Results 221 to 230 of about 5,536 (239)

Generation of a novel attenuated IBDV vaccine strain by mutation of critical amino acids in IBDV VP5

Vaccine
Infectious bursal disease virus (IBDV) is an acute and highly infectious RNA virus known for its immunosuppressive capabilities, chiefly inflicting rapid damage to the bursa of Fabricius (BF) of chickens. Current clinical control of IBDV infection relies on vaccination.
Hui Gao, Shujun Zhang, He Chang, Yuxin Guo, Zhonghua Li, Yongqiang Wang, Li Gao, Xiaoqi Li, Hong Cao, Shijun J. Zheng   +9 more
openaire   +2 more sources

Determination of Optimum Formulation of a Novel Infectious Bursal Disease Virus (IBDV) Vaccine Constructed by Mixing Bursal Disease Antibody with IBDV

Avian Diseases, 1995
A novel vaccine against infectious bursal disease virus (IBDV) has been developed. The new vaccine was constructed by mixing bursal disease antibody (BDA) contained in whole antiserum with live IBDV before lyophilization. To establish various formulations of BDA and IBDV, several BDA doses between 5 units and 80 units of BDA/50 microliters were mixed ...
C E, Whitfill, E E, Haddad, C A, Ricks, J K, Skeeles, L A, Newberry, J N, Beasley, P D, Andrews, J A, Thoma, P S, Wakenell   +8 more
openaire   +2 more sources

Optineurin inhibits IBDV replication via interacting with VP1

Veterinary Microbiology
Avibirnavirus, specifically Infectious Bursal Disease Virus (IBDV), is a highly contagious pathogen that causes significant economic losses in the poultry industry. The polymerase protein VP1 of IBDV is critical to the viral life cycle, facilitating the synthesis of viral mRNA and the genome.
Zhixuan, Xiong, Qinghua, Zeng, Ying, Hu, Chongde, Lai, Huansheng, Wu   +4 more
openaire   +2 more sources

Virus-like particles of hepatitis B virus core protein containing five mimotopes of infectious bursal disease virus (IBDV) protect chickens against IBDV

Vaccine, 2012
Current infectious bursal disease virus (IBDV) vaccines suffer from maternal antibody interference and mimotope vaccines might be an alternative. Previously we demonstrated an IBDV VP2 five-mimotope polypeptide, 5EPIS, elicited protective immunity in chickens.
Yong-shan, Wang, Wei, Ouyang, Xiao-juan, Liu, Kong-wang, He, Sheng-qing, Yu, Hai-bin, Zhang, Hong-jie, Fan, Cheng-ping, Lu   +7 more
openaire   +2 more sources

Picroside II disrupts IBDV replication via targeting VP1 polymerase

Veterinary Microbiology
Infectious bursal disease virus (IBDV) is a highly contagious virus with a dsRNA genome, predominantly infecting chickens and causing significant economic losses due to high mortality rates. The emergence of recombinant, novel variant, and highly virulent strains that evade current vaccines has led to frequent epidemics and outbreaks in the poultry ...
Donghu, Zhang, Jing, Wang, Huansheng, Wu, Qili, Chen   +3 more
openaire   +2 more sources

Studies on Interferon Induction by Infectious Bursal Disease Virus (IBDV). I. Interferon Production in Chicken Embryo Cell Cultures Infected with IBDV

Avian Diseases, 1979
SUMMARY Two isolants of infectious bursal disease virus (IBDV) were found to induce interferon production in chicken embryo fibroblast (CEF) cell cultures. Both isolants were similar in one-step multiplication cycles and interferon-inducing properties. Interferon production was closely related to virus multiplication.
J. Gelb, C. S. Eidson, S. H. Kleven
openaire   +1 more source

Chicken hnRNPK suppresses interferon production, thereby enhancing IBDV replication

Research in Veterinary Science
Heterogeneous ribonucleoprotein K (hnRNPK) is a well-known RNA-binding protein initially identified for its role in inhibiting the growth of various human tumors. Members of the hnRNP family have also been implicated in both interferon production and RNA virus replication.
Ke, Wang, Ying, Hu, Jiangjiang, Nie, Qinghua, Zeng, Yu, Hu, Huansheng, Wu   +5 more
openaire   +2 more sources

Molecular characterisation of IBDV isolates in Turkey revealed reassortant strains

British Poultry Science
1. Infectious bursal disease (IBD) is an acute, highly contagious viral disease of chickens caused by a virus (IBDV) which has a bi-segmented, double-stranded RNA genome. It has five viral proteins in its structure; the VP1 gene is encoded in segment B and the other four are in segment A.2.
G. A. Kurtbeyoğlu, M. Akan
openaire   +2 more sources

Infectious bursal disease virus (IBDV) induces apoptosis in chicken B cells

Comparative Immunology, Microbiology and Infectious Diseases, 2005
The ability of infectious bursal disease virus (IBDV) serotypes 1 and 2, and the role of VP4 of both serotypes as well as the capacity of three IBDV intermediate serotype 1-specific vaccine strains to induce apoptosis in a chicken B-lymphocyte cell line, DT40, were investigated using the TUNEL technique.
Juan Carlos, Rodríguez-Lecompte, Rodolfo, Niño-Fong, Alfonso, Lopez, R J, Frederick Markham, Frederick S B, Kibenge   +4 more
openaire   +2 more sources

SRPK1 facilitates IBDV replication by phosphorylating VP1 at S48

International Journal of Biological Macromolecules
Infectious Bursal Disease Virus (IBDV), a double-stranded RNA virus of the Avibirnavirus genus, causes significant vaccine failures in immunocompromised young poultry. The VP1 protein of IBDV undergoes post-translational modifications that are critical for viral RNA transcription, genome replication, and overall viral proliferation.
Qinghua, Zeng, Zheng, Chen, Yu, Huang, Qiuling, Fu, Zhen, Chen, Huansheng, Wu   +5 more
openaire   +2 more sources