Results 21 to 30 of about 1,131,072 (401)
Hypoxia. Hypoxia, hypoxia inducible factor and myeloid cell function [PDF]
Arthritis Research & Therapy, 2009 With little in the way of effective therapeutic strategies to target the innate immune response, a better understanding of the critical pathways regulating neutrophil and macrophage responses in inflammation is key to the development of novel therapies.
Walmsley, SR, Chilvers, ER, Whyte, MKB
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Journal of Molecular Medicine, 2007 A major feature of solid tumours is hypoxia, decreased availability of oxygen, which increases patient treatment resistance and favours tumour progression. How hypoxic conditions are generated in tumour tissues and how cells respond to hypoxia are essential questions in understanding tumour progression and metastasis.
Johanna Chiche +2 more
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Hypoxia in Atherogenesis [PDF]
Angiology, 2016 The anoxemia theory proposes that an imbalance between the demand for and supply of oxygen in the arterial wall is a key factor in the development of atherosclerosis. There is now substantial evidence that there are regions within the atherosclerotic plaque in which profound hypoxia exists; this may fundamentally change the function, metabolism, and ...
Lamia Heikal, Gordon A. Ferns
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Hypoxia and Hypoxia-Inducible Factors in Lymphedema
Frontiers in Pharmacology, 2022 Lymphedema is a chronic inflammatory disorder characterized by edema, fat deposition, and fibrotic tissue remodeling. Despite significant advances in lymphatic biology research, our knowledge of lymphedema pathology is incomplete. Currently, there is no approved pharmacological therapy for this debilitating disease.
Xinguo Jiang +13 more
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Hypoxia and hypoxia-inducible factors in diabetes and its complications
Diabetologia, 2021 Hypoxia-inducible factors (HIFs) are the key regulators of oxygen homeostasis in response to hypoxia. In diabetes, multiple tissues are hypoxic but adaptive responses to hypoxia are impaired due to insufficient activation of HIF signalling, which results
S. Catrina, Xiaowei Zheng
semanticscholar +1 more source
Hypoxia and hypoxia-inducible factors in neuroblastoma [PDF]
Cell and Tissue Research, 2017 Hypoxia (i.e., low oxygen levels) is a known feature of aggressive tumors. Cells, including tumor cells, respond to conditions of insufficient oxygen by activating a transcriptional program mainly driven by hypoxia-inducible factors (HIF)-1 and HIF-2.
Sofie Mohlin, Sven Påhlman
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Proceedings of the National Academy of Sciences of the United States of America, 1995 Hypoxia-inducible factor 1 (HIF-1) is found in mammalian cells cultured under reduced O2 tension and is necessary for transcriptional activation mediated by the erythropoietin gene enhancer in hypoxic cells.
Guang-lei Wang +3 more
semanticscholar +1 more source
International Journal of Molecular Sciences, 2021 Chronic (continuous, non-interrupted) hypoxia and cycling (intermittent, transient) hypoxia are two types of hypoxia occurring in malignant tumors. They are both associated with the activation of hypoxia-inducible factor-1 (HIF-1) and nuclear factor κB ...
J. Korbecki +6 more
semanticscholar +1 more source
The paradox between resistance to hypoxia and liability to hypoxic damage in hyperglycemic peripheral nerves. Evidence for glycolysis involvement [PDF]
, 1993 Isolated ventral and dorsal rat spinal roots incubated in normal (2.5 mM) or high glucose (25 mM) concentrations or in high concentrations of other hexoses were exposed transiently to hypoxia (30 min) in a solution of low buffering power.
Grafe, Peter +2 more
core +1 more source
Frontiers in Immunology, 2022 Chronic ethanol abuse is a systemic disorder and a risk factor for acute respiratory distress syndrome (ARDS) and chronic obstructive pulmonary disease (COPD). However, the mechanisms involved are unknown.
Wenhua Sang +6 more
doaj +1 more source