Chicken infectious anemia virus exploits host CK2α as an essential factor for its replication via VP2 Ser182/Asp183-mediated interaction [PDF]
Journal of VirologyChicken infectious anemia virus (CIAV) induces severe immunosuppression in chickens. The nonstructural protein VP2 of CIAV is shown to play critical roles in viral assembly and viral replication.
Ziyue Ma +6 more
doaj +2 more sources
Mutational analysis of human norovirus VP2 elucidates critical molecular interactions for virus assembly [PDF]
Journal of VirologyHuman noroviruses (HuNoVs) are the leading cause of viral gastroenteritis, with ≥80% of infections caused by the GII genogroup. HuNoVs are non-enveloped, with an icosahedral capsid composed of 90 dimers of the major capsid protein VP1, which encloses a ...
Janam J. Dave +5 more
doaj +2 more sources
Dual-Copy VP2 expressed with CTA1-DD in transgenic Eimeria acervulina confers partial protection against infectious bursal disease virus [PDF]
Poultry ScienceInfectious bursal disease (IBD), caused by the infectious bursal disease virus (IBDV), remains a major threat to global poultry production. The viral capsid protein VP2 is the primary protective antigen; however, conventional vaccines frequently provide ...
Yingying Sun +8 more
doaj +2 more sources
Structure-Guided Engineering of Protein VP2 from Epizootic Hemorrhagic Disease Virus Maximizes Production and Confers Complete Protection as Subunit Vaccine [PDF]
VaccinesEpizootic hemorrhagic disease (EHD) is an important livestock disease caused by Epizootic hemorrhagic disease virus (EHDV). The recent incursion and wide distribution of EHDV in Europe have increased the need for effective vaccine candidates.
Samuel Jurado +9 more
doaj +2 more sources
Viruses, 2019 Chicken infectious bursal disease (IBD) is still incompletely controlled worldwide. Although IBD virus (IBDV) VP2 DNA vaccine was considered a safe vaccine for IBD prevention, the immunogenicity by itself remains poor, resulting in the failure of ...
Yu-Zhu Zuo, Fei Zhong
exaly +3 more sources
Construction and Immunogenicity Evaluation of a Recombinant Fowlpox Virus Expressing VP2 Gene of African Horse Sickness Virus Serotype 1 [PDF]
MicroorganismsAfrican horse sickness (AHS) is a lethal vector-borne disease caused by African horse sickness virus (AHSV) and represents a major threat to equine health and the horse industry.
Xiaohua Ma +9 more
doaj +2 more sources
Frontiers in Microbiology, 2017 Infectious bursal disease (IBD) is an acute, highly contagious and immunosuppressive avian disease caused by IBD virus (IBDV). Cell apoptosis triggered by IBDV contributes to the dysfunction of immune system in host.
Yao Qin
exaly +3 more sources
Molecular characterisation of infectious bursal disease virus (IBDV) isolated from commercial broiler chickens in Nile Delta, Egypt [PDF]
Bulgarian Journal of Veterinary Medicine, 2019 Infectious bursal disease virus (IBDV) is a highly infectious disease affecting young chickens that alters predominantly the immune system. Emergence of new variants causes severe economic losses not only in Egypt but also all over the world.
N. Alkhalefa +3 more
doaj +1 more source
Detection of a new canine parvovirus mutant in Iran [PDF]
Iranian Journal of Veterinary Medicine, 2018 BACKGROUND: Canine Parvovirus (CPV) is one of the major causes of fatal gastroenteritis in young dogs. After emergence of CPV-2, two new variants were reported and named CPV-2a and CPV-2b. In 2001 the newest variant was reported and named CPV-2c.
Gholamraza Nikbakhat +2 more
doaj +1 more source
Vaccines, 2023 Porcine parvovirus 1 (PPV1) is one of the most prevalent pathogens that can cause reproductive disorder in sows. The VP2 protein of PPV1 is the most important immunogenic protein that induces neutralizing antibodies and protective immunity.
Zhanye Ling +4 more
doaj +1 more source