Results 21 to 30 of about 939,686 (311)
Pulmonary Circulation, 2020 In some subjects, high-altitude hypobaric hypoxia leads to high-altitude pulmonary hypertension. The threshold for the diagnosis of high-altitude pulmonary hypertension is a mean pulmonary artery pressure of 30 mmHg, even though for general pulmonary ...
Julio Brito +2 more
doaj +1 more source
Oxydative stress in type 2 diabetic patients: involvement of HIF-1 alpha AND mTOR genes expression [PDF]
The Ukrainian Biochemical Journal, 2023 Biochemical and genetic mechanisms of oxidative stress (OS) developing in the blood of patients with type 2 Diabetes mellitus (T2DM) were studied. Twenty patients with T2DM and 10 healthy persons participated in this study.
Y. A. Saenko +5 more
doaj +1 more source
Intrapulmonary shunting and pulmonary gas exchange during normoxic and hypoxic exercise in healthy humans [PDF]
, 2008 Exercise-induced intrapulmonary arteriovenous shunting, as detected by saline contrast echocardiography, has been demonstrated in healthy humans. We have previously suggested that increases in both pulmonary pressures and blood flow associated with ...
Eldridge, MW +5 more
core +2 more sources
Stem Cell Research, 2021 A human induced pluripotent stem cell (hiPSC) line (WMUi020-A) was generated from the aortic smooth muscle cells of a 56-year-old donor with bicuspid aortic valve and ascending aortic aneurysm.
Li Dong +9 more
doaj +1 more source
Research progress of orexin on the regulation of cardiovascular activities [PDF]
Jichu yixue yu linchuang, 2023 Orexin(OX) is a neuropeptide mainly released by the hypothalamus. In the central nervous system, orexin neurons form extensive connections with other neuronal nuclei and participate in energy metabolism, sleep cycle and cardiovascular activity regulation.
ZHU Minxia
doaj +1 more source
Hypoxia up-regulates SERPINB3 through HIF-2\u3b1 in human liver cancer cells. [PDF]
, 2015 SERPINB3 is a cysteine-proteases inhibitor up-regulated in a significant number of cirrhotic patients carrying hepatocellular carcinoma (HCC) and recently proposed as a prognostic marker for HCC early recurrence.
Autelli, Riccardo +20 more
core +3 more sources
Hypoxic regulation of ion channel function and expression [PDF]
, 2002 Acute hypoxia regulates the activity of specific ion channels in a rapid and reversible manner. Such effects underlie appropriate cellular responses to hypoxia which are designed to initiate cardiorespiratory reflexes and contribute importantly to other ...
Peers, C.
core +1 more source
Pulmonary Circulation, 2020 In healthy vascular endothelium, nitric oxide acts as a vasodilator paracrine mediator on adjacent smooth muscle cells. By activating soluble guanylyl cyclase, nitric oxide stimulates cyclic guanosine monophosphate (cGMP) which causes relaxation of ...
Rainer Böger, Juliane Hannemann
doaj +1 more source
Frontiers in Medicine, 2022 Sleep Apnea Syndrome (SAS) is one of the most common chronic diseases, affecting nearly one billion people worldwide. The repetitive occurrence of abnormal respiratory events generates cyclical desaturation-reoxygenation sequences known as intermittent ...
Jonathan Gaucher +19 more
doaj +1 more source
One special question to start with: can HIF/NFkB be a target in inflammation? [PDF]
, 2015 Hypoxia and Inflammation are strictly interconnected with important consequences at clinical and therapeutic level. While cell and tissue damage due to acute hypoxia mostly leads to cell necrosis, in chronic hypoxia, cells that are located closer to ...
CARNEVALE, ILARIA +8 more
core +1 more source