Results 41 to 50 of about 1,114,410 (399)

Hypoxia, Hypoxia-Inducible Factors and Liver Fibrosis [PDF]

Cells, 2021
Liver fibrosis is a potentially reversible pathophysiological event, leading to excess deposition of extracellular matrix (ECM) components and taking place as the net result of liver fibrogenesis, a dynamic and highly integrated process occurring during chronic liver injury of any etiology.
Foglia Beatrice, Novo Erica, Protopapa Francesca, Maggiora Marina, Bocca Claudia, Cannito Stefania, Parola Maurizio   +6 more
openaire   +4 more sources

Long-term chronic intermittent hypoxia: a particular form of chronic high-altitude pulmonary hypertension

Pulmonary Circulation, 2020
In some subjects, high-altitude hypobaric hypoxia leads to high-altitude pulmonary hypertension. The threshold for the diagnosis of high-altitude pulmonary hypertension is a mean pulmonary artery pressure of 30 mmHg, even though for general pulmonary ...
Julio Brito, Patricia Siques, Eduardo Pena   +2 more
doaj   +1 more source

Upregulated integrin α11 in the stroma of cutaneous squamous cell carcinoma promotes skin carcinogenesis

Frontiers in Oncology, 2022
Integrin α11β1 is a collagen-binding integrin that is needed to induce and maintain the myofibroblast phenotype in fibrotic tissues and during wound healing.
Guillermo A. Martínez-Nieto, Hanna-Riikka Teppo, Hanna-Riikka Teppo, Hanna-Riikka Teppo, Noora Petrelius, Valerio Izzi, Valerio Izzi, Valerio Izzi, Raman Devarajan, Tiina Petäistö, Hengshuo Liu, Kris S. Kim, Sanna-Maria Karppinen, Heli Ruotsalainen, Jarkko Koivunen, Joni M. Mäki, Gilbert C. Walker, Taina Pihlajaniemi, Donald Gullberg, Ritva Heljasvaara, Ritva Heljasvaara   +20 more
doaj   +1 more source

Oxydative stress in type 2 diabetic patients: involvement of HIF-1 alpha AND mTOR genes expression [PDF]

The Ukrainian Biochemical Journal, 2023
Biochemical and genetic mechanisms of oxidative stress (OS) developing in the blood of patients with type 2 Diabetes mellitus (T2DM) were studied. Twenty patients with T2DM and 10 healthy persons participated in this study.
Y. A. Saenko, O. O. Gonchar, I. M. Mankovska, T. I. Drevytska, L. V. Bratus, B. M. Mankovsky   +5 more
doaj   +1 more source

Chronic and Cycling Hypoxia: Drivers of Cancer Chronic Inflammation through HIF-1 and NF-κB Activation: A Review of the Molecular Mechanisms

International Journal of Molecular Sciences, 2021
Chronic (continuous, non-interrupted) hypoxia and cycling (intermittent, transient) hypoxia are two types of hypoxia occurring in malignant tumors. They are both associated with the activation of hypoxia-inducible factor-1 (HIF-1) and nuclear factor κB ...
J. Korbecki, Donata Simińska, M. Gąssowska-Dobrowolska, J. Listos, I. Gutowska, D. Chlubek, I. Baranowska-Bosiacka   +6 more
semanticscholar   +1 more source

Regulation of glycolysis by the hypoxia‐inducible factor (HIF): implications for cellular physiology

Journal of Physiology, 2020
Under conditions of hypoxia, most eukaryotic cells can shift their primary metabolic strategy from predominantly mitochondrial respiration towards increased glycolysis to maintain ATP levels.
S. Kierans, C. Taylor
semanticscholar   +1 more source

The Effect of Hypoxia on the Expression of CXC Chemokines and CXC Chemokine Receptors—A Review of Literature

International Journal of Molecular Sciences, 2021
Hypoxia is an integral component of the tumor microenvironment. Either as chronic or cycling hypoxia, it exerts a similar effect on cancer processes by activating hypoxia-inducible factor-1 (HIF-1) and nuclear factor (NF-κB), with cycling hypoxia showing
J. Korbecki, K. Kojder, Patrycja Kapczuk, P. Kupnicka, B. Gawrońska-Szklarz, I. Gutowska, D. Chlubek, I. Baranowska-Bosiacka   +7 more
semanticscholar   +1 more source

Role of hypoxia in cancer therapy by regulating the tumor microenvironment

Molecular Cancer, 2019
Clinical resistance is a complex phenomenon in major human cancers involving multifactorial mechanisms, and hypoxia is one of the key components that affect the cellular expression program and lead to therapy resistance.
Xinming Jing, Fengming Yang, C. Shao, Ke Wei, M. Xie, H. Shen, Y. Shu   +6 more
semanticscholar   +1 more source

Vascular changes in the rat brain during chronic hypoxia in the presence and absence of hypercapnia. [PDF]

, 2005
Changes in brain vascularity in adult rats during adaptation to chronic normobaric hypoxia with or without elevated CO(2) were morphometrically investigated.
Hayashida, Yoshiaki, Hirakawa, Haruhisa, Itano, Toshifumi, Kusakabe, Tatsumi, Miyamoto, Osamu, Sumitani, kazunori, Takahashi, Masaru   +6 more
core   +1 more source

The Influence of Body Size and Hemoglobin Multiplicity on Critical Oxygen Threshold in Red Drum (Sciaenops ocellatus) [PDF]

, 2016
Hypoxia is common in marine environments and fishes use a suite of cardiorespiratory adjustments to defend aerobic metabolism, including reducing standard metabolic rate (SMR), the minimum metabolic rate needed to sustain life at a specified temperature,
Pan, Yihang
core   +1 more source