Results 41 to 50 of about 927,905 (356)
Clinical Cancer Research, 2007 In this issue of Clinical Cancer Research , Rofstad et al. ([1][1]) report on the significance of chronic (diffusion-limited) and acute (fluctuating or perfusion-limited) hypoxia in D-12 and R-18 human melanoma xenografts on the development of metastatic disease.
Naz Chaudary, Richard P. Hill
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Pulmonary Circulation, 2020 In healthy vascular endothelium, nitric oxide acts as a vasodilator paracrine mediator on adjacent smooth muscle cells. By activating soluble guanylyl cyclase, nitric oxide stimulates cyclic guanosine monophosphate (cGMP) which causes relaxation of ...
Rainer Böger, Juliane Hannemann
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Frontiers in Medicine, 2022 Sleep Apnea Syndrome (SAS) is one of the most common chronic diseases, affecting nearly one billion people worldwide. The repetitive occurrence of abnormal respiratory events generates cyclical desaturation-reoxygenation sequences known as intermittent ...
Jonathan Gaucher +19 more
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Experimental & Molecular Medicine, 2019 Eukaryotic cells require sufficient oxygen (O2) for biological activity and survival. When the oxygen demand exceeds its supply, the oxygen levels in local tissues or the whole body decrease (termed hypoxia), leading to a metabolic crisis, threatening physiological functions and viability.
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Italian Journal of Pediatrics, 2015 More or less severe asthma attacks can damage the CNS and peripheral system in adults and children, both directly causing hypoxia and indirectly with the production of autoimmune antibodies. The pathogenic mechanism is still unknown; cytokines, TNFs, interleukins, free radicals and nitric oxide are often involved as causative factors for the ...
Pavone P, Falsaperla R
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Biomolecules, 2022 Neurogenesis plays an important role in the prognosis of stroke patients and is known to be promoted by the activation of the Notch1 signaling pathway. Studies on the airway epithelium have shown that miR-449b represses the Notch pathway. The study aimed
Sijie Li +11 more
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One special question to start with: can HIF/NFkB be a target in inflammation? [PDF]
, 2015 Hypoxia and Inflammation are strictly interconnected with important consequences at clinical and therapeutic level. While cell and tissue damage due to acute hypoxia mostly leads to cell necrosis, in chronic hypoxia, cells that are located closer to ...
CARNEVALE, ILARIA +8 more
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Hypoxia and hyperglycaemia determine why some endometrial tumours fail to respond to metformin [PDF]
, 2020 High expression of Ki67, a proliferation marker, is associated with reduced endometrial cancer-specific survival. Pre-surgical metformin reduces tumour Ki-67 expression in some women with endometrial cancer. Metformin's anti-cancer activity may relate to
Crosbie, EJ +9 more
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Normobaric hypoxia overnight impairs cognitive reaction time
BMC Neuroscience, 2017 Background Impaired reaction time in patients suffering from hypoxia during sleep, caused by sleep breathing disorders, is a well-described phenomenon. High altitude sleep is known to induce periodic breathing with central apneas and oxygen desaturations,
Stephan Pramsohler +6 more
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Controls of Nuclear Factor-Kappa B Signaling Activity by 5’-AMP-Activated Protein Kinase Activation With Examples in Human Bladder Cancer Cells [PDF]
International Neurourology Journal, 2016 Generally, both lipopolysaccharide (LPS)- and hypoxia-induced nuclear factor kappa B (NF-κB) effects are alleviated through differential posttranslational modification of NF-κB phosphorylation after pretreatment with 5´-AMP-activated protein kinase (AMPK)
Bo-Hwa Choi +4 more
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