Results 41 to 50 of about 956,013 (356)
Frontiers in Medicine, 2022 Sleep Apnea Syndrome (SAS) is one of the most common chronic diseases, affecting nearly one billion people worldwide. The repetitive occurrence of abnormal respiratory events generates cyclical desaturation-reoxygenation sequences known as intermittent ...
Jonathan Gaucher +19 more
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More oxygen during development enhanced flight performance but not thermal tolerance of Drosophila melanogaster [PDF]
, 2017 High temperatures can stress animals by raising the oxygen demand above the oxygen supply. Consequently, animals under hypoxia could be more sensitive to heating than those exposed to normoxia.
Angilletta Jr., Michael J. +4 more
core +2 more sources
Hypoxia. 2. Hypoxia regulates cellular metabolism
American Journal of Physiology-Cell Physiology, 2011 Adaptation to lowering oxygen levels (hypoxia) requires coordinated downregulation of metabolic demand and supply to prevent a mismatch in ATP utilization and production that might culminate in a bioenergetic collapse. Hypoxia diminishes ATP utilization by downregulating protein translation and the activity of the Na-K-ATPase.
William W, Wheaton, Navdeep S, Chandel
openaire +3 more sources
Normobaric hypoxia overnight impairs cognitive reaction time
BMC Neuroscience, 2017 Background Impaired reaction time in patients suffering from hypoxia during sleep, caused by sleep breathing disorders, is a well-described phenomenon. High altitude sleep is known to induce periodic breathing with central apneas and oxygen desaturations,
Stephan Pramsohler +6 more
doaj +1 more source
Pulmonary Circulation, 2020 In healthy vascular endothelium, nitric oxide acts as a vasodilator paracrine mediator on adjacent smooth muscle cells. By activating soluble guanylyl cyclase, nitric oxide stimulates cyclic guanosine monophosphate (cGMP) which causes relaxation of ...
Rainer Böger, Juliane Hannemann
doaj +1 more source
SUMOylation of NaV1.2 channels mediates the early response to acute hypoxia in central neurons. [PDF]
, 2016 The mechanism for the earliest response of central neurons to hypoxia-an increase in voltage-gated sodium current (INa)-has been unknown. Here, we show that hypoxia activates the Small Ubiquitin-like Modifier (SUMO) pathway in rat cerebellar granule ...
Goldstein, Steve An +2 more
core +2 more sources
Biomolecules, 2022 Neurogenesis plays an important role in the prognosis of stroke patients and is known to be promoted by the activation of the Notch1 signaling pathway. Studies on the airway epithelium have shown that miR-449b represses the Notch pathway. The study aimed
Sijie Li +11 more
doaj +1 more source
Experimental Models of Sarcopenia: Bridging Molecular Mechanism and Therapeutic Strategy
Cells, 2020 Sarcopenia has been defined as a progressive decline of skeletal muscle mass, strength, and functions in elderly people. It is accompanied by physical frailty, functional disability, falls, hospitalization, and mortality, and is becoming a major ...
Sakulrat Mankhong +5 more
doaj +1 more source
Controls of Nuclear Factor-Kappa B Signaling Activity by 5’-AMP-Activated Protein Kinase Activation With Examples in Human Bladder Cancer Cells [PDF]
International Neurourology Journal, 2016 Generally, both lipopolysaccharide (LPS)- and hypoxia-induced nuclear factor kappa B (NF-κB) effects are alleviated through differential posttranslational modification of NF-κB phosphorylation after pretreatment with 5´-AMP-activated protein kinase (AMPK)
Bo-Hwa Choi +4 more
doaj +1 more source
Effect of acute severe hypoxia on peripheral fatigue and endurance capacity in healthy humans [PDF]
, 2007 Effect of acute severe hypoxia on peripheral fatigue and endurance capacity in healthy humans. Am J Physiol Regul Integr Comp Physiol 292: R598–R606, 2007. First published September 7, 2006; doi:10.1152/ajpregu.00269.2006.—We hypothesized that severe
Amann, M +5 more
core +2 more sources