Results 61 to 70 of about 1,131,072 (401)

Generation of human induced pluripotent stem cell line (WMUi001-A) from a patient with aortic dissection

Stem Cell Research, 2020
A human induced pluripotent stem cell (hiPSC) line (WMUi001-A) was generated from the aortic tissue of a 47-year-old donor with aortic dissection and normal blood pressure.
Peifeng Jin, Sixian Wang, Xu Jiang, Xiaoqiong Shan, Sheng Jiang, Yingyi Quan, Tianci Zhang, Jiwen Yang, Huang Zhang, Jianshe Ma, Miaowu Dong, Junming Fan, Xiaofang Fan, Yongsheng Gong, Yongyu Wang   +14 more
doaj  

Hypoxia up-regulates SERPINB3 through HIF-2\u3b1 in human liver cancer cells. [PDF]

, 2015
SERPINB3 is a cysteine-proteases inhibitor up-regulated in a significant number of cirrhotic patients carrying hepatocellular carcinoma (HCC) and recently proposed as a prognostic marker for HCC early recurrence.
Autelli, Riccardo, Biasiolo, A, Cambieri, I, Cannito, Stefania, Cillo, U, Cillo, U, Colombatto, Sebastiano, David, E, Fasolato, S, Morello, E, Musso, Tiziana, Novo, Erica, Parola, Maurizio, Paternostro, Claudia, Pontisso, P, Quarta, S, Rovida, E, Smedile, Antonina, Turato, C, Tusa, I, Villano, G   +20 more
core   +3 more sources

The role of hypoxia in cancer progression, angiogenesis, metastasis, and resistance to therapy

Hypoxia, 2015
Hypoxia is a non-physiological level of oxygen tension, a phenomenon common in a majority of malignant tumors. Tumor-hypoxia leads to advanced but dysfunctional vascularization and acquisition of epithelial-to-mesenchymal transition phenotype resulting ...
B. Muz, P. de la Puente, F. Azab, A. Azab   +3 more
semanticscholar   +1 more source

Hypoxia and Inflammation: Insights From High-Altitude Physiology

Frontiers in Physiology, 2021
The key regulators of the transcriptional response to hypoxia and inflammation (hypoxia inducible factor, HIF, and nuclear factor-kappa B, NF-κB, respectively) are evolutionarily conserved and share significant crosstalk. Tissues often experience hypoxia
K. Pham, K. Parikh, Erica C Heinrich
semanticscholar   +1 more source

Hypoxia and calcium

Journal of Molecular and Cellular Cardiology, 1979
Abstract During hypoxia peak developed tension falls rapidly, resting tension inceeases slowly and recovery is incomplete if the hypoxia is sufficiently prolonged for resting tension to become greatly elevated. We propose that the initial fall of peak developed tension is due to a failure of excitation-contraction coupling at a time when high energy ...
Winifred G. Nayler, Alan J. Williams, P.A. Poole-Wilson   +2 more
openaire   +5 more sources

Beyond Pharmacology: The Biological Mechanisms of Remote Ischemic Conditioning in Cerebrovascular Disease

Biomolecules
Cerebrovascular diseases (CVDs), comprising predominantly ischemic stroke and chronic cerebral hypoperfusion (CCH), are a significant threat to global health, often leading to disability and mortality.
Linhui Qin, Fang Tong, Sijie Li, Changhong Ren   +3 more
doaj   +1 more source

Collagens Regulating Adipose Tissue Formation and Functions

Biomedicines, 2023
The globally increasing prevalence of obesity is associated with the development of metabolic diseases such as type 2 diabetes, dyslipidemia, and fatty liver.
Iida Jääskeläinen, Tiina Petäistö, Elahe Mirzarazi Dahagi, Mahdokht Mahmoodi, Taina Pihlajaniemi, Mari T. Kaartinen, Ritva Heljasvaara   +6 more
doaj   +1 more source

Hypoxia Signaling Pathway in Stem Cell Regulation: Good and Evil [PDF]

, 2018
Purpose of Review: This review summarizes the role of hypoxia and hypoxia-inducible factors (HIFs) in the regulation of stem cell biology, specifically focusing on maintenance, differentiation, and stress responses in the context of several stem cell ...
Aljoufi, Arafat, Broxmeyer, Hal E., Huang, Xinxin, Trinh, Thao   +3 more
core   +1 more source

Curcumin induces apoptosis in human hepatocellular carcinoma cells by decreasing the expression of STAT3/VEGF/HIF-1α signaling

Open Life Sciences, 2023
Curcumin is the most abundant derivative of turmeric rhizome. Although studies have proved that curcumin could inhibit the growth of tumors, its specific molecular mechanism has not yet been fully elucidated.
Wang Xiaoping, Tian Yu, Lin Huanping, Cao Xiaolan, Zhang Zhendong   +4 more
doaj   +1 more source

Hypoxia. 3. Hypoxia and neurotransmitter synthesis [PDF]

American Journal of Physiology-Cell Physiology, 2011
Central and peripheral neurons as well as neuroendocrine cells express a variety of neurotransmitters/modulators that play critical roles in regulation of physiological systems. The synthesis of several neurotransmitters/modulators is regulated by O2-requiring rate-limiting enzymes.
openaire   +3 more sources