Results 21 to 30 of about 216,063 (137)

Pre-Conditioning with CDP-Choline Attenuates Oxidative Stress-Induced Cardiac Myocyte Death in a Hypoxia/Reperfusion Model

The Scientific World Journal, 2014
Background. CDP-choline is a key intermediate in the biosynthesis of phosphatidylcholine, which is an essential component of cellular membranes, and a cell signalling mediator.
Héctor González-Pacheco, Aurelio Méndez-Domínguez, Salomón Hernández, Rebeca López-Marure, Maria J. Vazquez-Mellado, Cecilia Aguilar, Leticia Rocha-Zavaleta   +6 more
doaj   +1 more source

Regulation of Nrf2/Keap1 signalling in human skeletal muscle during exercise to exhaustion in normoxia, severe acute hypoxia and post-exercise ischaemia: Influence of metabolite accumulation and oxygenation

Redox Biology, 2020
The Nrf2 transcription factor is induced by reactive oxygen and nitrogen species and is necessary for the adaptive response to exercise in mice. It remains unknown whether Nrf2 signalling is activated by exercise in human skeletal muscle.
Angel Gallego-Selles, Marcos Martin-Rincon, Miriam Martinez-Canton, Mario Perez-Valera, Saúl Martín-Rodríguez, Miriam Gelabert-Rebato, Alfredo Santana, David Morales-Alamo, Cecilia Dorado, Jose A.L. Calbet   +9 more
doaj   +1 more source

Hypoxia-induced signaling in angiogenesis : role of mTOR, HIF and Angiotensin II [PDF]

, 2007
This thesis includes the work of four different projects I have been following during my time as a PhD student; (1) the characterization of mTOR-associated signaling and endothelial cell proliferation in response to hypoxia, and (2) identification of ...
Petrimpol, Marco Renato
core   +1 more source

Hypoxic mesenchymal stem cell-derived exosomes promote the survival of skin flaps after ischaemia–reperfusion injury via mTOR/ULK1/FUNDC1 pathways

Journal of Nanobiotechnology, 2023
Flap necrosis, the most prevalent postoperative complication of reconstructive surgery, is significantly associated with ischaemia–reperfusion injury. Recent research indicates that exosomes derived from bone marrow mesenchymal stem cells (BMSCs) hold ...
Chao Deng, Kangkang Dong, Yongjun Liu, Ken Chen, Chuwei Min, Zheming Cao, Panfeng Wu, Gaojie Luo, Gechang Cheng, Liming Qing, Juyu Tang   +10 more
doaj   +1 more source

Pancreatic Islet Viability Assessment Using Hyperspectral Imaging of Autofluorescence

Cells, 2023
Islets prepared for transplantation into type 1 diabetes patients are exposed to compromising intrinsic and extrinsic factors that contribute to early graft failure, necessitating repeated islet infusions for clinical insulin independence.
Jared M. Campbell, Stacey N. Walters, Abbas Habibalahi, Saabah B. Mahbub, Ayad G. Anwer, Shannon Handley, Shane T. Grey, Ewa M. Goldys   +7 more
doaj   +1 more source

Hypoxic regulation of hand1 controls the fetal-neonatal switch in cardiac metabolism.

PLoS Biology, 2013
Cardiomyocytes are vulnerable to hypoxia in the adult, but adapted to hypoxia in utero. Current understanding of endogenous cardiac oxygen sensing pathways is limited.
Ross A Breckenridge, Izabela Piotrowska, Keat-Eng Ng, Timothy J Ragan, James A West, Surendra Kotecha, Norma Towers, Michael Bennett, Petra C Kienesberger, Ryszard T Smolenski, Hillary K Siddall, John L Offer, Mihaela M Mocanu, Derek M Yelon, Jason R B Dyck, Jules L Griffin, Andrey Y Abramov, Alex P Gould, Timothy J Mohun   +18 more
doaj   +1 more source

Echocardiographic and ultrasound evaluation of haemodynamic parameters in hypoxic neonates treated with hypothermia: Study protocol

Frontiers in Pediatrics, 2023
BackgroundEpisodes of ischaemia-hypoxia in the perinatal period as well as the changes in the redistribution of blood may lead to decreased perfusion and ischaemia of the cardiac muscle.
Natalia Brunets, Veronika Brunets, Renata Bokiniec   +2 more
doaj   +1 more source

Slowing of electrical activity in ventricular fibrillation is not associated with increased defibrillation energies in the isolated rabbit heart

Frontiers in Physiology, 2011
Prolonged out-of-hospital ventricular fibrillation (VF) arrests are associated with reduced ECG dominant frequency (DF) and diminished defibrillation success. Partial reversal of ischaemia increases ECG DF and improves defibrillation outcome.
Jane eCaldwell, Francis eBurton, Stuart eCobbe, Godfrey eSmith   +3 more
doaj   +1 more source

Ischaemic Markers in Acute Hepatic Injury [PDF]

Journal of Clinical and Diagnostic Research, 2016
Introduction: Hepatic injury of varied aetiology may progress to Acute Liver Failure (ALF). Compromised microcirculation is thought to be a deciding factor of hepatic hypoxia may be involved in disease progression that needs early detection ...
SUCHISMITA PANDA, SUSHANTA KUMAR JENA, RACHITA NANDA, MANASWINI MANGARAJ, PARSURAM NAYAK   +4 more
doaj   +1 more source

Review: Therapeutic applications of hypothermia in cerebral ischaemia

Therapeutic Advances in Neurological Disorders, 2008
There is considerable experimental evidence that hypothermia is neuroprotective and can reduce the severity of brain damage after global or focal cerebral ischaemia.
Bruno P. Meloni, Frank L. Mastaglia, Neville W. Knuckey   +2 more
doaj   +1 more source