Results 21 to 30 of about 672 (97)

Regular Medications Administered to Older Adults in Aged Care Facilities: A Retrospective Descriptive Study

Journal of Clinical Nursing, Volume 35, Issue 1, Page 363-374, January 2026.
ABSTRACT Aim(s) To explore which regularly prescribed medications are most commonly administered to older adults in aged care facilities in Australia, by whom and when, and to identify the prevalence of polypharmacy in this population group. Design Retrospective descriptive study.
Stephanie M. Garratt, Maneesh Prasad, Kelly Ottosen, Elizabeth Manias   +3 more
wiley   +1 more source

Selective knockout of murine glutamic acid‐rich protein 2 significantly alters dark continuous noise in rod photoreceptors

The Journal of Physiology, Volume 604, Issue 1, Page 460-478, 1 January 2026.
Abstract figure legend GARP2 has a minor role in maintaining the structural integrity of the rod outer segments as a function of age, but an important role in regulating rod photoreceptor continuous noise, likely through stabilization of PDE6 basal activity.
Delores A. Stacks, Ulisse Bocchero, Marci L. DeRamus, Mai N. Nguyen, Jeffrey Messinger, Timothy W. Kraft, Steven J. Pittler, Johan Pahlberg   +7 more
wiley   +1 more source

Effect of Preserved Versus Preservative‐Free Artificial Tears on the Corneal Epithelial Thickness Mapping by MS‐39 in Dry Eye Patients

Journal of Ophthalmology, Volume 2026, Issue 1, 2026.
Purpose To compare clinical and corneal epithelial changes between preservative and preservative‐free artificial tear therapy using the MS‐39 in patients with dry eye disease (DED). Methods This prospective interventional comparative study included 88 eyes of 44 patients. Preserved artificial tears were given for the left eye (group A) and preservative‐
Ghada A. Nassar, Ahmed Rashad Ashor, Mohamed Hosny, Jorge Alio, Aliaa A. Farag, Karuna Sharma   +5 more
wiley   +1 more source

Serial Chemical Crystallography for Autonomous Quantitative Phase Analysis in an Electron Microscope

Small Methods, Volume 9, Issue 12, December 1, 2025.
t‐SerialED, a novel electron diffraction method, enables rapid, high‐throughput structural analysis of nano‐sized materials. By adapting a batch‐by‐batch data collection approach, t‐SerialED integrates 3D reciprocal information to serial crystallography datasets.
Taimin Yang, David Geoffrey Waterman, Zheting Chu, James Beilsten‐Edmands, Zhehao Huang, Xiaodong Zou   +5 more
wiley   +1 more source

miR‐27a‐3p Upregulation and Netrin‐1 Deficiency Drive Inflammatory Responses and Nerve Degeneration in Patients With Diabetes

European Journal of Neurology, Volume 32, Issue 12, December 2025.
ABSTRACT Background Inflammation is increasingly recognized in the pathogenesis of diabetic neuropathy (DN). Circulating miR‐27a‐3p levels are closely related to inflammation and increased in patients with diabetic nephropathy and retinopathy. miR‐27a‐3p has a predicted binding site in the 3 UTR of Netrin‐1 mRNA, an anti‐inflammatory nerve growth ...
Asif Mondal, Sucharita Banerjee, Somnath Naskar, Chiranjit Bose, Chinmay Saha, Subhasish Pramanik, Bidisha Mukherjee, Piyali Jati, Pranab Kumar Sahana, Rayaz A. Malik, Satinath Mukhopadhyay   +10 more
wiley   +1 more source

Sestrin2 Exerts a Novel Protective Effect Against LPS‐Induced Ferroptosis via the Nrf2–SLC7A11–GPX4 Signaling Axis

The FASEB Journal, Volume 39, Issue 22, 30 November 2025.
This graphical abstract shows that LPS downregulates SESN2, leading to suppressed GPX4 activity, increased ROS, lipid peroxidation, and inflammation. SESN2 overexpression reverses these effects by activating the Nrf2/SLC7A11/GPX4 axis, reducing MDA and 4HNE levels, preserving redox balance, and alleviating ocular symptoms including hypopyon and retinal
Xuerui Zhang, Jiawei Yin, Yuan Yang, Jie Peng, Yu Xu, Wenting Zhang, Haodong Xiao, Zupeng Lu, Huanyu Liu, Yanjun Wen, Miaomiao Liu, Enguang Chen, Xiang Zhang, Shipeng Guo, Lianhui Han, Huazhang Feng, Peiquan Zhao   +16 more
wiley   +1 more source

A Novel Semi‐Automated Pipeline for Optimizing 3D‐Printed Drug Formulations

Advanced Intelligent Systems, Volume 7, Issue 11, November 2025.
A novel, semi‐automated deep learning and differential evolution pipeline designed for generating medicines for 3D‐printed medicines is introduced. This pipeline successfully generates a diverse range of drug formulations with an 80% printing success rate and 92% accuracy in predicting printing parameters.
Youssef Abdalla, Martin Ferianc, Haya Alfassam, Atheer Awad, Ruochen Qiao, Miguel Rodrigues, Mine Orlu, Abdul W. Basit, David Shorthouse   +8 more
wiley   +1 more source

Sustainable Shell Formulations as Alternative to the Conventional Soft Gelatin Capsules in Pharmaceutical and Nutraceutical Applications. A Review.

Macromolecular Materials and Engineering, Volume 310, Issue 8, August 2025.
In soft capsules (SCs), four crucial factors can modify the properties of the shell: the shell formulation, its interaction with the fill material, the SC production and its storage conditions. Gelatin is the most used gelling agent for SCs nowadays, but they have some drawbacks which can be solved including other alternative polymers in the shell ...
Francisco Javier Palomero‐Hernández, María Ángela Caballo‐González, Francisco Javier de la Mata, Sandra García‐Gallego   +3 more
wiley   +1 more source

Influence of artificial tears on corneal parameter measurement using three different devices: Keratometry and Scheimpflug technology, a randomized trial

Acta Ophthalmologica, Volume 103, Issue 5, Page e310-e317, August 2025.
Abstract Purpose To evaluate the effect of artificial tear (AT) application on the repeatability of corneal parameters with three different devices. Methods In this prospective, randomized clinical trial, 145 patients were measured with one of three devices in the Department of Ophthalmology, Goethe University, Frankfurt, Germany.
Titus Schug, Thomas Kohnen, Klemens Paul Kaiser, Christoph Lwowski   +3 more
wiley   +1 more source

Tracking the Progress of Biocomposites Based on Poly(3-hydroxybutyrate) with Hypromellose Additives via Thermal Analysis, Mechanical Properties, and Biological Studies. [PDF]

Int J Mol Sci
Maternia-Dudzik K, Ożóg Ł, Bober Z, Oliwa R, Oleksy M, Kamizela A, Szyszkowska A, Rafińska K, Gonciarz W, Gancarczyk K, Czerniecka-Kubicka A.   +10 more
europepmc   +1 more source