Results 11 to 20 of about 44,731 (245)

Impact of neonatal hypoxia-ischaemia on oligodendrocyte survival, maturation and myelinating potential. [PDF]

J Cell Mol Med, 2018
AbstractHypoxic‐ischaemic episodes experienced at the perinatal period commonly lead to a development of neurological disabilities and cognitive impairments in neonates or later in childhood. Clinical symptoms often are associated with the observed alterations in white matter in the brains of diseased children, suggesting contribution of triggered ...
Ziemka-Nalecz M, Janowska J, Strojek L, Jaworska J, Zalewska T, Frontczak-Baniewicz M, Sypecka J.   +6 more
europepmc   +3 more sources

Ongoing loss of viable neurons for weeks after mild hypoxia-ischaemia. [PDF]

Brain Commun
Abstract Mild hypoxic-ischaemic encephalopathy is common in neonates, and there are no evidence-based therapies. By school age, 30–40% of those patients experience adverse neurodevelopmental outcomes. The nature and progression of mild injury is poorly understood. We studied the evolution of mild perinatal brain injury using longitudinal
McNally MA, Lau LA, Granak S, Hike D, Liu X, Yu X, Donahue RA, Chibnik LB, Ortiz JV, Che A, Chavez-Valdez R, Northington FJ, Staley KJ.   +12 more
europepmc   +3 more sources

EFFECTS OF LEFLUNOMIDE TREATMENT ON NEURAL CELLS IN A MODEL OF HYPOXIA ISCHAEMIA

IBRO Neuroscience Reports, 2023
Claire Curel, Claire Thornton
doaj   +2 more sources

Defining a Time Window for Neuroprotection and Glia Modulation by Caffeine After Neonatal Hypoxia-Ischaemia. [PDF]

Mol Neurobiol, 2020
AbstractHypoxic-ischemic (HI) brain injury remains an important cause of brain damage in neonates with potential life-long consequences. Caffeine, which is a competitive inhibitor of adenosine receptors, is commonly used as treatment for preterm apnoea in clinical settings. In the current study, we investigated the effects of caffeine given at 0 h, 6 h,
Di Martino E, Bocchetta E, Tsuji S, Mukai T, Harris RA, Blomgren K, Ådén U.   +6 more
europepmc   +4 more sources

Early Plasma Magnesium in Near-Term and Term Infants with Neonatal Encephalopathy in the Context of Perinatal Asphyxia

Children, 2022
Magnesium ions are implicated in brain functioning. The disruption of brain metabolism subsequent to a perinatal hypoxic-ischaemic insult may be reflected by plasma magnesium.
Juliette Suhard, Cathie Faussat, Baptiste Morel, Emeline Laurent, Geraldine Favrais   +4 more
doaj   +1 more source

Fetal hypoxia‐ischaemia: wrong time, wrong place [PDF]

Developmental Medicine & Child Neurology, 2019
This commentary is on the invited review by Baxter on pages 563–568 of this issue.
openaire   +3 more sources

Dysmaturation of sleep state and electroencephalographic activity after hypoxia-ischaemia in preterm fetal sheep. [PDF]

J Cereb Blood Flow Metab
Antenatal hypoxia-ischaemia (HI) in preterm fetal sheep can trigger delayed evolution of severe, cystic white matter injury (WMI), in a similar timecourse to WMI in preterm infants. We therefore examined how severe hypoxia-ischaemia affects recovery of electroencephalographic (EEG) activity.
Lear CA, Lear BA, Davidson JO, King VJ, Maeda Y, McDouall A, Dhillon SK, Gunn AJ, Bennet L.   +8 more
europepmc   +3 more sources

The Role of Mitochondria in Brain Cell Protection from Ischaemia by Differently Prepared Propolis Extracts

Antioxidants, 2020
Mitochondria are both the primary targets and mediators of ischaemic damage in brain cells. Insufficient oxygen causes reactive oxygen species that damage the mitochondria, leading to the loss of functionality and viability of highly energy-demanding ...
Zbigniev Balion, Kristina Ramanauskienė, Aistė Jekabsone, Daiva Majienė   +3 more
doaj   +1 more source

Hypoxic mesenchymal stem cell-derived exosomes promote the survival of skin flaps after ischaemia–reperfusion injury via mTOR/ULK1/FUNDC1 pathways

Journal of Nanobiotechnology, 2023
Flap necrosis, the most prevalent postoperative complication of reconstructive surgery, is significantly associated with ischaemia–reperfusion injury. Recent research indicates that exosomes derived from bone marrow mesenchymal stem cells (BMSCs) hold ...
Chao Deng, Kangkang Dong, Yongjun Liu, Ken Chen, Chuwei Min, Zheming Cao, Panfeng Wu, Gaojie Luo, Gechang Cheng, Liming Qing, Juyu Tang   +10 more
doaj   +1 more source

Pre-Conditioning with CDP-Choline Attenuates Oxidative Stress-Induced Cardiac Myocyte Death in a Hypoxia/Reperfusion Model

The Scientific World Journal, 2014
Background. CDP-choline is a key intermediate in the biosynthesis of phosphatidylcholine, which is an essential component of cellular membranes, and a cell signalling mediator.
Héctor González-Pacheco, Aurelio Méndez-Domínguez, Salomón Hernández, Rebeca López-Marure, Maria J. Vazquez-Mellado, Cecilia Aguilar, Leticia Rocha-Zavaleta   +6 more
doaj   +1 more source