Results 31 to 40 of about 44,731 (245)

BH4 supplementation reduces retinal cell death in ischaemic retinopathy

Scientific Reports, 2023
Dysregulation of nitric oxide (NO) production can cause ischaemic retinal injury and result in blindness. How this dysregulation occurs is poorly understood but thought to be due to an impairment in NO synthase function (NOS) and nitro-oxidative stress ...
Kevin S. Edgar, Ciara Cunning, Tom A. Gardiner, Denise M. McDonald   +3 more
doaj   +1 more source

Hypoxia-Inducible Factor 1 Protects Hypoxic Astrocytes against Glutamate Toxicity

ASN Neuro, 2012
Stroke is a major neurological disorder characterized by an increase in the Glu (glutamate) concentration resulting in excitotoxicity and eventually cellular damage and death in the brain. HIF-1 (hypoxia-inducible factor-1), a transcription factor, plays
Yomna Badawi, Prabhu Ramamoorthy, glian Shi   +2 more
doaj   +1 more source

Generalized dystonia following resuscitation from a cardiac arrest: a case report and review of the literature

The Egyptian Journal of Neurology, Psychiatry and Neurosurgery, 2023
Background A wide variety of movement disorders can be observed after cerebral hypoxia, including akineto-hypertonic syndrome and dystonia. Post-anoxic dystonia is a rare clinical syndrome that is not widely reported in the literatures.
Ahmadou Bamba Mbodji, Maouly Fall, Ndiaga Matar Gaye, Mamadou Ka, Jean Claude Dione, Moustapha Ndiaye, Amadou Gallo Diop   +6 more
doaj   +1 more source

HIF-1alpha and HIF-2alpha are differentially activated in distinct cell populations in retinal ischaemia.

PLoS ONE, 2010
BackgroundHypoxia plays a key role in ischaemic and neovascular disorders of the retina. Cellular responses to oxygen are mediated by hypoxia-inducible transcription factors (HIFs) that are stabilised in hypoxia and induce the expression of a diverse ...
Freya M Mowat, Ulrich F O Luhmann, Alexander J Smith, Clemens Lange, Yanai Duran, Sarah Harten, Deepa Shukla, Patrick H Maxwell, Robin R Ali, James W B Bainbridge   +9 more
doaj   +1 more source

Caffeine Citrate does not reduce brain injury following inflammation-amplified hypoxia ischaemia or hypoxia ischaemia in the Newborn Piglet Model

Neuropharmacology
There is a need to develop alternative therapies for neonatal encephalopathy (NE) in term babies. Caffeine citrate exposure saw benefit in preclinical models of hypoxia-ischaemia (HI). We assessed the safety and cytoprotective efficacy of caffeine citrate in an inflammation-amplified (IA-HI) and HI newborn piglet model based on the probability of ...
George Maple, Christopher Meehan, Ilenia d’Angelo, Yujin Kim, Ellie Campbell, Katie Tucker, Kennosuke Tsuda, Louise Han, Georgina Norris, Alison Mintoft, Francisco Torrealdea, Alan Bainbridge, John Barks, Raymand Pang, Nicola J. Robertson   +14 more
openaire   +2 more sources

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Normal‐Appearing White Matter Injury Mediates Chronic Deep Venous Hypoxia and Disease Progression in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore how cerebral hypoxia and Normal‐Appearing White Matter (NAWM) integrity affect MS lesion burden and clinical course. Methods Seventy‐nine MS patients, including 13 clinically isolated syndrome (CIS) patients and 66 relapsing–remitting multiple sclerosis (RRMS) patients, and 44 healthy controls (HCs) were recruited from ...
Xinli Wang, Huiying Wang, Zhizheng Zhuo, Ai Guo, Ke Lv, Decai Tian, Chao Chai, Yunyun Duan, Shuang Xia   +8 more
wiley   +1 more source

Role of hypoxic exosomes and the mechanisms of exosome release in the CNS under hypoxic conditions

Frontiers in Neurology, 2023
Hypoxia is characterized by low oxygen levels in the body or environment, resulting in various physiological and pathological changes. The brain, which has the highest oxygen consumption of any organ, is particularly susceptible to hypoxic injury ...
Rong Yang, Rong Yang, Zheng Li, Zheng Li, Jing Xu, Jing Xu, Juan Luo, Juan Luo, Zhichuang Qu, Zhichuang Qu, Xin Chen, Xin Chen, Sixun Yu, Sixun Yu, Haifeng Shu, Haifeng Shu, Haifeng Shu   +16 more
doaj   +1 more source

Added Prognostic Value of EEG Reactivity in Comatose Patients Following Cardiac Arrest

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives To evaluate the added prognostic value of EEG reactivity for favorable outcome compared with background analysis during and after targeted temperature management (TTM). Methods Prospective observational cohort study of comatose post–cardiac arrest patients admitted to a single academic center between 2017 and 2022, all undergoing ...
Sarah Caroyer, Marie Obrecht, Charlotte de Maeseneire, Charlotte Damien, Chantal Depondt, Lorenzo Ferlini, Estelle Rikir, Filippo Annoni, Fabio Silvio Taccone, Nicolas Mavroudakis, Benjamin Legros, Nicolas Gaspard   +11 more
wiley   +1 more source

Protective Effects of GYY4137 on Renal Ischaemia/Reperfusion Injury through Nrf2-Mediated Antioxidant Defence

Kidney & Blood Pressure Research, 2021
Introduction/Aims: Hydrogen sulfide (H2S) is considered to be the third most important endogenous gasotransmitter in organisms. GYY4137 is a long-acting donor for H2S, a gas transmitter that has been shown to prevent multi-organ damage in animal studies.
Hongmei Zhao, Yun Qiu, Yichen Wu, Hong Sun, Sumin Gao   +4 more
doaj   +1 more source