Results 21 to 30 of about 44,731 (245)

Regulation of Nrf2/Keap1 signalling in human skeletal muscle during exercise to exhaustion in normoxia, severe acute hypoxia and post-exercise ischaemia: Influence of metabolite accumulation and oxygenation

open access: yesRedox Biology, 2020
The Nrf2 transcription factor is induced by reactive oxygen and nitrogen species and is necessary for the adaptive response to exercise in mice. It remains unknown whether Nrf2 signalling is activated by exercise in human skeletal muscle.
Angel Gallego-Selles   +9 more
doaj   +1 more source

Pancreatic Islet Viability Assessment Using Hyperspectral Imaging of Autofluorescence

open access: yesCells, 2023
Islets prepared for transplantation into type 1 diabetes patients are exposed to compromising intrinsic and extrinsic factors that contribute to early graft failure, necessitating repeated islet infusions for clinical insulin independence.
Jared M. Campbell   +7 more
doaj   +1 more source

Echocardiographic and ultrasound evaluation of haemodynamic parameters in hypoxic neonates treated with hypothermia: Study protocol

open access: yesFrontiers in Pediatrics, 2023
BackgroundEpisodes of ischaemia-hypoxia in the perinatal period as well as the changes in the redistribution of blood may lead to decreased perfusion and ischaemia of the cardiac muscle.
Natalia Brunets   +2 more
doaj   +1 more source

Hypoxic regulation of hand1 controls the fetal-neonatal switch in cardiac metabolism.

open access: yesPLoS Biology, 2013
Cardiomyocytes are vulnerable to hypoxia in the adult, but adapted to hypoxia in utero. Current understanding of endogenous cardiac oxygen sensing pathways is limited.
Ross A Breckenridge   +18 more
doaj   +1 more source

Slowing of electrical activity in ventricular fibrillation is not associated with increased defibrillation energies in the isolated rabbit heart

open access: yesFrontiers in Physiology, 2011
Prolonged out-of-hospital ventricular fibrillation (VF) arrests are associated with reduced ECG dominant frequency (DF) and diminished defibrillation success. Partial reversal of ischaemia increases ECG DF and improves defibrillation outcome.
Jane eCaldwell   +3 more
doaj   +1 more source

Ischaemic Markers in Acute Hepatic Injury [PDF]

open access: yesJournal of Clinical and Diagnostic Research, 2016
Introduction: Hepatic injury of varied aetiology may progress to Acute Liver Failure (ALF). Compromised microcirculation is thought to be a deciding factor of hepatic hypoxia may be involved in disease progression that needs early detection ...
SUCHISMITA PANDA   +4 more
doaj   +1 more source

Review: Therapeutic applications of hypothermia in cerebral ischaemia

open access: yesTherapeutic Advances in Neurological Disorders, 2008
There is considerable experimental evidence that hypothermia is neuroprotective and can reduce the severity of brain damage after global or focal cerebral ischaemia.
Bruno P. Meloni   +2 more
doaj   +1 more source

Bioactivity of Inhaled Methane and Interactions With Other Biological Gases

open access: yesFrontiers in Cell and Developmental Biology, 2022
A number of studies have demonstrated explicit bioactivity for exogenous methane (CH4), even though it is conventionally considered as physiologically inert. Other reports cited in this review have demonstrated that inhaled, normoxic air-CH4 mixtures can
László Juhász   +5 more
doaj   +1 more source

The effects of levosimendan on brain metabolism during initial recovery from global transient ischaemia/hypoxia

open access: yesBMC Neurology, 2012
Backround Neuroprotective strategies after cardiopulmonary resuscitation are currently the focus of experimental and clinical research. Levosimendan has been proposed as a promising drug candidate because of its cardioprotective properties, improved ...
Roehl Anna B   +9 more
doaj   +1 more source

Prediction of outcome following hypoxia/ischaemia in the human infant using cerebral impedance [PDF]

open access: yesClinical Neurophysiology, 2009
Changes in cerebral impedance in the newborn piglet are able to discriminate, within 1-2 h of acute hypoxia, between animals which will have a good neurological outcome, and those who have suffered more severe hypoxia resulting in poor outcome. The aim of this study was to determine if cerebral impedance could be used to identify those human infants ...
Lingwood, B.   +6 more
openaire   +6 more sources

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