Results 31 to 40 of about 617,583 (137)

Selective knockout of murine glutamic acid‐rich protein 2 significantly alters dark continuous noise in rod photoreceptors

open access: yesThe Journal of Physiology, Volume 604, Issue 1, Page 460-478, 1 January 2026.
Abstract figure legend GARP2 has a minor role in maintaining the structural integrity of the rod outer segments as a function of age, but an important role in regulating rod photoreceptor continuous noise, likely through stabilization of PDE6 basal activity.
Delores A. Stacks   +7 more
wiley   +1 more source

Effect of Preserved Versus Preservative‐Free Artificial Tears on the Corneal Epithelial Thickness Mapping by MS‐39 in Dry Eye Patients

open access: yesJournal of Ophthalmology, Volume 2026, Issue 1, 2026.
Purpose To compare clinical and corneal epithelial changes between preservative and preservative‐free artificial tear therapy using the MS‐39 in patients with dry eye disease (DED). Methods This prospective interventional comparative study included 88 eyes of 44 patients. Preserved artificial tears were given for the left eye (group A) and preservative‐
Ghada A. Nassar   +5 more
wiley   +1 more source

Serial Chemical Crystallography for Autonomous Quantitative Phase Analysis in an Electron Microscope

open access: yesSmall Methods, Volume 9, Issue 12, December 1, 2025.
t‐SerialED, a novel electron diffraction method, enables rapid, high‐throughput structural analysis of nano‐sized materials. By adapting a batch‐by‐batch data collection approach, t‐SerialED integrates 3D reciprocal information to serial crystallography datasets.
Taimin Yang   +5 more
wiley   +1 more source

miR‐27a‐3p Upregulation and Netrin‐1 Deficiency Drive Inflammatory Responses and Nerve Degeneration in Patients With Diabetes

open access: yesEuropean Journal of Neurology, Volume 32, Issue 12, December 2025.
ABSTRACT Background Inflammation is increasingly recognized in the pathogenesis of diabetic neuropathy (DN). Circulating miR‐27a‐3p levels are closely related to inflammation and increased in patients with diabetic nephropathy and retinopathy. miR‐27a‐3p has a predicted binding site in the 3 UTR of Netrin‐1 mRNA, an anti‐inflammatory nerve growth ...
Asif Mondal   +10 more
wiley   +1 more source

Sestrin2 Exerts a Novel Protective Effect Against LPS‐Induced Ferroptosis via the Nrf2–SLC7A11–GPX4 Signaling Axis

open access: yesThe FASEB Journal, Volume 39, Issue 22, 30 November 2025.
This graphical abstract shows that LPS downregulates SESN2, leading to suppressed GPX4 activity, increased ROS, lipid peroxidation, and inflammation. SESN2 overexpression reverses these effects by activating the Nrf2/SLC7A11/GPX4 axis, reducing MDA and 4HNE levels, preserving redox balance, and alleviating ocular symptoms including hypopyon and retinal
Xuerui Zhang   +16 more
wiley   +1 more source

A Novel Semi‐Automated Pipeline for Optimizing 3D‐Printed Drug Formulations

open access: yesAdvanced Intelligent Systems, Volume 7, Issue 11, November 2025.
A novel, semi‐automated deep learning and differential evolution pipeline designed for generating medicines for 3D‐printed medicines is introduced. This pipeline successfully generates a diverse range of drug formulations with an 80% printing success rate and 92% accuracy in predicting printing parameters.
Youssef Abdalla   +8 more
wiley   +1 more source

Should We Fear Derivatives? [PDF]

open access: yes
This paper discusses the extent to which derivatives pose threats to firms and to the economy. After reviewing the derivatives markets and putting in perspective the various measures of the size of these markets, the paper shows who uses derivatives and ...
Rene M. Stulz
core  

Formulation of Extended-Release Gliclazide Tablet Using a Mathematical Model for Estimation of Hypromellose

open access: yes, 2017
Formulation of gliclazide in the form of extended-release tablet in 30 and 60 mg dosage forms was performed using hypromellose (HPMC K4M) as a retarding agent.
Faranak Jafari   +3 more
core   +1 more source

Sustainable Shell Formulations as Alternative to the Conventional Soft Gelatin Capsules in Pharmaceutical and Nutraceutical Applications. A Review.

open access: yesMacromolecular Materials and Engineering, Volume 310, Issue 8, August 2025.
In soft capsules (SCs), four crucial factors can modify the properties of the shell: the shell formulation, its interaction with the fill material, the SC production and its storage conditions. Gelatin is the most used gelling agent for SCs nowadays, but they have some drawbacks which can be solved including other alternative polymers in the shell ...
Francisco Javier Palomero‐Hernández   +3 more
wiley   +1 more source

Credit derivatives: an overview [PDF]

open access: yes
Arising from financial institutions' need to hedge and diversify credit risk, credit derivatives have now become a major investment tool. Almost all credit derivatives take the form of the credit default swap, which transfers default risk from one party ...
David Mengle
core  

Home - About - Disclaimer - Privacy