Results 81 to 90 of about 112,633 (288)
Advanced Science, EarlyView.This study presents a machine‐learning framework entitled MERLIN that infers the microanatomical localization of macrophages from single‐cell transcriptomic data in structured organs such as the kidney and brain. Applying this method to existing datasets from models of acute kidney injury and diabetic nephropathy uncovered spatially resolved insights ...
Junping Yin +18 more
wiley +1 more source
A p38MAPK/MK2 signaling pathway leading to redox stress, cell death and ischemia/reperfusion injury [PDF]
, 2014 Background Many diseases and pathological conditions are characterized by transient or constitutive overproduction of reactive oxygen species (ROS).
Ashraf, Muhammad Imtiaz +17 more
core +2 more sources
Astrocyte Enrichment of 3D Cortical Constructs Enhances Brain Repair
Advanced Science, EarlyView.This study highlights the role of astrocytes in supporting neural progenitor cell survival and differentiation after traumatic brain injury. Astrocytes enhanced neuronal differentiation, improved cell survival in co‐cultures, and promoted integration of microfluidics‐based implants with host tissue following implantation. Additionally, increased axonal
Elisa M. Cruz +20 more
wiley +1 more source
Barrier mechanisms in neonatal stroke. [PDF]
, 2014 Clinical data continue to reveal that the incidence of perinatal stroke is high, similar to that in the elderly. Perinatal stroke leads to significant morbidity and severe long-term neurological and cognitive deficits, including cerebral palsy ...
Chip, Sophorn +2 more
core +2 more sources
Lactylation‐Driven YTHDC1 Alleviates MASLD by Suppressing PTPN22‐Mediated Dephosphorylation of NLRP3
Advanced Science, EarlyView.In MASLD, YTHDC1 undergoes increased lactylation and ubiquitination, reducing its expression. AARS1 mediates lactylation at lysine 565, while disrupted binding to LDHA further promotes lactylation, suppressing YTHDC1. This downregulation enhances PTPN22 mRNA stability, leading to NLRP3 dephosphorylation and activation, which exacerbates inflammation ...
Feng Zhang +16 more
wiley +1 more source
Frontiers in Cellular Neuroscience, 2016 Conditions of increased oxidative stress including cerebral ischemia can lead to blood-brain barrier (BBB) dysfunction via matrix metalloproteinase (MMP).
So Yeong Cheon +9 more
doaj +1 more source
Propofol Pretreatment Protects Hippocampal CA1 Neurons from Ischemia-reperfusion Injury in Rat
Otorhinolaryngology and Facial Plastic Surgery, 2023 Background: The number of brain strokes induced by ischemia has increased significantly in recent years as a result of brain vascular disorders. Some of these patients will require brain vascular surgery.
Delaram Farhangi +3 more
doaj +1 more source
Na(+)/H (+) Exchangers and Intracellular pH in Perinatal Brain Injury. [PDF]
, 2014 Encephalopathy consequent on perinatal hypoxia-ischemia occurs in 1-3 per 1,000 term births in the UK and frequently leads to serious and tragic consequences that devastate lives and families, with huge financial burdens for society.
Robertson, NJ, Uria-Avellanal, C
core +2 more sources
Advanced Science, EarlyView.6 nm iron oxide nanoparticles (IONP6) exhibit enzyme‐like activities that scavenge reactive oxygen and nitrogen species (RONS), including nitric oxide (NO). In stroke models, IONP6 promotes microglial polarization toward the M2 phenotype, reduces neuroinflammation, and improves neurological outcomes, offering a promising drug‐free approach to mitigate ...
Yilin Qi +12 more
wiley +1 more source
Role of HIF-1α-activated Epac1 on HSC-mediated neuroplasticity in stroke model
Neurobiology of Disease, 2013 Exchange protein activated by cAMP-1 (Epac1) plays an important role in cell proliferation, cell survival and neuronal signaling, and activation of Epac1 in endothelial progenitor cells increases their homing to ischemic muscles and promotes ...
Chen-Huan Lin +11 more
doaj +1 more source