu, Yichen Wu, Hong Sun, Sumin Gao   +4 more
doaj   +1 more source

First trimester maternal serum ischaemia-modified albumin: A marker of hypoxia-ischaemia-driven early trophoblast development

, 2007
BACKGROUND A hypoxic intrauterine environment is believed to play a pivotal role in physiological trophoblast development. Ischaemia-modified albumin (IMA) is used in the measurement of cardiac ischaemia.
Thilaganathan, Baskaran, Thilaganathan, B., Collinson, P.O., Gaze, David C., Gaze, D.C., Papageorghiou, Aris T., Papageorghiou, A. T., Prefumo, Federico, Prefumo, F., Collinson, Paul O.   +9 more
core   +1 more source

Incidence and clinical analysis of asymptomatic intracranial hemorrhage in neonates with cerebral hypoxic-ischaemic risk based on multisequence MR images

Scientific Reports
The incidence and clinical distribution of intracranial haemorrhage (ICH) in neonates at risk of cerebral hypoxia–ischaemia have not been reported in specific studies.
Qi Xie, Yan-Hui Liao, Wen-juan He, Gui-Qin Wang   +3 more
doaj   +1 more source