Results 1 to 10 of about 44,582 (111)
Volume reduction of caudate nucleus is associated with movement coordination deficits in patients with hippocampal atrophy due to perinatal hypoxia-ischaemia [PDF]
NeuroImage: Clinical, 2020 Acute sentinel hypoxia-ischaemia in neonates can target the hippocampus, mammillary bodies, thalamus, and the basal ganglia. Our previous work with paediatric patients with a history of hypoxia-ischaemia has revealed hippocampal and diencephalic damage ...
Sharon Geva +2 more
exaly +4 more sources
Neonatal Hypoxia Ischaemia: Mechanisms, Models, and Therapeutic Challenges [PDF]
Frontiers in Cellular Neuroscience, 2017 Neonatal hypoxia-ischaemia (HI) is the most common cause of death and disability in human neonates, and is often associated with persistent motor, sensory, and cognitive impairment.
Lei Shi +2 more
exaly +4 more sources
Evidence of both foetal inflammation and hypoxia–ischaemia is associated with meconium aspiration syndrome [PDF]
Scientific Reports, 2021 Foetal hypoxia–ischaemia is a key trigger of meconium aspiration syndrome (MAS). However, many neonates develop MAS without evidence of hypoxia–ischaemia, suggesting the presence of covert but important risk variables. We evaluated the association of MAS
Kyoko Yokoi +5 more
doaj +2 more sources
Upregulation of Foxo3a protects neurons against hypoxia-ischaemia injury [PDF]
Archives of Medical Science, 2020 Introduction A series of transcription factors have been profiled in ischaemic stroke. Forkhead box protein O 3a (FoxO3a), which belongs to the family of transcription factors, is characterised by a forkhead DNA-binding domain.
Rongjia Lu +10 more
doaj +2 more sources
Efficacy of melatonin in term neonatal models of perinatal hypoxia‐ischaemia [PDF]
Annals of Clinical and Translational Neurology, 2022 Objective Neonatal encephalopathy (NE) is an important cause of mortality and disability worldwide. Therapeutic hypothermia (HT) is an effective therapy, however not all babies benefit. Novel agents are urgently needed to improve outcomes.
Raymand Pang +5 more
doaj +2 more sources
Haemodynamic Instability and Brain Injury in Neonates Exposed to Hypoxia–Ischaemia [PDF]
Brain Sciences, 2019 Brain injury in the asphyxic newborn infant may be exacerbated by delayed restoration of cardiac output and oxygen delivery. With increasing severity of asphyxia, cerebral autoregulatory responses are compromised.
Shiraz Badurdeen +7 more
doaj +2 more sources
Neurobiology of Disease, 1995 Nitric oxide (NO) has been implicated in the pathogenesis of brain injury from hypoxia-ischaemia. In the brain, the enzyme responsible for NO synthesis is neuronal nitric oxide synthase (nNOS).
Stephen M Black +2 more
exaly +3 more sources
Brain and Neuroscience Advances, 2022 In the newborn brain, moderate-severe hypoxia–ischaemia induces glutamate excitotoxicity and inflammation, possibly via dysregulation of candidate astrocytic glutamate transporter ( Glt1 ) and pro-inflammatory cytokines (e.g.
Silvia Pregnolato +5 more
doaj +1 more source
Journal of Neuroinflammation, 2022 Background Neonatal stroke is a devastating insult that can lead to life-long impairments. In response to hypoxic–ischaemic injury, there is loss of neurons and glia as well as a neuroinflammatory response mediated by resident immune cells, including ...
Clara Bourget +2 more
doaj +1 more source
Insights into Imaging, 2022 Aim To describe the spectrum of parasagittal injury on MRI studies performed on children following severe perinatal term hypoxia–ischaemia, using a novel MRI grading system, and propose a new central pattern correlated with neuropathologic features ...
Shalendra Kumar Misser +5 more
doaj +1 more source