A mathematical study of the influence of hypoxia and acidity on the evolutionary dynamics of cancer [PDF]
arXiv, 2020 Hypoxia and acidity act as environmental stressors promoting selection for cancer cells with a more aggressive phenotype. As a result, a deeper theoretical understanding of the spatio-temporal processes that drive the adaptation of tumour cells to hypoxic and acidic microenvironments may open up new avenues of research in oncology and cancer treatment.
arxiv
Deciphering a Sleeping Pathogen: Uncovering Novel Transcriptional Regulators of Hypoxia-Induced Dormancy in Mycobacterium Tuberculosis [PDF]
arXiv, 2023 Along the pathogenesis of Mycobacterium Tuberculosis (MTB), hypoxia-induced dormancy is a process involving the oxygen-depleted environment encountered inside the lung granuloma, where bacilli enter a viable, non-replicating state termed as latency. Affecting nearly two billion people, latent TB can linger in the host for indefinite periods of time ...
arxiv
Modeling HIF-ILK Interaction Using Continuous Petri Nets [PDF]
Proceedings of the 18th International Joint Conference on
Biomedical Engineering Systems and Technologies - BIOINFORMATICS, 2025Oxygen concentration in tumor micro-environment is a well-established signal that can induce aggressive cancer behaviour. In particular, low oxygen levels (hypoxia) activate the Hypoxia-Inducible Factor(HIF) pathway which has an array of target systems.
arxiv +1 more source
What drives Oregon shelf summer hypoxia? [PDF]
arXiv, 2019 Using coupled biological-physical model based on NPZD-type biological model and 3D coastal ocean model (ROMS) we studied dissolved oxygen (DO) dynamics and hypoxia development on Oregon shelf during April-August of 2002, 2006, and 2008. We found that shelf hypoxia existed during summer months of all three years.
arxiv
Deterministic and stochastic aspects of VEGF-A production and the cooperative behavior of tumoral cell colony [PDF]
, 2010 A model is proposed to study the process of hypoxia-induced angiogenesis in cancer cells. The model accounts for the role played by the vascular endothelial growth factor (VEGF)-A in regulating the oxygen intake. VEGF-A is dynamically controlled by the HIF-1alpha concentration. If not degraded, HIF-1alpha can bind to the subunit termed HIF-1beta and so
arxiv +1 more source
Comparison of Epilepsy Induced by Ischemic Hypoxic Brain Injury and Hypoglycemic Brain Injury using Multilevel Fusion of Data Features [PDF]
Fusion: Practice and Applications Volume 10 , Issue 1 , PP:
100-115, 2023The study aims to investigate the similarities and differences in the brain damage caused by Hypoxia-Ischemia (HI), Hypoglycemia, and Epilepsy. Hypoglycemia poses a significant challenge in improving glycemic regulation for insulin-treated patients, while HI brain disease in neonates is associated with low oxygen levels.
arxiv +1 more source
Modeling the dynamics of hypoxia inducible factor-1α (HIF-1α) within single cells and 3D cell culture systems [PDF]
arXiv, 2014 HIF (Hypoxia Inducible Factor) is an oxygen-regulated transcription factor that mediates the intracellular response to hypoxia in human cells. There is increasing evidence that cell signaling pathways encode temporal information, and thus cell fate may be determined by the dynamics of protein levels.
arxiv
An analytic, moment-based method to estimate orthopositronium lifetimes in positron annihilation lifetime spectroscopy measurements [PDF]
Bio-Algorithms and Med-Systems 2024; 20 (Spec. Issue): 40-48The presence of tumor hypoxia is known to correlate with poor patient prognosis. Measurement of tissue oxygen concentration can be challenging, but recent advancements using positron annihilation lifetime spectroscopy (PALS) in three-dimensional positron emission tomography (PET) scans have shown promise for hypoxia detection.
arxiv +1 more source
Simultaneous Polysomnography and Cardiotocography Reveal Temporal Correlation Between Maternal Obstructive Sleep Apnea and Fetal Hypoxia [PDF]
arXivBackground: Obstructive sleep apnea syndrome (OSAS) during pregnancy is common and can negatively affect fetal outcomes. However, studies on the immediate effects of maternal hypoxia on fetal heart rate (FHR) changes are lacking. Methods: We used time-synchronized polysomnography (PSG) and cardiotocography (CTG) data from two cohorts to analyze the ...
arxiv
Hypoxia-inducible factor 1a protects peripheral sensory neurons from diabetic peripheral neuropathy by suppressing accumulation of reactive oxygen species [PDF]
arXiv, 2018 Diabetic peripheral neuropathy (DPN) is one of the most common diabetic complications. Mechanisms underlying nerve damage and sensory loss following metabolic dysfunction remain large unclear. Recently, hyperglycemia-induced mitochondrial dysfunction and the generation of ROS have gained attention as possible mechanisms of organ damage in diabetes ...
arxiv