Results 11 to 20 of about 216,063 (137)

Endothelin and the ischaemic heart [PDF]

, 2005
Soon after its identification as a powerful vasoconstrictor peptide, endothelin (ET-1) was implicated as a detrimental agent involved in determining the outcome of myocardial ischaemia and reperfusion.
McCabe, C., Kane, K.A., Wainwright, C.L.
core   +8 more sources

The effects of hyperglycaemic hypoxia on rectification in rat dorsal root axons [PDF]

, 1994
1. Electrotonic responses to 150 ms current pulses were recorded from isolated rat dorsal roots incubated for at least 3 h with either normal (5 mM) or high (25 mM) D-glucose solutions, and with either normal (25 mM) or low (5 mM) bicarbonate ...
U Schneider, H Bostock, Schneider, Uwe, Grafe, Peter, Bostock, Hugh, P Grafe   +5 more
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Delayed hypothermia prevents decreases in N-acetylaspartate and reduced glutathione in the cerebral cortex of the neonatal pig following transient hypoxia-ischaemia

, 2013
The effects of normothermia and delayed hypothermia on the levels of N-acetylaspartate (NAA), reduced glutathione (GSH) and the activities of mitochondrial complex I, II-III, IV and citrate synthase were measured in brain homogenates obtained from ...
Martina Noone (17251171), Yasuko Sakata (17251177), Ernest Cady (17251159), Keith J Brooks (17251165), Francis O'Brien (17251162), Iain Hargreaves (49266), Roger Ordidge (17185633), Quyen Nguyen (1312230), Matthew Clemence (17251174), Timothy Bates (17153641), John Thornton (539603), John Wyatt (233278), Kishore Bhakoo (7552550), Mark Sellwood (17251168), Marzena Wylezinska (2609704)   +14 more
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Is resistance to ischaemia of motor axons in diabetic subjects due to membrane depolarization? [PDF]

, 1990
The reasons for the resistance to ischaemia of peripheral nerves in diabetics are not well understood. We have now explored whether axonal depolarization underlies this phenomenon, as has previously been proposed.
Weigl, Paul, Piwernetz, Klaus, Strupp, Michael, Bostock, Hugh, Grafe, Peter, Renner, Rolf   +5 more
core   +1 more source

Upregulation of cardioprotective SUR2A by sub-hypoxic drop in oxygen [PDF]

, 2014
The effects of hypoxia on gene expression have been vigorously studied, but possible effects of small changes in oxygen tension have never been addressed.
Sukhodub, Andriy, Mohammed Abdul, Khaja Shameem, Du, Qingyou, Jovanovic, Aleksandar, Khaja Shameem Mohammed Abdul, Sofija Jovanović, Jovanovic, Sofija, Aleksandar Jovanović, Andriy Sukhodub, Qingyou Du   +9 more
core   +1 more source

Do K_ATP channels open as a prominent and early feature during ischaemia in the Langendorff-perfused rat heart? [PDF]

, 2000
The objective was to investigate whether myocardial adenosine triphosphate-sensitive K⁺ (K_ATP) channels open during the first 10 min of regional ischaemia in Langendorff-perfused rat hearts.
Northover, B.J., MacKenzie, I., Workman, A.J.   +2 more
core   +1 more source

Hypoxia-induced alternative splicing in endothelial cells [PDF]

, 2012
Background: Adaptation to low oxygen by changing gene expression is vitally important for cell survival and tissue development. The sprouting of new blood vessels, initiated from endothelial cells, restores the oxygen supply of ischemic tissues.
Weigand, Julia E., Julia E. Weigand (17017), Julia E Weigand, Pascal Gellert, Stefanie Dimmeler, Dimmeler, Stefanie, Jes-Niels Boeckel (145707), Pascal Gellert (145710), Gellert, Pascal, Jes-Niels Boeckel, Stefanie Dimmeler (134234), Boeckel, Jes-Niels   +11 more
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A depletable pool of adenosine in area CA1 of the rat hippocampus [PDF]

, 2001
Adenosine plays a major modulatory and neuroprotective role in the mammalian CNS. During cerebral metabolic stress, such as hypoxia or ischemia, the increase in extracellular adenosine inhibits excitatory synaptic transmission onto vulnerable neurons via
Darren Caldwell, Caldwell, Darren, Feruza Nuritova, Bruno G. Frenguelli, Dale, Nicholas, Pearson, Tim, Nuritova, Feruza, Frenguelli, Bruno G., Tim Pearson, Nicholas Dale   +9 more
core   +1 more source

Early Plasma Magnesium in Near-Term and Term Infants with Neonatal Encephalopathy in the Context of Perinatal Asphyxia

Children, 2022
Magnesium ions are implicated in brain functioning. The disruption of brain metabolism subsequent to a perinatal hypoxic-ischaemic insult may be reflected by plasma magnesium.
Juliette Suhard, Cathie Faussat, Baptiste Morel, Emeline Laurent, Geraldine Favrais   +4 more
doaj   +1 more source

The Role of Mitochondria in Brain Cell Protection from Ischaemia by Differently Prepared Propolis Extracts

Antioxidants, 2020
Mitochondria are both the primary targets and mediators of ischaemic damage in brain cells. Insufficient oxygen causes reactive oxygen species that damage the mitochondria, leading to the loss of functionality and viability of highly energy-demanding ...
Zbigniev Balion, Kristina Ramanauskienė, Aistė Jekabsone, Daiva Majienė   +3 more
doaj   +1 more source