Results 21 to 30 of about 1,114,410 (399)
Hypoxia and Hypoxia-Inducible Factors in Leukemias [PDF]
Frontiers in Oncology, 2016 Despite huge improvements in the treatment of leukemia, the percentage of patients suffering relapse still remains significant. Relapse most often results from a small number of leukemic stem cells (LSCs) within the bone marrow, which are able to self-renew, and therefore reestablish the full tumor.
Margaux eDeynoux +4 more
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Cancer Cell International, 2021 Hypoxia is a common feature of solid tumors, and develops because of the rapid growth of the tumor that outstrips the oxygen supply, and impaired blood flow due to the formation of abnormal blood vessels supplying the tumor.
Asieh Emami Nejad +12 more
semanticscholar +1 more source
Hypoxia and Inflammation [PDF]
New England Journal of Medicine, 2011 To the Editor: In their review article on hypoxia and inflammation, Eltzschig and Carmeliet (Feb. 17 issue)1 were thorough in promoting the role of hypoxia-inducible transcription factor (HIF) and related mechanisms to regain homeostasis in hypoxic tissue environments. Although very exacting in its discussion, the review unfortunately failed to include
Jo-Dee L. Lattimore +2 more
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Hypoxia. Hypoxia in the pathogenesis of systemic sclerosis [PDF]
Arthritis Research & Therapy, 2009 Autoimmunity, microangiopathy and tissue fibrosis are hallmarks of systemic sclerosis (SSc). Vascular alterations and reduced capillary density decrease blood flow and impair tissue oxygenation in SSc. Oxygen supply is further reduced by accumulation of extracellular matrix (ECM), which increases diffusion distances from blood vessels to cells ...
Beyer, C +4 more
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Hypoxia. Hypoxia, hypoxia inducible factor and myeloid cell function [PDF]
Arthritis Research & Therapy, 2009 With little in the way of effective therapeutic strategies to target the innate immune response, a better understanding of the critical pathways regulating neutrophil and macrophage responses in inflammation is key to the development of novel therapies.
Walmsley, SR, Chilvers, ER, Whyte, MKB
openaire +4 more sources
Life, 2023 Background: Athletes often experience poor sleep quality due to stress, altitude exposure, travel across different time zones, and pre-competition nervousness.
Felix Willmer +5 more
doaj +1 more source
Divergent mutational processes distinguish hypoxic and normoxic tumours. [PDF]
, 2020 Many primary tumours have low levels of molecular oxygen (hypoxia), and hypoxic tumours respond poorly to therapy. Pan-cancer molecular hallmarks of tumour hypoxia remain poorly understood, with limited comprehension of its associations with specific ...
Bhandari, Vinayak +4 more
core +1 more source
Hypoxia and Hypoxia-Inducible Factors in Lymphedema
Frontiers in Pharmacology, 2022 Lymphedema is a chronic inflammatory disorder characterized by edema, fat deposition, and fibrotic tissue remodeling. Despite significant advances in lymphatic biology research, our knowledge of lymphedema pathology is incomplete. Currently, there is no approved pharmacological therapy for this debilitating disease.
Xinguo Jiang +13 more
openaire +3 more sources
Hypoxia in Atherogenesis [PDF]
Angiology, 2016 The anoxemia theory proposes that an imbalance between the demand for and supply of oxygen in the arterial wall is a key factor in the development of atherosclerosis. There is now substantial evidence that there are regions within the atherosclerotic plaque in which profound hypoxia exists; this may fundamentally change the function, metabolism, and ...
Lamia Heikal, Gordon A. Ferns
openaire +3 more sources
Hypoxia and hypoxia-inducible factors in diabetes and its complications
Diabetologia, 2021 Hypoxia-inducible factors (HIFs) are the key regulators of oxygen homeostasis in response to hypoxia. In diabetes, multiple tissues are hypoxic but adaptive responses to hypoxia are impaired due to insufficient activation of HIF signalling, which results
S. Catrina, Xiaowei Zheng
semanticscholar +1 more source