Results 41 to 50 of about 552,789 (215)
Open Life Sciences, 2023 Curcumin is the most abundant derivative of turmeric rhizome. Although studies have proved that curcumin could inhibit the growth of tumors, its specific molecular mechanism has not yet been fully elucidated.
Wang Xiaoping +4 more
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Neoplasia: An International Journal for Oncology Research, 2022 Regions of low oxygen (hypoxia) are found in >50% of breast tumours, most frequently in the more aggressive triple negative breast cancer subtype (TNBC). Metastasis is the cause of 90% of breast cancer patient deaths. Regions of tumour hypoxia tend to be
Christopher Paul Carroll +8 more
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Editorial for Life Special Issue Book Cellular and Functional Response to Hypoxia
Life, 2022 Hypoxia is a current research topic in biology, physiology, and medicine [...]
Jean-Paul Richalet
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The role of orexin A in the pathogenesis of ischaemic stroke at high altitude
Experimental PhysiologyOrexin offers protection against cerebral ischaemia–reperfusion injury, with high altitude playing a key role in modulating its expression. This study aimed to investigate the effect of high altitude on orexin expression and its pathophysiological ...
Minxia Zhu +7 more
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RNF144A-AS1, a TGF-β1- and hypoxia-inducible gene that promotes tumor metastasis and proliferation via targeting the miR-30c-2-3p/LOX axis in gastric cancer [PDF]
, 2021 Zengliang Li +5 more
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LncRNA GAS5 restrains ISO-induced cardiac fibrosis by modulating mir-217 regulation of SIRT1
Scientific ReportsConsidering the effect of SIRT1 on improving myocardial fibrosis and GAS5 inhibiting occurrence and development of myocardial fibrosis at the cellular level, the aim of the present study was to investigate whether LncRNA GAS5 could attenuate cardiac ...
Yan-hong Zhang +5 more
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Brain Research BulletinThe purpose of this study was to investigate the protective effect and underlying mechanism of orexin A on cerebral ischemia-reperfusion injury, specifically through vasodilation mediated by the hypoxia inducible factor-1α (HIF-1α)-Endothelin-1(ET-1 ...
Minxia Zhu +9 more
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Metabolic and hypoxic adaptation to anti‐angiogenic therapy: a target for induced essentiality
EMBO Molecular Medicine, 2015 Anti‐angiogenic therapy has increased the progression‐free survival of many cancer patients but has had little effect on overall survival, even in colon cancer (average 6–8 weeks) due to resistance.
Alan McIntyre, Adrian L Harris
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Hypoxia. 3. Hypoxia and neurotransmitter synthesis
American Journal of Physiology-Cell Physiology, 2011 Central and peripheral neurons as well as neuroendocrine cells express a variety of neurotransmitters/modulators that play critical roles in regulation of physiological systems. The synthesis of several neurotransmitters/modulators is regulated by O2-requiring rate-limiting enzymes.
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Scientific Reports, 2017 Migration of olfactory ensheathing cells (OECs) is critical for development of olfactory system and essential for neural regeneration after OEC transplantation into nerve injury site.
Cheng-gen Zheng +9 more
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